Acd - adrenocortical dysplasia Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 497652

Summary

Enables telomeric DNA binding activity. Involved in protection from non-homologous end joining at telomere. Acts upstream of or within several processes, including embryonic limb morphogenesis; segmentation; and skeletal system development. Located in chromosome, telomeric region. Part of nuclear telomere cap complex. Is expressed in several structures, including adrenal gland; genitourinary system; liver; neural tube; and spleen. Human ortholog(s) of this gene implicated in autosomal dominant dyskeratosis congenita 6. Orthologous to human ACD (ACD shelterin complex subunit and Telomerase recruitment factor). [provided by Alliance of Genome Resources, Apr 2022]

Acd Products (2)

mRNA Protein Name
NM_001012638.2 NP_001012656.1 adrenocortical dysplasia protein isoform 1
NM_001348349.1 NP_001335278.1 adrenocortical dysplasia protein isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17053789 MGI
enables telomeric DNA binding IDA
IDA: Inferred from direct assay
23685356 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within embryonic limb morphogenesis IMP
IMP: Inferred from mutant phenotype
15537664 MGI
involved in protection from non-homologous end joining at telomere IMP
IMP: Inferred from mutant phenotype
18185984 MGI
acts upstream of or within segmentation IMP
IMP: Inferred from mutant phenotype
15537664 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
15537664 MGI
involved in telomere capping IMP
IMP: Inferred from mutant phenotype
17632522 MGI
acts upstream of or within urogenital system development IMP
IMP: Inferred from mutant phenotype
15537664 MGI
Cellular Component GO Annotation Evidence References Source
located in chromosome, telomeric region IDA
IDA: Inferred from direct assay
23685356 MGI
part of nuclear telomere cap complex IDA
IDA: Inferred from direct assay
18185984 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

adrenocortical dysplasia protein

Acd Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Acd Q5EE38 Stn1 Mus musculus Q8K2X3
Anti Bait CoIP
19648609
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0579 Cyclosporin A Inhibitor 99.94% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-10063 Ispronicline Agonist 98.24% Phase 2
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990676 VIB-9600 Inhibitor 99.41% Phase 1

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-B0579S Cyclosporin A-d4 Inhibitor 99.59% Unkown
HY-W046325 DEAE-Cellulose 0.00% Unkown
HY-B0579S2 Cyclosporin A acetate-d4 Inhibitor 99.90% Unkown
HY-B0579S3 Cyclosporin A-13C2,d4 Inhibitor 95.21% Unkown
HY-W101384 Ac-D-2-Nal-OH 99.93% Unkown
HY-B0579S5 Cyclosporin A-d12 Inhibitor / Unkown
HY-114680 ACD-10284 / Unkown
HY-124133 JNJ-42905343 Inhibitor / Unkown
HY-RS00148 ACD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W044285 Fmoc-D-4-Aph(cBm)-OH / Unkown
HY-B0579S1 Cyclosporin A-d3 Inhibitor / Unkown
HY-RS17284 Acd Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23739 Acd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990258 Anti-Mouse CLEC9A/CD370 Antibody (7H11) Inhibitor 95% Unkown
HY-P991570 Zaptuzumab 99.0% Unkown
HY-P991881 KY1070 / Unkown
HY-P991819 Anti-Mouse ICAM-1 Antibody (BE29G1) Inhibitor / Unkown
HY-P992333 CLT030 Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acd NCBI NCBI:65057