EID3 - EP300 interacting inhibitor of differentiation 3 Gene

Also Known as NS4EB; NSE4B; NSMCE4B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 493861

About EID3

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:104,303,739-104,305,205 (from NCBI)

This gene has 1 transcript (splice variant), 101 orthologues and 1 paralogue.

Summary

Predicted to be involved in DNA repair. Located in nucleolus and nucleoplasm. Part of Smc5-Smc6 complex. [provided by Alliance of Genome Resources, Apr 2022]

EID3 Products (1)

mRNA Protein Name
NM_001008394.3 NP_001008395.1 EP300-interacting inhibitor of differentiation 3

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21364888 GOA
Cellular Component GO Annotation Evidence References Source
part of Smc5-Smc6 complex IDA
IDA: Inferred from direct assay
18086888 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EID3 Protein Structure

Nse4-Nse3_bdg

Nse4-Nse3_bdg: Binding domain of Nse4/EID3 to Nse3-MAGE (89 - 140)

Nse4_C

Nse4_C: Nse4 C-terminal (239 - 330)

  • 0
  • 100
  • 200
  • 300
  • 333 a.a.
Protein Preferred Names Protein Names

EP300-interacting inhibitor of differentiation 3

  • E1A-like inhibitor of differentiation 3

EID3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EID3 Q8N140 NSMCE3 Homo sapiens Q96MG7
Anti Tag CoIP
33961781
Intra
EID3 Q8N140 NSMCE3 Homo sapiens Q96MG7
Anti Tag CoIP
28514442
Intra
EID3 Q8N140 NSMCE3 Homo sapiens Q96MG7
TEM
32389690
Intra
EID3 Q8N140 NSMCE3 Homo sapiens Q96MG7
Crosslink
32389690
Intra
EID3 Q8N140 NSMCE3 Homo sapiens Q96MG7
Anti Tag CoIP
21364888
Intra
EID3 Q8N140 SMC5 Homo sapiens Q8IY18
Y2H
32389690
Intra
EID3 Q8N140 SMC5 Homo sapiens Q8IY18
Crosslink
32389690
Intra
EID3 Q8N140 SMC5 Homo sapiens Q8IY18
Anti Tag CoIP
33961781
Intra
EID3 Q8N140 SMC5 Homo sapiens Q8IY18
Anti Tag CoIP
28514442
Intra
EID3 Q8N140 SMC5 Homo sapiens Q8IY18
TEM
32389690
Intra
EID3 Q8N140 MAGEA1 Homo sapiens P43355
Anti Tag CoIP
21364888
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Floating-Harbor Syndrome

  • FLHS

  • Fhs

  • Pelletier-Leisti Syndrome

  • Short Stature With Delayed Bone Age, Expressive Language Delay, A Triangular Face With A Prominent Nose And Deep-Set Eyes

  • Leisti-Hollander-Rimoin Syndrome
Sotos Syndrome 2

  • Sotos2

  • Sotos Syndrome, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04236 EID3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus EID3 RGD RGD:1597206
Mus musculus EID3 MGD MGI:1913591
Others EID3 NCBI