PLEKHG7 - pleckstrin homology and RhoGEF domain containing G7 Gene

Also Known as C12orf74

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 440107

Summary

Predicted to enable guanyl-nucleotide exchange factor activity. [provided by Alliance of Genome Resources, Jun 2026]
Biased expression in urinary bladder (RPKM 1.1), lymph node (RPKM 0.8) and 12 other tissues.

PLEKHG7 Products (3)

mRNA Protein Name
NM_001037671.4 NP_001032760.1 pleckstrin homology domain-containing family G member 7 isoform 2
NM_001178097.3 NP_001171568.1 pleckstrin homology domain-containing family G member 7 isoform 1
NM_001377329.1 NP_001364258.1 pleckstrin homology domain-containing family G member 7 isoform 3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLEKHG7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PLEKHG7 Q6ZR37 NF2 Homo sapiens P35240
Validated Y2H
32814053
Intra
PLEKHG7 Q6ZR37 NF2 Homo sapiens P35240
Y2H Array
32814053
Intra
PLEKHG7 Q6ZR37 NF2 Homo sapiens P35240
Y2H Pooling
32814053
Intra
PLEKHG7 Q6ZR37 RAB7A Homo sapiens P51149
Y2H Pooling
32814053
Intra
PLEKHG7 Q6ZR37 RAB7A Homo sapiens P51149
Validated Y2H
32814053
Intra
PLEKHG7 Q6ZR37 RAB7A Homo sapiens P51149
Y2H Array
32814053
Intra
PLEKHG7 Q6ZR37 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra
PLEKHG7 Q6ZR37 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra
PLEKHG7 Q6ZR37 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra
PLEKHG7 Q6ZR37 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
Intra
PLEKHG7 Q6ZR37 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
Intra
PLEKHG7 Q6ZR37 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
Intra
PLEKHG7 Q6ZR37 PPT1 Homo sapiens P50897
Y2H Pooling
32814053
Intra
PLEKHG7 Q6ZR37 PPT1 Homo sapiens P50897
Y2H Array
32814053
Intra
PLEKHG7 Q6ZR37 PPT1 Homo sapiens P50897
Validated Y2H
32814053
Intra
PLEKHG7 Q6ZR37 APBB2 Homo sapiens Q92870-2
Validated Y2H
32814053
Intra
PLEKHG7 Q6ZR37 APBB2 Homo sapiens Q92870-2
Y2H Pooling
32814053
Intra
PLEKHG7 Q6ZR37 APBB2 Homo sapiens Q92870-2
Y2H Array
32814053
Intra
PLEKHG7 Q6ZR37 q9y649_human Homo sapiens Q9Y649
Y2H Pooling
32814053
Intra
PLEKHG7 Q6ZR37 q9y649_human Homo sapiens Q9Y649
Validated Y2H
32814053
Intra
PLEKHG7 Q6ZR37 q9y649_human Homo sapiens Q9Y649
Y2H Array
32814053
Intra
PLEKHG7 Q6ZR37 SPTLC1 Homo sapiens O15269-2
Y2H Array
32814053
Intra
PLEKHG7 Q6ZR37 SPTLC1 Homo sapiens O15269-2
Validated Y2H
32814053
Intra
PLEKHG7 Q6ZR37 SPTLC1 Homo sapiens O15269-2
Y2H Pooling
32814053
Intra
PLEKHG7 Q6ZR37 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
PLEKHG7 Q6ZR37 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
PLEKHG7 Q6ZR37 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
PLEKHG7 Q6ZR37 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra
PLEKHG7 Q6ZR37 GSN Homo sapiens P06396
Y2H Array
32814053
Intra
PLEKHG7 Q6ZR37 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra
PLEKHG7 Q6ZR37 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
Intra
PLEKHG7 Q6ZR37 HSPB1 Homo sapiens P04792
Y2H Array
32814053
Intra
PLEKHG7 Q6ZR37 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
Intra
PLEKHG7 Q6ZR37 CCT5 Homo sapiens P48643
Validated Y2H
32814053
Intra
PLEKHG7 Q6ZR37 CCT5 Homo sapiens P48643
Y2H Array
32814053
Intra
PLEKHG7 Q6ZR37 CCT5 Homo sapiens P48643
Y2H Pooling
32814053
Intra
PLEKHG7 Q6ZR37 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
Intra
PLEKHG7 Q6ZR37 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
Intra
PLEKHG7 Q6ZR37 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
Intra
PLEKHG7 Q6ZR37 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
Intra
PLEKHG7 Q6ZR37 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
Intra
PLEKHG7 Q6ZR37 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
PLEKHG7 Q6ZR37 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
PLEKHG7 Q6ZR37 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
PLEKHG7 Q6ZR37 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
PLEKHG7 Q6ZR37 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
PLEKHG7 Q6ZR37 WFS1 Homo sapiens O76024
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10684 PLEKHA7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10689 PLEKHG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10690 PLEKHG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10691 PLEKHG3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10692 PLEKHG4B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10693 PLEKHG5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10694 PLEKHG6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22017 Plekhg3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28535 Plekhg3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown