Pkd2 - polycystin 2, transient receptor potential cation channel Gene

Also Known as Trpp2; RGD1559992

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 498328

About Pkd2

Primary_assembly 14: 5,237,135-5,280,825 reverse strand.mRatBN7.2:CM026987.1

This gene has 1 transcript (splice variant), 222 orthologues, 10 paralogues and is associated with 18 phenotypes. Biased expression in Kidney (RPKM 188.3), Adrenal (RPKM 164.1) and 9 other tissues.

Summary

Enables muscle alpha-actinin binding activity. Involved in positive regulation of cytosolic calcium ion concentration. Located in endoplasmic reticulum and membrane. Biomarker of acute kidney failure. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; intracranial aneurysm; polycystic kidney disease; polycystic kidney disease 2; and retinal degeneration. Orthologous to human PKD2 (polycystin 2, transient receptor potential cation channel). [provided by Alliance of Genome Resources, Apr 2022]

Pkd2 Products (1)

mRNA Protein Name
NM_001191934.1 NP_001178863.1 polycystin-2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables alpha-actinin binding IPI
IPI: Inferred from physical interaction
15843396 RGD
enables muscle alpha-actinin binding IPI
IPI: Inferred from physical interaction
15843396 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
16952559 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pkd2 Protein Structure

PKD_channel

PKD_channel: pfam08016 (266 - 684)

Fer4_24

Fer4_24: cl39498 (831 - 865)

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  • 800
  • 966 a.a.
Protein Preferred Names Protein Names

polycystin-2

  • polycystic kidney disease 2 (autosomal dominant)

  • polycystic kidney disease 2 homolog

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-15698 CRT0066101 Inhibitor 99.88% Phase 1

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13687 IKK 16 Inhibitor 99.88% Unkown
HY-15698A CRT0066101 dihydrochloride Inhibitor 99.97% Unkown
HY-13941 1-Naphthyl PP1 Inhibitor 99.36% Unkown
HY-13687A IKK 16 hydrochloride Inhibitor 99.95% Unkown
HY-12239 CID755673 Inhibitor 99.13% Unkown
HY-118052 BPKDi Inhibitor 99.74% Unkown
HY-13454 CID 2011756 Inhibitor 96.98% Unkown
HY-15528 kb NB 142-70 Inhibitor 98.02% Unkown
HY-151374 3-IN-PP1 Inhibitor 99.37% Unkown
HY-15698B CRT0066101 trihydrochloride Inhibitor / Unkown
HY-151372 Protein kinase D inhibitor 1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pkd2 NCBI NCBI:5311