PABPC3 - poly(A) binding protein cytoplasmic 3 Gene

Also Known as PABP3; tPABP; PABPL3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5042

About PABPC3

Cytogenetic location: 13q12.13 Genomic coordinates (GRCh38): 13:25,096,136-25,099,254 (from NCBI)

This gene has 1 transcript (splice variant), 108 orthologues and 24 paralogues.

Summary

Messenger RNA stability and translation initiation are extensively under the control of poly(A)-binding proteins (PABP). See PABPC1 (MIM 604679) for background information.[supplied by OMIM, Jul 2002]

PABPC3 Products (1)

mRNA Protein Name
NM_030979.3 NP_112241.2 polyadenylate-binding protein 3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables poly(A) binding IDA
IDA: Inferred from direct assay
11328870 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PABPC3 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (13 - 83)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (101 - 168)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (193 - 261)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (296 - 363)

PABP

PABP: Poly-adenylate binding protein, unique domain (539 - 609)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 631 a.a.
Protein Preferred Names Protein Names

polyadenylate-binding protein 3

  • PABP-3

PABPC3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PABPC3 Q9H361 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra
PABPC3 Q9H361 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra
PABPC3 Q9H361 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra
PABPC3 Q9H361 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
PABPC3 Q9H361 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
PABPC3 Q9H361 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Polyposis, Skin Pigmentation, Alopecia, And Fingernail Changes

  • Cronkhite-Canada Syndrome

  • Gastric Cronkhite Canada Polyposis

  • Cronkhite-Canada Disease

  • Polyposis Skin Pigmentation Alopecia Fingernail Changes

  • Gastrointestinal Polyposis-Ectodermal Changes Syndrome

  • Gastrointestinal Polyposis-Skin Pigmentation-Alopecia-Fingernail Changes Syndrome

  • Polyposis, Gastrointestinal, With Ectodermal Changes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09949 PABPC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PABPC3 RGD RGD:1311201
Macaca mulatta PABPC3 VGNC VGNC:106280
Mus musculus PABPC3 MGD MGI:1349722
Others PABPC3 NCBI