2. Gene
  3. DYNC1LI1 - dynein cytoplasmic 1 light intermediate chain 1 Gene

DYNC1LI1 - dynein cytoplasmic 1 light intermediate chain 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LIC1; DLC-A; DNCLI1

Gene ID: 51143 | Gene type: protein coding

About DYNC1LI1

Cytogenetic location: 3p22.3 Genomic coordinates (GRCh38): 3:32,525,974-32,570,858 (from NCBI)

This gene has 8 transcripts (splice variants), 225 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 27.3), heart (RPKM 19.1) and 25 other tissues.

Summary

The protein encoded by this gene belongs to LIGHT intermediate subunit family, whose members are components of the multiprotein cytoplasmic dynein complex, which is involved in intracellular trafficking and chromosome segregation during mitosis. The protein plays a role in moving the spindle assembly checkpoint (SAC) from kinetochores to spindle poles. The protein may also mediate binding to other cargo molecules to facilitate intracellular vesicle trafficking. [provided by RefSeq, Jul 2016]

DYNC1LI1 Products(2)

mRNA Protein Name
NM_001329135.2 NP_001316064.1 cytoplasmic dynein 1 light intermediate chain 1 isoform 2
NM_016141.4 NP_057225.2 cytoplasmic dynein 1 light intermediate chain 1 isoform 1

DYNC1LI1 Protein Structure

DLIC

DLIC: Dynein light intermediate chain (DLIC) (43 - 511)

  • 0
  • 100
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  • 400
  • 523 a.a.
Protein Preferred Names Protein Names

cytoplasmic dynein 1 light intermediate chain 1

dynein light chain A

Related Diseases

Diseases Alias
Myostatin-Related Muscle Hypertrophy

Mslhp

Muscle Hypertrophy Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04085 DYNC1LI1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DYNC1LI1 VGNC VGNC:61678
Rattus norvegicus DYNC1LI1 RGD RGD:71072
Macaca mulatta DYNC1LI1 VGNC VGNC:84187
Canis familiaris DYNC1LI1 VGNC VGNC:40146
Bos taurus DYNC1LI1 VGNC VGNC:28272
Mus musculus DYNC1LI1 MGD MGI:2135610