NAP1L4 - nucleosome assembly protein 1 like 4 Gene

Also Known as NAP2; NAP2L; hNAP2; NAP1L4b

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4676

About NAP1L4

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:2,944,437-2,992,329 (from NCBI)

This gene has 23 transcripts (splice variants), 1 gene allele, 159 orthologues and 18 paralogues. Ubiquitous expression in testis (RPKM 52.4), heart (RPKM 37.7) and 25 other tissues.

Summary

This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast Cancer. [provided by RefSeq, Jul 2008]

NAP1L4 Products (14)

mRNA Protein Name
NM_001369375.1 NP_001356304.1 nucleosome assembly protein 1-like 4 isoform 1
NM_001369376.1 NP_001356305.1 nucleosome assembly protein 1-like 4 isoform 1
NM_001369377.1 NP_001356306.1 nucleosome assembly protein 1-like 4 isoform 1
NM_001369378.1 NP_001356307.1 nucleosome assembly protein 1-like 4 isoform 1
NM_001369379.1 NP_001356308.1 nucleosome assembly protein 1-like 4 isoform 1
NM_001369380.1 NP_001356309.1 nucleosome assembly protein 1-like 4 isoform 2
NM_001369381.1 NP_001356310.1 nucleosome assembly protein 1-like 4 isoform 2
NM_001369382.1 NP_001356311.1 nucleosome assembly protein 1-like 4 isoform 2
NM_001369383.1 NP_001356312.1 nucleosome assembly protein 1-like 4 isoform 2
NM_001369384.1 NP_001356313.1 nucleosome assembly protein 1-like 4 isoform 2
NM_001369385.1 NP_001356314.1 nucleosome assembly protein 1-like 4 isoform 2
NM_001369386.1 NP_001356315.1 nucleosome assembly protein 1-like 4 isoform 2
NM_001369388.1 NP_001356317.1 nucleosome assembly protein 1-like 4 isoform 2
NM_005969.4 NP_005960.1 nucleosome assembly protein 1-like 4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nucleosome binding IDA
IDA: Inferred from direct assay
9325046 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22190034 GOA
Biological Process GO Annotation Evidence References Source
involved in nucleosome assembly IDA
IDA: Inferred from direct assay
9325046 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
9325046 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9325046 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAP1L4 Protein Structure

NAP

NAP: Nucleosome assembly protein (NAP) (64 - 339)

  • 0
  • 100
  • 200
  • 300
  • 375 a.a.
Protein Preferred Names Protein Names

nucleosome assembly protein 1-like 4

  • NAP-2

NAP1L4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NAP1L4 Q99733 NAP1L1 Homo sapiens P55209
TAP
24981860
Cross
NAP1L4 Q99733 tat Human immunodeficiency virus P04608
Pull Down
22190034
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Beckwith-Wiedemann Syndrome

  • Wiedemann-Beckwith Syndrome

  • BWS

  • Exomphalos-Macroglossia-Gigantism Syndrome

  • Emg Syndrome

  • Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation

  • Emg Abnormality

  • Wbs

  • Exomphalos Macroglossia Gigantism Syndrome

  • Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation

  • Macroglossia Exomphalos Gigantism
Chikungunya

  • Chikungunya Fever

  • Arbovirus A Chikungunya Type

  • Chik

  • Chikv Infection

  • Ck

  • Chikungunya Virus Infection

  • Chikungunya Haemorrhagic Fever

  • Chikungunya Viral Disease

  • Chikungunya Mosquito-Borne Viral Fever
Wilms Tumor 5

  • Wilms Tumor

  • WT5

  • Wilms Tumor Susceptibility-5

  • Wilms Tumor And Radial Bilateral Aplasia

  • Nephroblastoma

  • Wilms' Tumor

  • Wilms Tumor, Susceptibility To

  • Wtsl

  • Bilateral Radial Aplasia With Wilms Tumor

  • Embryonal Adenosarcoma

  • Embryonal Nephroma

  • Kidney Wilms Tumor

  • Kidney, Adenomyosarcoma, Embryonal

  • Kidney, Carcinosarcoma, Embryonal

  • Kidney, Embryoma

  • Kidney, Embryonal Mixed Tumor

  • Nephroma

  • Renal Adenosarcoma

  • Renal Cancer, Wilms

  • Renal Wilms Tumor

  • Tumor, Wilms

  • Hereditary Susceptibility To Wilms Tumor 5
Familial Apolipoprotein C-Ii Deficiency

  • Familial Apoc-Ii Deficiency

  • Familial Apoc2 Deficiency

  • C-Ii Anapolipoproteinemia

  • Hyperlipoproteinemia, Type 1b

  • Hyperlipoproteinemia, Type Ib

  • Hyperlipoproteinemia Type I
Polyhydramnios
Cockayne Syndrome A

  • Cockayne Syndrome Type 1

  • Cockayne Syndrome, Type A

  • Cockayne Syndrome Type I

  • CSA

  • Cockayne Syndrome Classic Form

  • Cockayne Syndrome Classical

  • Cockayne Syndrome Type A

  • Ckn1
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09028 NAP1L4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta NAP1L4 VGNC VGNC:101365
Rattus norvegicus NAP1L4 RGD RGD:1305391
Felis catus NAP1L4 VGNC VGNC:68413
Bos taurus NAP1L4 VGNC VGNC:31879
Mus musculus NAP1L4 MGD MGI:1316687
Canis familiaris NAP1L4 VGNC VGNC:43617
Others NAP1L4 NCBI