NDUFB5 - NADH:ubiquinone oxidoreductase subunit B5 Gene

Also Known as SGDH; CISGDH

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4711

About NDUFB5

Cytogenetic location: 3q26.33 Genomic coordinates (GRCh38): 3:179,604,794-179,627,647 (from NCBI)

This gene has 16 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in heart (RPKM 79.6), fat (RPKM 69.6) and 25 other tissues.

Summary

The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

NDUFB5 Products (3)

mRNA Protein Name
NM_001199957.2 NP_001186886.1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform 2
NM_001199958.2 NP_001186887.1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform 3 precursor
NM_002492.4 NP_002483.1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in mitochondrial respiratory chain complex I assembly IMP
IMP: Inferred from mutant phenotype
27626371 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
28844695 GOA
part of respiratory chain complex I IDA
IDA: Inferred from direct assay
12611891 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NDUFB5 Protein Structure

NDUF_B5

NDUF_B5: NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit (1 - 189)

  • 0
  • 100
  • 189 a.a.
Protein Preferred Names Protein Names

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

  • NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa

NDUFB5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NDUFB5 O43674 SCAND1 Homo sapiens P57086
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09150 NDUFB5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NDUFB5 VGNC VGNC:31964
Rattus norvegicus NDUFB5 RGD RGD:1305909
Macaca mulatta NDUFB5 VGNC VGNC:75158
Felis catus NDUFB5 VGNC VGNC:68441
Mus musculus NDUFB5 MGD MGI:1913296
Others NDUFB5 NCBI