PAEP - progestagen associated endometrial protein Gene

Also Known as GD; GdA; GdF; GdS; PEP; PAEG; PP14; ZIF-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5047

About PAEP

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:135,561,756-135,566,955 (from NCBI)

This gene has 9 transcripts (splice variants), 154 orthologues and 12 paralogues. Restricted expression toward endometrium (RPKM 125.9).

Summary

This gene is a member of the kernel lipocalin superfamily whose members share relatively low sequence similarity but have highly conserved exon/intron structure and three-dimensional protein folding. Most lipocalins are clustered on the long arm of chromosome 9. The encoded glycoprotein has been previously referred to as pregnancy-associated endometrial alpha-2-globulin, placental protein 14, and glycodelin, but has been officially named progestagen-associated endometrial protein. Three distinct forms, with identical protein backbones but different glycosylation profiles, are found in amniotic fluid, follicular fluid and seminal plasma of the reproductive system. These glycoproteins have distinct and essential roles in regulating a uterine environment suitable for pregnancy and in the timing and occurrence of the appropriate sequence of events in the fertilization process. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

PAEP Products (3)

mRNA	Protein	Name
NM_001018048.2	NP_001018058.1	glycodelin isoform 2 precursor
NM_001018049.3	NP_001018059.1	glycodelin isoform 1 precursor
NM_002571.4	NP_002562.2	glycodelin isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in apoptotic process	IDA IDA: Inferred from direct assay	18996219	GOA
involved in negative regulation of sperm capacitation	IMP IMP: Inferred from mutant phenotype	15883155	GOA
involved in positive regulation of granulocyte macrophage colony-stimulating factor production	IDA IDA: Inferred from direct assay	19945098	GOA
involved in regulation of binding of sperm to zona pellucida	IDA IDA: Inferred from direct assay	17192260	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in extracellular region	IDA IDA: Inferred from direct assay	3667877	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAEP Protein Structure

Lipocalin

0
100
180 a.a.

Protein Preferred Names	Protein Names
glycodelin	PEG

PAEP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	PAEP	P09466	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	PAEP	P09466	ARL13B	Homo sapiens	Q3SXY8	Validated Y2H	32296183
Intra	PAEP	P09466	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	PAEP	P09466	HIBADH	Homo sapiens	P31937	Y2H Array	32296183
Intra	PAEP	P09466	HIBADH	Homo sapiens	P31937	Y2H Prey Pooling	32296183
Intra	PAEP	P09466	HIBADH	Homo sapiens	P31937	Validated Y2H	32296183
Intra	PAEP	P09466	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	PAEP	P09466	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	PAEP	P09466	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	PAEP	P09466	PCDHGA4	Homo sapiens	Q9Y5G9	Y2H Prey Pooling	32296183
Intra	PAEP	P09466	PCDHGA4	Homo sapiens	Q9Y5G9	Validated Y2H	32296183
Intra	PAEP	P09466	PCDHGA4	Homo sapiens	Q9Y5G9	Y2H Array	32296183
Intra	PAEP	P09466	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	PAEP	P09466	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	PAEP	P09466	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	PAEP	P09466	AQP9	Homo sapiens	O43315	Y2H Prey Pooling	32296183
Intra	PAEP	P09466	AQP9	Homo sapiens	O43315	Y2H Array	32296183
Intra	PAEP	P09466	ERVFRD-1	Homo sapiens	P60508	Validated Y2H	32296183
Intra	PAEP	P09466	ERVFRD-1	Homo sapiens	P60508	Y2H Array	32296183
Intra	PAEP	P09466	ERVFRD-1	Homo sapiens	P60508	Y2H Prey Pooling	32296183
Intra	PAEP	P09466	GPR42	Homo sapiens	O15529	Y2H Array	32296183
Intra	PAEP	P09466	GPR42	Homo sapiens	O15529	Y2H Prey Pooling	32296183
Intra	PAEP	P09466	GRAMD2B	Homo sapiens	Q96HH9	Validated Y2H	32296183
Intra	PAEP	P09466	GRAMD2B	Homo sapiens	Q96HH9	Y2H Array	25416956
Intra	PAEP	P09466	GRAMD2B	Homo sapiens	Q96HH9	Y2H Array	32296183
Intra	PAEP	P09466	GRAMD2B	Homo sapiens	Q96HH9	Y2H Prey Pooling	25416956
Intra	PAEP	P09466	GRAMD2B	Homo sapiens	Q96HH9	Y2H Prey Pooling	32296183
Intra	PAEP	P09466	IFNLR1	Homo sapiens	Q8IU57	Y2H Prey Pooling	32296183
Intra	PAEP	P09466	IFNLR1	Homo sapiens	Q8IU57	Validated Y2H	32296183
Intra	PAEP	P09466	IFNLR1	Homo sapiens	Q8IU57	Y2H Array	32296183
Intra	PAEP	P09466	GORAB	Homo sapiens	Q5T7V8	Validated Y2H	32296183
Intra	PAEP	P09466	GORAB	Homo sapiens	Q5T7V8	Y2H Array	32296183
Intra	PAEP	P09466	GORAB	Homo sapiens	Q5T7V8	Y2H Prey Pooling	32296183
Intra	PAEP	P09466	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	PAEP	P09466	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	PAEP	P09466	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PAEP Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P71669	PAEP Protein, Human (HEK293, Myc, His)	P09466-1 (M19-F180)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P700004	PAEP Protein, Human (HEK293, His)	P09466-1 (M19-F180)	≥ 95%, as determined by reducing SDS-PAGE.

