ATP4B - ATPase H+/K+ transporting subunit beta Gene

Also Known as ATP6B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 496

About ATP4B

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:113,648,804-113,658,198 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 171 orthologues and 4 paralogues. Restricted expression toward stomach (RPKM 286.6).

Summary

The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a Proton Pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes the beta subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008]

ATP4B Products (1)

mRNA	Protein	Name
NM_000705.4	NP_000696.1	potassium-transporting ATPase subunit beta

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATP4B Protein Structure

Na_K-ATPase

0
100
200
291 a.a.

Protein Preferred Names	Protein Names
potassium-transporting ATPase subunit beta	ATPase H+/K+ transporting beta subunit

ATP4B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ATP4B	P51164	GPR42	Homo sapiens	O15529	Y2H Prey Pooling	32296183
Intra	ATP4B	P51164	GPR42	Homo sapiens	O15529	Y2H Array	32296183
Intra	ATP4B	P51164	ZC4H2	Homo sapiens	Q9NQZ6	Validated Y2H	32296183
Intra	ATP4B	P51164	ZC4H2	Homo sapiens	Q9NQZ6	Y2H Array	32296183
Intra	ATP4B	P51164	ZC4H2	Homo sapiens	Q9NQZ6	Y2H Prey Pooling	32296183
Intra	ATP4B	P51164	CCNDBP1	Homo sapiens	O95273	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

ATP4B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83227	ATP4B Antibody (YA2972)	WB	Human

Related Diseases

Diseases	Alias
Chronic Laryngitis
Myasthenic Syndrome, Congenital, 11, Associated With Acetylcholine Receptor Deficiency	Congenital Myasthenic Syndrome 11 CMS11 Cms Ie Cms1e Myasthenic Syndrome, Congenital, Ie Myasthenic Syndrome, Congenital, Ie, Formerly Cms1e, Formerly Cms Ie, Formerly Congenital Myasthenic Syndrome 11 Associated With Acetylcholine Receptor Deficiency Congenital Myasthenic Syndrome 1e Myasthenic Syndrome, Congenital, Type 11, Associated With Acetylcholine Receptor Deficiency
Autoimmune Gastritis
Brain Small Vessel Disease 2	Porencephaly 2 BSVD2 Gould Syndrome 2 Porencephaly 2, Formerly Poren2, Formerly Poren2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01201	ATP4B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21097	Atp1b1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ATP4B	VGNC	VGNC:106251
Rattus norvegicus	ATP4B	RGD	RGD:2178
Bos taurus	ATP4B	VGNC	VGNC:26298
Felis catus	ATP4B	VGNC	VGNC:68642
Mus musculus	ATP4B	MGD	MGI:88114
Canis familiaris	ATP4B	VGNC	VGNC:38263
Others	ATP4B	NCBI