NRARP - NOTCH regulated ankyrin repeat protein Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 441478

About NRARP

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:137,299,631-137,302,271 (from NCBI)

This gene has 1 transcript (splice variant), 187 orthologues and 2 paralogues.

Summary

Involved in Notch signaling pathway. Acts upstream of or within negative regulation of Notch signaling pathway and positive regulation of canonical Wnt signaling pathway. [provided by Alliance of Genome Resources, Apr 2022]

NRARP Products (1)

mRNA Protein Name
NM_001004354.3 NP_001004354.1 notch-regulated ankyrin repeat-containing protein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in Notch signaling pathway IDA
IDA: Inferred from direct assay
25985737 GOA
acts upstream of or within negative regulation of Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
19154719 GOA
acts upstream of or within positive regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
19154719 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NRARP Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (20 - 106)

  • 0
  • 100
  • 114 a.a.
Protein Preferred Names Protein Names

notch-regulated ankyrin repeat-containing protein

NRARP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NRARP Q7Z6K4 GTF2E1 Homo sapiens P29083
Y2H Prey Pooling
32296183
Intra
NRARP Q7Z6K4 GTF2E1 Homo sapiens P29083
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spondylocostal Dysostosis

  • Jarcho-Levin Syndrome

  • Costovertebral Dysplasia

  • Spondylothoracic Dysostosis

  • Spondylothoracic Dysplasia

  • Scdo

  • Dysostosis, Spondylocostal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09557 NRARP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21004 Nrarp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27521 Nrarp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NRARP VGNC VGNC:32252
Macaca mulatta NRARP VGNC VGNC:75498
Felis catus NRARP VGNC VGNC:102957
Rattus norvegicus NRARP RGD RGD:1591939
Mus musculus NRARP MGD MGI:1914372
Canis familiaris NRARP VGNC VGNC:43958
Others NRARP NCBI