Fbxl3 - F-box and leucine-rich repeat protein 3 Gene

Also Known as FBK; Ovtm; Fbl3a; Fbxl3a; Play68

Species: Mus musculus

Gene Type: protein coding
Gene ID: 50789

Summary

Contributes to ubiquitin-protein transferase activity. Involved in cellular protein metabolic process; entrainment of circadian clock by photoperiod; and protein destabilization. Located in cytosol and nucleus. Is expressed in embryo; extraembryonic component; inner cell mass; and trophectoderm. Orthologous to human FBXL3 (F-box and leucine rich repeat protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Fbxl3 Products (5)

mRNA Protein Name
NM_001347600.1 NP_001334529.1 F-box/LRR-repeat protein 3 isoform 2
NM_001347601.1 NP_001334530.1 F-box/LRR-repeat protein 3 isoform 2
NM_001360341.1 NP_001347270.1 F-box/LRR-repeat protein 3 isoform 1
NM_001360342.1 NP_001347271.1 F-box/LRR-repeat protein 3 isoform 1
NM_015822.3 NP_056637.1 F-box/LRR-repeat protein 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17462724 MGI
contributes to ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
17462724 MGI
Biological Process GO Annotation Evidence References Source
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
23452855 MGI
involved in entrainment of circadian clock by photoperiod IMP
IMP: Inferred from mutant phenotype
23452855 MGI
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
17462724 MGI
involved in protein destabilization IMP
IMP: Inferred from mutant phenotype
23616524 MGI
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
23452855 MGI
involved in protein ubiquitination IMP
IMP: Inferred from mutant phenotype
26776516 MGI
involved in regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
17462724 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
23452855 MGI
located in nucleus IDA
IDA: Inferred from direct assay
17463252 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

F-box/LRR-repeat protein 3

  • F-box and leucine-rich repeat protein 3a

  • F-box/LRR-repeat protein 3A

  • protein after-hours

  • protein overtime

Fbxl3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Fbxl3 Q8C4V4 Cry1 Mus musculus P97784
Anti Tag CoIP
23452855
Intra
Fbxl3 Q8C4V4 Cry1 Mus musculus P97784
Anti Tag CoIP
17462724
Intra
Fbxl3 Q8C4V4 Cry1 Mus musculus P97784
Anti Tag CoIP
23452856
Intra
Fbxl3 Q8C4V4 Cry2 Mus musculus Q9R194
Anti Tag CoIP
17462724
Intra
Fbxl3 Q8C4V4 Cry2 Mus musculus Q9R194
Anti Tag CoIP
23452856
Intra
Fbxl3 Q8C4V4 Per2 Mus musculus O54943
Anti Tag CoIP
23452855
Cross
Fbxl3 Q8C4V4 SKP1 Homo sapiens P63208
Anti Tag CoIP
23452856
Cross
Fbxl3 Q8C4V4 CUL1 Homo sapiens Q13616
Anti Tag CoIP
23452856
Cross
Fbxl3 Q8C4V4 CUL1 Homo sapiens Q13616
BiFC
23452855
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-134194 KL201 98.18% Unkown
HY-RS04791 FBXL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22502 Fbxl3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29024 Fbxl3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fbxl3 NCBI NCBI:26224