2. Gene
  3. ARHGEF4 - Rho guanine nucleotide exchange factor 4 Gene

ARHGEF4 - Rho guanine nucleotide exchange factor 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ASEF; GEF4; STM6; ASEF1; SMIM39

Gene ID: 50649 | Gene type: protein coding

About ARHGEF4

Cytogenetic location: 2q21.1 Genomic coordinates (GRCh38): 2:130,836,914-131,047,253 (from NCBI)

This gene has 17 transcripts (splice variants) and 22 orthologues. Biased expression in brain (RPKM 13.8), skin (RPKM 13.1) and 11 other tissues.

Summary

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The protein encoded by this gene may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jun 2013]

ARHGEF4 Products(8)

mRNA Protein Name
NM_001367493.1 NP_001354422.1 rho guanine nucleotide exchange factor 4 isoform c
NM_001375900.1 NP_001362829.1 rho guanine nucleotide exchange factor 4 isoform d
NM_001375901.1 NP_001362830.1 rho guanine nucleotide exchange factor 4 isoform e
NM_001375902.1 NP_001362831.1 rho guanine nucleotide exchange factor 4 isoform f
NM_001375903.1 NP_001362832.1 rho guanine nucleotide exchange factor 4 isoform g
NM_001375904.1 NP_001362833.1 rho guanine nucleotide exchange factor 4 isoform h
NM_001395416.1 NP_001382345.1 rho guanine nucleotide exchange factor 4 isoform i
NM_015320.4 NP_056135.2 rho guanine nucleotide exchange factor 4 isoform a

ARHGEF4 Protein Structure

SH3_9

SH3_9: Variant SH3 domain (201 - 248)

RhoGEF

RhoGEF: RhoGEF domain (288 - 467)

PH

PH: PH domain (501 - 601)

  • 0
  • 200
  • 400
  • 600
  • 690 a.a.
Protein Preferred Names Protein Names

rho guanine nucleotide exchange factor 4

APC-stimulated guanine nucleotide exchange factor 1

Related Diseases

Diseases Alias
Breast Lipoma

Lipoma Of Breast
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00960 ARHGEF4 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ARHGEF4 VGNC VGNC:55325
Mus musculus ARHGEF4 MGD MGI:2442507
Felis catus ARHGEF4 VGNC VGNC:80137
Rattus norvegicus ARHGEF4 RGD RGD:1586179
Canis familiaris ARHGEF4 VGNC VGNC:54802