1. Gene
  2. NAP1L4 - nucleosome assembly protein 1 like 4 Gene

NAP1L4 - nucleosome assembly protein 1 like 4 Gene

Homo sapiens

Also known as NAP2; NAP2L; hNAP2; NAP1L4b

Gene ID: 4676 | Gene type: protein coding

About NAP1L4

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:2,944,437-2,992,329 (from NCBI)

This gene has 23 transcripts (splice variants), 1 gene allele, 159 orthologues and 18 paralogues. Ubiquitous expression in testis (RPKM 52.4), heart (RPKM 37.7) and 25 other tissues.

Summary

This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast Cancer. [provided by RefSeq, Jul 2008]

NAP1L4 Products(14)

mRNA Protein Name
NM_001369375.1 NP_001356304.1 nucleosome assembly protein 1-like 4 isoform 1
NM_001369376.1 NP_001356305.1 nucleosome assembly protein 1-like 4 isoform 1
NM_001369377.1 NP_001356306.1 nucleosome assembly protein 1-like 4 isoform 1
NM_001369378.1 NP_001356307.1 nucleosome assembly protein 1-like 4 isoform 1
NM_001369379.1 NP_001356308.1 nucleosome assembly protein 1-like 4 isoform 1
NM_001369380.1 NP_001356309.1 nucleosome assembly protein 1-like 4 isoform 2
NM_001369381.1 NP_001356310.1 nucleosome assembly protein 1-like 4 isoform 2
NM_001369382.1 NP_001356311.1 nucleosome assembly protein 1-like 4 isoform 2
NM_001369383.1 NP_001356312.1 nucleosome assembly protein 1-like 4 isoform 2
NM_001369384.1 NP_001356313.1 nucleosome assembly protein 1-like 4 isoform 2
NM_001369385.1 NP_001356314.1 nucleosome assembly protein 1-like 4 isoform 2
NM_001369386.1 NP_001356315.1 nucleosome assembly protein 1-like 4 isoform 2
NM_001369388.1 NP_001356317.1 nucleosome assembly protein 1-like 4 isoform 2
NM_005969.4 NP_005960.1 nucleosome assembly protein 1-like 4 isoform 1

NAP1L4 Protein Structure

NAP

NAP: Nucleosome assembly protein (NAP) (64 - 339)

  • 0
  • 100
  • 200
  • 300
  • 375 a.a.
Protein Preferred Names Protein Names

nucleosome assembly protein 1-like 4

NAP-2

Related Diseases

Diseases Alias
Beckwith-Wiedemann Syndrome

Wiedemann-Beckwith Syndrome

BWS

Exomphalos-Macroglossia-Gigantism Syndrome

Emg Syndrome

Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation

Emg Abnormality

Wbs

Exomphalos Macroglossia Gigantism Syndrome

Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation

Macroglossia Exomphalos Gigantism

Chikungunya

Chikungunya Fever

Arbovirus A Chikungunya Type

Chik

Chikv Infection

Ck

Chikungunya Virus Infection

Chikungunya Haemorrhagic Fever

Chikungunya Viral Disease

Chikungunya Mosquito-Borne Viral Fever

Wilms Tumor 5

Wilms Tumor

WT5

Wilms Tumor Susceptibility-5

Wilms Tumor And Radial Bilateral Aplasia

Nephroblastoma

Wilms' Tumor

Wilms Tumor, Susceptibility To

Wtsl

Bilateral Radial Aplasia With Wilms Tumor

Embryonal Adenosarcoma

Embryonal Nephroma

Kidney Wilms Tumor

Kidney, Adenomyosarcoma, Embryonal

Kidney, Carcinosarcoma, Embryonal

Kidney, Embryoma

Kidney, Embryonal Mixed Tumor

Nephroma

Renal Adenosarcoma

Renal Cancer, Wilms

Renal Wilms Tumor

Tumor, Wilms

Hereditary Susceptibility To Wilms Tumor 5

Familial Apolipoprotein C-Ii Deficiency

Familial Apoc-Ii Deficiency

Familial Apoc2 Deficiency

C-Ii Anapolipoproteinemia

Hyperlipoproteinemia, Type 1b

Hyperlipoproteinemia, Type Ib

Hyperlipoproteinemia Type I

Polyhydramnios
Cockayne Syndrome A

Cockayne Syndrome Type 1

Cockayne Syndrome, Type A

Cockayne Syndrome Type I

CSA

Cockayne Syndrome Classic Form

Cockayne Syndrome Classical

Cockayne Syndrome Type A

Ckn1

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta NAP1L4 VGNC VGNC:101365
Rattus norvegicus NAP1L4 RGD RGD:1305391
Felis catus NAP1L4 VGNC VGNC:68413
Bos taurus NAP1L4 VGNC VGNC:31879
Mus musculus NAP1L4 MGD MGI:1316687
Canis familiaris NAP1L4 VGNC VGNC:43617