PAEP Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P82448	Glycodelin Antibody (YA2193)	WB	Human

Related Diseases

Diseases	Alias
Kleefstra Syndrome 1	9q Subtelomeric Deletion Syndrome KLEFS1 Chromosome 9q34.3 Deletion Syndrome 9q- Syndrome 9q34 Deletion Syndrome Kleefstra Syndrome Due To 9q34 Microdeletion Kleefstra Syndrome 9q-Syndrome 9qstds Kleefstra Syndrome Due To 9q Subtelomeric Deletion Kleefstra Syndrome Due To Del(9)(Q34) Kleefstra Syndrome Due To Monosomy 9q34 Chromosome 9q Subtelomeric Deletion Syndrome Kleefstra Syndrome, Type 1
Ectopic Pregnancy	Eccyesis Pregnancy Ectopic Pregnancy, Ectopic Ectopic Pregnancies Extrauterine Gestation Or Pregnancy Extrauterine Pregnancy Ep - [Ectopic Pregnancy] Ectopic Mole Aborted Ectopic Pregnancy Ruptured Ectopic Pregnancy
Submucous Uterine Fibroid	Submucous Leiomyoma Of Uterus
Ovarian Cyst	Ovarian Cysts
Endometriosis	Endometriosis, Site Unspecified Endometrial Ectopia
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Pregnancy Loss, Recurrent 1	Pregnancy Loss, Recurrent, Susceptibility To, 1 Rpl RPRGL1 Rprgl Recurrent Miscarriage Recurrent Spontaneous Abortion Abortion, Spontaneous, Recurrent Fetal Loss, Recurrent Fetal Loss, Recurrent, Susceptibility To Miscarriage, Recurrent Embryonic Loss, Recurrent Stillbirth, Recurrent Pregnancy Loss, Recurrent, 1 Recurrent Embryonic Loss Recurrent Fetal Loss Recurrent Stillbirth Spontaneous Recurrent Abortion Miscarriage Recurrent Pregnancy Loss, Recurrent, Susceptibility To, Type 1 Abortion, Habitual
Infertility
Microphthalmia, Isolated 4	Isolated Microphthalmia 4 MCOP4 Microphthalmia, Isolated, 4 Isolated Clinical Anophthalmia Microphthalmia, Isolated, Type 4
Brachydactyly, Type A1, C	Brachydactyly Type A1c BDA1C Brachydactyly A1, C Brachydactyly A1c Brachydactyly Type A1 C
Atypical Follicular Adenoma
Multiple Synostoses Syndrome	Symphalangism-Brachydactyly Syndrome Deafness-Hermann Type Symphalangism Syndrome Facio-Audio-Symphalangism Hearing Loss-Hermann Type Symphalangism Syndrome Wl Syndrome Multiple Synostosis Syndrome
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1	Eec Syndrome Rudiger Syndrome 1 Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome 1 EEC1 Eec Syndrome 1 Eec Syndrome-1 Walker-Clodius Syndrome Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Palate Syndrome Eec Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome Ectrodactyly-Cleft Lip/Palate Syndrome Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Cleft Palate Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome Ectrodactyly, Ectodermal Dysplasia, Clefting Syndrome Ectrodactyly-Cleft Lip-Palate Syndrome Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome
Proximal Symphalangism	Cushing'S Symphalangism Symphalangism, Proximal Hereditary Absence Of Proximal Interphalangeal Joints Strasburger-Hawkins-Eldridge Syndrome Strasburger-Hawkins-Eldridge-Hargrave-Mckusick Syndrome Symphalangism, Proximal, 1a Symphalangism, Proximal, 1b Vessel'S Syndrome Symphalangism, Cushing Type
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Acromesomelic Dysplasia 2b	Fibular Hypoplasia And Complex Brachydactyly Du Pan Syndrome AMD2B Dupans Acromesomelic Dysplasia-2b Fibular Aplasia-Complex Brachydactyly Syndrome
Brachydactyly, Type C	Brachydactyly Type C BDC Brachydactyly Haws Type Brachydactyly, Haws Type Brachydactyly C
Brachydactyly, Type A2	Brachydactyly Type A2 BDA2 Mohr-Wriedt Type Brachydactyly Brachymesophalangy Ii Brachymesophalangy Type 2 Brachymesophalangy 2 Brachydactyly, Mohr-Wriedt Type Brachydactyly A2
Infiltrating Angiolipoma	Angiolipoma, Infiltrating

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS09965	PAEP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17816	Paep Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24285	Paep Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PAEP	RGD	RGD:2293817
Others	PAEP	NCBI