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NDUFS5 - NADH:ubiquinone oxidoreductase subunit S5 Gene

Also Known as CI15K; CI-15k

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4725

About NDUFS5

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:39,026,350-39,034,615 (from NCBI)

This gene has 2 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in heart (RPKM 174.0), fat (RPKM 138.7) and 25 other tissues.

Summary

This gene is a member of the NADH dehydrogenase (ubiquinone) iron-sulfur protein family. The encoded protein is a subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 1, 4 and 17. [provided by RefSeq, May 2010]

NDUFS5 Products (2)

mRNA	Protein	Name
NM_001184979.2	NP_001171908.1	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
NM_004552.3	NP_004543.1	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17500595	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mitochondrial respiratory chain complex I assembly	IMP IMP: Inferred from mutant phenotype	11112787	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	28844695	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	16826196	GOA
part of respiratory chain complex I	IDA IDA: Inferred from direct assay	12611891	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NDUFS5 Protein Structure

Ndufs5

0
100
106 a.a.

Protein Preferred Names	Protein Names
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	CI-15 kDa

NDUFS5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NDUFS5	O43920	SGSM1	Homo sapiens	Q2NKQ1-4	Validated Y2H	32814053
Intra	NDUFS5	O43920	SGSM1	Homo sapiens	Q2NKQ1-4	Y2H Array	32814053
Intra	NDUFS5	O43920	SGSM1	Homo sapiens	Q2NKQ1-4	Y2H Pooling	32814053
Intra	NDUFS5	O43920	ARFGAP3	Homo sapiens	Q9NP61	Y2H Array	32814053
Intra	NDUFS5	O43920	ARFGAP3	Homo sapiens	Q9NP61	Y2H Pooling	32814053
Intra	NDUFS5	O43920	ARFGAP3	Homo sapiens	Q9NP61	Validated Y2H	32814053
Intra	NDUFS5	O43920	SPATS1	Homo sapiens	Q496A3	Validated Y2H	32814053
Intra	NDUFS5	O43920	SPATS1	Homo sapiens	Q496A3	Y2H Pooling	32814053
Intra	NDUFS5	O43920	SPATS1	Homo sapiens	Q496A3	Y2H Array	32814053
Intra	NDUFS5	O43920	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	NDUFS5	O43920	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	NDUFS5	O43920	HTT	Homo sapiens	P42858	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Mitochondrial Dna Depletion Syndrome 9	MTDPS9 Fatal Infantile Lactic Acidosis Lactic Acidosis, Fatal Infantile, Formerly Fatal Infantile Lactic Acidosis With Methylmalonic Aciduria Mitochondrial Dna Depletion Syndrome 9 Encephalomyopathic Type With Methylmalonic Aciduria Mitochondrial Dna Depletion Syndrome, Type 9 Lactic Acidosis, Fatal Infantile
Mitochondrial Complex I Deficiency, Nuclear Type 1	Mitochondrial Complex I Deficiency Nadh:Q(1) Oxidoreductase Deficiency MC1DN1 Nadh-Coenzyme Q Reductase Deficiency Isolated Mitochondrial Respiratory Chain Complex I Deficiency Isolated Nadh-Coenzyme Q Reductase Deficiency Isolated Nadh-Coq Reductase Deficiency Isolated Nadh-Ubiquinone Reductase Deficiency Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of Nuclear Type Mitochondrial Complex I Deficiency 1 Isolated Complex I Deficiency Complex 1 Mitochondrial Respiratory Chain Deficiency Nadh Coenzyme Q Reductase Deficiency Complex I Mitochondrial Respiratory Chain Deficiency Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I Nadh:Ubiquinone Oxidoreductase Deficiency Complex I, Mitochondrial Respiratory Chain, Deficiency Of

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09161	NDUFS5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21163	Ndufs5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27679	Ndufs5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NDUFS5	RGD	RGD:1311081
Mus musculus	NDUFS5	MGD	MGI:1890889
Canis familiaris	NDUFS5	VGNC	VGNC:108230
Bos taurus	NDUFS5	VGNC	VGNC:31970
Felis catus	NDUFS5	VGNC	VGNC:68446
Others	NDUFS5	NCBI