Kdm1a - lysine demethylase 1A Gene

Also Known as Aof2; Kdm1; RGD1562975

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 500569

About Kdm1a

Primary_assembly 5: 148,782,976-148,838,319 reverse strand.mRatBN7.2:CM026978.1

This gene has 3 transcripts (splice variants), 215 orthologues, 10 paralogues and is associated with 19 phenotypes. Biased expression in Thymus (RPKM 19.), Brain (RPKM 146.9) and 9 other tissues.

Summary

Enables chromatin binding activity. Involved in several processes, including cellular response to cAMP; nervous system development; and response to fungicide. Located in chromatin and nucleus. Biomarker of breast cancer; diabetic retinopathy; schizophrenia; and transient cerebral ischemia. Orthologous to human KDM1A (lysine demethylase 1A). [provided by Alliance of Genome Resources, Apr 2022]

Kdm1a Products (1)

mRNA	Protein	Name
NM_001130098.1	NP_001123570.1	lysine-specific histone demethylase 1A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	23221071	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	24227653	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to cAMP	IEP IEP: Inferred from expression pattern	20418916	RGD
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	20164337	RGD
involved in guanine metabolic process	IMP IMP: Inferred from mutant phenotype	20418916	RGD
involved in neuron maturation	IEP IEP: Inferred from expression pattern	20164337	RGD
involved in positive regulation of cell size	IMP IMP: Inferred from mutant phenotype	20164337	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	20164337	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20418916	RGD
involved in protein modification process	IEP IEP: Inferred from expression pattern	23221071	RGD
involved in protein modification process	IMP IMP: Inferred from mutant phenotype	20418916	RGD
involved in response to fungicide	IEP IEP: Inferred from expression pattern	22496781	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	22496781	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	23221071	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Kdm1a Protein Structure

PHA03378

PLN02328

0
200
400
600
800
876 a.a.

Protein Preferred Names	Protein Names
lysine-specific histone demethylase 1A	amine oxidase (flavin containing) domain 2 lysine (K)-specific demethylase 1 lysine (K)-specific demethylase 1A neuroprotective protein 3

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Phase
HY-18632	GSK2879552	Inhibitor	99.98%	Phase 2
HY-12782T	Iadademstat dihydrochloride	Inhibitor	99.98%	Phase 2
HY-109117	Iadademstat		99.82%	Phase 2
HY-103713	Seclidemstat	Inhibitor	99.77%	Phase 2
HY-18632A	GSK2879552 dihydrochloride	Inhibitor	99.82%	Phase 2
HY-103713A	Seclidemstat mesylate	Inhibitor	99.80%	Phase 2
HY-138830	TAK-418	Inhibitor	99.81%	Phase 1

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19612A	DDP-38003 dihydrochloride	Inhibitor	99.31%	Unkown
HY-RS07205	KDM1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-19612B	DDP-38003 trihydrochloride	Inhibitor	/	Unkown
HY-183067	TAS1440		/	Unkown
HY-112304	NCD38 TFA	Inhibitor	/	Unkown
HY-112304A	(1R,2S)-NCD38 TFA	Inhibitor	/	Unkown
HY-123577	TPC-144		/	Unkown
HY-143238	FY-56	Inhibitor	/	Unkown
HY-183067A	TAS1440 benzoate		/	Unkown
HY-186116	LSD1-IN-49	Inhibitor	/	Unkown
HY-186116A	LSD1-IN-49 hydrochloride	Inhibitor	/	Unkown
HY-19612	DDP-38003	Inhibitor	/	Unkown
HY-RS07206	Kdm1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07207	Kdm1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kdm1a	NCBI	NCBI:23028