Acd - adrenocortical dysplasia Gene

Mus musculus

Gene ID: 497652 | Gene type: protein coding

About Acd

Summary

Enables telomeric DNA binding activity. Involved in protection from non-homologous end joining at telomere. Acts upstream of or within several processes, including embryonic limb morphogenesis; segmentation; and skeletal system development. Located in chromosome, telomeric region. Part of nuclear telomere cap complex. Is expressed in several structures, including adrenal gland; genitourinary system; liver; neural tube; and spleen. Human ortholog(s) of this gene implicated in autosomal dominant dyskeratosis congenita 6. Orthologous to human ACD (ACD shelterin complex subunit and Telomerase recruitment factor). [provided by Alliance of Genome Resources, Apr 2022]

Acd Products(2)

mRNA	Protein	Name
NM_001012638.2	NP_001012656.1	adrenocortical dysplasia protein isoform 1
NM_001348349.1	NP_001335278.1	adrenocortical dysplasia protein isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17053789	MGI
enables telomeric DNA binding	IDA IDA: Inferred from direct assay	23685356	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within embryonic limb morphogenesis	IMP IMP: Inferred from mutant phenotype	15537664	MGI
involved in protection from non-homologous end joining at telomere	IMP IMP: Inferred from mutant phenotype	18185984	MGI
acts upstream of or within segmentation	IMP IMP: Inferred from mutant phenotype	15537664	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	15537664	MGI
involved in telomere capping	IMP IMP: Inferred from mutant phenotype	17632522	MGI
acts upstream of or within urogenital system development	IMP IMP: Inferred from mutant phenotype	15537664	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	23685356	MGI
part of nuclear telomere cap complex	IDA IDA: Inferred from direct assay	18185984	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

adrenocortical dysplasia protein

Acd Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Acd	Q5EE38	Stn1	Mus musculus	Q8K2X3	Anti Bait CoIP	19648609

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0579	Cyclosporin A	Inhibitor	99.90%	Yes

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10063	Ispronicline	Agonist	98.24%	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0579S	Cyclosporin A-d4		99.20%	Unkown
HY-B0579S2	Cyclosporin A acetate-d4	Inhibitor	99.90%	Unkown
HY-B0579S3	Cyclosporin A-13C2,d4		95.21%	Unkown
HY-114680	ACD-10284		/	Unkown
HY-RS00148	ACD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W044285	Fmoc-D-4-Aph(cBm)-OH		/	Unkown
HY-W101384	Ac-D-2-Nal-OH		/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990258	Anti-Mouse CLEC9A/CD370 Antibody (7H11)		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Acd	NCBI	NCBI:65057
Macaca fascicularis	Acd	NCBI	NCBI:102147132
Rattus norvegicus	Acd	NCBI	NCBI:307798

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