2. Gene
  3. Kdm1a - lysine demethylase 1A Gene

Kdm1a - lysine demethylase 1A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Aof2; Kdm1; RGD1562975

Gene ID: 500569 | Gene type: protein coding

About Kdm1a

Primary_assembly 5: 148,782,976-148,838,319 reverse strand.mRatBN7.2:CM026978.1

This gene has 3 transcripts (splice variants), 215 orthologues, 10 paralogues and is associated with 19 phenotypes. Biased expression in Thymus (RPKM 19.), Brain (RPKM 146.9) and 9 other tissues.

Summary

Enables chromatin binding activity. Involved in several processes, including cellular response to cAMP; nervous system development; and response to fungicide. Located in chromatin and nucleus. Biomarker of breast cancer; diabetic retinopathy; schizophrenia; and transient cerebral ischemia. Orthologous to human KDM1A (lysine demethylase 1A). [provided by Alliance of Genome Resources, Apr 2022]

Kdm1a Products(1)

mRNA Protein Name
NM_001130098.1 NP_001123570.1 lysine-specific histone demethylase 1A

Kdm1a Protein Structure

PHA03378

PHA03378: cl33729 (37 - 97)

PLN02328

PLN02328: cl33466 (202 - 848)

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  • 876 a.a.
Protein Preferred Names Protein Names

lysine-specific histone demethylase 1A

amine oxidase (flavin containing) domain 2

lysine (K)-specific demethylase 1

lysine (K)-specific demethylase 1A

neuroprotective protein 3

Related Agents

Clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-18632 GSK2879552 Inhibitor 99.75% Phase 2
HY-103713 Seclidemstat Inhibitor 99.77% Phase 2
HY-18632A GSK2879552 dihydrochloride Inhibitor 99.52% Phase 2
HY-12782T Iadademstat dihydrochloride Inhibitor 99.83% Phase 1
HY-138830 TAK-418 Inhibitor 98.64% Phase 1
Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-103713A Seclidemstat mesylate Inhibitor 99.86% Unkown
HY-19612B DDP-38003 trihydrochloride Inhibitor / Unkown
HY-19612A DDP-38003 dihydrochloride 98.22% Unkown
HY-109117 Iadademstat Inhibitor / Unkown
HY-112304 NCD38 TFA Inhibitor / Unkown
HY-112304A (1R,2S)-NCD38 TFA Inhibitor / Unkown
HY-143238 FY-56 Inhibitor / Unkown
HY-RS07205 KDM1A Human Pre-designed siRNA Set A / Unkown
HY-RS07206 Kdm1a Mouse Pre-designed siRNA Set A / Unkown
HY-RS07207 Kdm1a Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kdm1a NCBI NCBI:23028