SMO - smoothened, frizzled class receptor Gene

Species: Canis lupus familiaris (sub-species: familiaris)

Gene Type: protein coding
Gene ID: 482262

About SMO

Primary_assembly 14: 7,284,738-7,307,899 reverse strand.ROS_Cfam_1.0:CM025113.1

This gene has 1 transcript (splice variant), 203 orthologues and 15 paralogues.

SMO Products (2)

mRNA Protein Name
XM_038686174.1 XP_038542102.1 smoothened homolog isoform X1
XM_038686175.1 XP_038542103.1 smoothened homolog isoform X2

SMO Protein Structure

CRD_SMO

CRD_SMO: cd07451 (64 - 194)

7tmF_SMO_homolog

7tmF_SMO_homolog: cd15030 (218 - 548)

7tmF_SMO_homolog

7tmF_SMO_homolog: cd15030 (227 - 252)

7tmF_SMO_homolog

7tmF_SMO_homolog: cd15030 (262 - 283)

7tmF_SMO_homolog

7tmF_SMO_homolog: cd15030 (313 - 339)

7tmF_SMO_homolog

7tmF_SMO_homolog: cd15030 (357 - 373)

7tmF_SMO_homolog

7tmF_SMO_homolog: cd15030 (395 - 424)

7tmF_SMO_homolog

7tmF_SMO_homolog: cd15030 (446 - 473)

7tmF_SMO_homolog

7tmF_SMO_homolog: cd15030 (509 - 534)

  • 0
  • 200
  • 400
  • 600
  • 788 a.a.
Protein Preferred Names Protein Names

smoothened homolog

  • smoothened, frizzled family receptor

  • smoothened, seven transmembrane spanning receptor

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16582A Sonidegib Antagonist 99.98% Yes
HY-16391 Glasdegib Inhibitor 99.65% Yes
HY-B0603 Fluticasone Agonist 98.70% Yes
HY-16582 Sonidegib diphosphate Antagonist 99.97% Yes
HY-B0877 Halcinonide Agonist 98.29% Unkown
HY-16391A Glasdegib maleate Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-13654 IPI-269609 Inhibitor / Phase 4
HY-16587 Saridegib Inhibitor 99.95% Phase 3
HY-13809 BMS-833923 Inhibitor 99.82% Phase 2
HY-13242 Taladegib Inhibitor 99.92% Phase 2
HY-18636 LEQ506 Inhibitor 98.92% Phase 1

Pre-clinical Phase

Bioactive Molecules (56)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12848 SAG Agonist 99.79% Unkown
HY-17024 Cyclopamine Inhibitor 99.97% Unkown
HY-15108 Purmorphamine Activator 99.94% Unkown
HY-100224 SANT-1 Antagonist 99.87% Unkown
HY-12848B SAG hydrochloride Agonist 99.91% Unkown
HY-12848C SAG dihydrochloride Agonist 98.23% Unkown
HY-15483 DY131 Inhibitor 99.72% Unkown
HY-100535 KAAD-Cyclopamine Antagonist ≥96.0% Unkown
HY-12316 20(S)-Hydroxycholesterol Activator 99.63% Unkown
HY-15108G Purmorphamine (GMP) Agonist / Unkown
HY-N0836 Jervine Inhibitor 99.28% Unkown
HY-12317 GSA-10 Agonist ≥98.0% Unkown
HY-13459 PF-5274857 Antagonist 99.31% Unkown
HY-15412 HhAntag 99.40% Unkown
HY-N0247 Saikosaponin B1 Inhibitor 99.42% Unkown
HY-151115 JNJ-1289 Inhibitor 98.06% Unkown
HY-12848R SAG (Standard) Agonist 99.56% Unkown
HY-137115 BODIPY-Cyclopamine 98.91% Unkown
HY-113965 CUR61414 Inhibitor 99.04% Unkown
HY-115566 S1PL-IN-1 Antagonist 99.9% Unkown
HY-100036 MK-4101 Antagonist 99.16% Unkown
HY-117407 ALLO-2 Antagonist 99.72% Unkown
HY-18287 MRT-83 Antagonist 99.27% Unkown
HY-18287A MRT-83 hydrochloride Antagonist 99.60% Unkown
HY-100224G SANT-1 (GMP) Antagonist / Unkown
HY-120499 AZD8542 Antagonist 99.49% Unkown
HY-110240 IHR-1 Antagonist 98.05% Unkown
HY-145387 MRT-81 Antagonist 99.85% Unkown
HY-108507 MRT-10 Antagonist 98.99% Unkown
HY-108508 SMANT hydrochloride Inhibitor 99.90% Unkown
HY-12316R 20(S)-Hydroxycholesterol (Standard) Activator 98.69% Unkown
HY-13459A PF-5274857 hydrochloride Antagonist / Unkown
HY-147744 AZD7254 Inhibitor / Unkown
HY-150567 SMO-IN-3 Inhibitor / Unkown
HY-12848S SAG-d3 Inhibitor 99.85% Unkown
HY-177291 LAB687 Antagonist / Unkown
HY-16391S1 Glasdegib-d4 Inhibitor / Unkown
HY-183335 SMO-IN-6 Inhibitor / Unkown
HY-148440 RL-0070933 Modulator / Unkown
HY-162273 Antibacterial agent 189 / Unkown
HY-162372 Hedgehog IN-6 Inhibitor / Unkown
HY-12848A (Rac)-SAG Agonist / Unkown
HY-16391B Glasdegib hydrochloride Inhibitor / Unkown
HY-159893 SMO-IN-5 Inhibitor / Unkown
HY-147743 SMO-IN-1 Inhibitor / Unkown
HY-131016 IHR-Cy3 Antagonist / Unkown
HY-110326 Smo antagonist M25 Antagonist / Unkown
HY-147670 TPB15 Inhibitor / Unkown
HY-153499 SMO-IN-4 Antagonist / Unkown
HY-145918 MRT-14 Antagonist 98.91% Unkown
HY-16587A Saridegib hydrochloride Inhibitor / Unkown
HY-123752 MS-0022 Antagonist / Unkown
HY-150564 SMO-IN-2 Inhibitor 98.12% Unkown
HY-117903A MRT-92 Antagonist / Unkown
HY-133974 7-keto-25-Hydroxycholesterol Activator / Unkown
HY-12848G SAG (GMP) Agonist / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990418 Anti-FZD7 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens SMO NCBI NCBI:6608