ARHGEF4 - Rho guanine nucleotide exchange factor 4 Gene

Also Known as ASEF; GEF4; STM6; ASEF1; SMIM39

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 50649

About ARHGEF4

Cytogenetic location: 2q21.1 Genomic coordinates (GRCh38): 2:130,836,914-131,047,253 (from NCBI)

This gene has 17 transcripts (splice variants) and 22 orthologues. Biased expression in brain (RPKM 13.8), skin (RPKM 13.1) and 11 other tissues.

Summary

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The protein encoded by this gene may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jun 2013]

ARHGEF4 Products (8)

mRNA	Protein	Name
NM_001367493.1	NP_001354422.1	rho guanine nucleotide exchange factor 4 isoform c
NM_001375900.1	NP_001362829.1	rho guanine nucleotide exchange factor 4 isoform d
NM_001375901.1	NP_001362830.1	rho guanine nucleotide exchange factor 4 isoform e
NM_001375902.1	NP_001362831.1	rho guanine nucleotide exchange factor 4 isoform f
NM_001375903.1	NP_001362832.1	rho guanine nucleotide exchange factor 4 isoform g
NM_001375904.1	NP_001362833.1	rho guanine nucleotide exchange factor 4 isoform h
NM_001395416.1	NP_001382345.1	rho guanine nucleotide exchange factor 4 isoform i
NM_015320.4	NP_056135.2	rho guanine nucleotide exchange factor 4 isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables guanyl-nucleotide exchange factor activity	IMP IMP: Inferred from mutant phenotype	17599059	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10947987	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	10947987	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in filopodium assembly	IMP IMP: Inferred from mutant phenotype	17599059	GOA
involved in lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	17599059	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGEF4 Protein Structure

SH3_9

RhoGEF

PH

0
200
400
600
690 a.a.

Protein Preferred Names	Protein Names
rho guanine nucleotide exchange factor 4	APC-stimulated guanine nucleotide exchange factor 1

ARHGEF4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ARHGEF4	Q9NR80	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	ARHGEF4	Q9NR80	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Breast Lipoma	Lipoma Of Breast

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00960	ARHGEF4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ARHGEF4	VGNC	VGNC:55325
Mus musculus	ARHGEF4	MGD	MGI:2442507
Felis catus	ARHGEF4	VGNC	VGNC:80137
Rattus norvegicus	ARHGEF4	RGD	RGD:1586179
Canis familiaris	ARHGEF4	VGNC	VGNC:54802