ZNF219 - zinc finger protein 219 Gene

Also Known as ZFP219

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51222

About ZNF219

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:21,090,077-21,104,722 (from NCBI)

This gene has 13 transcripts (splice variants), 158 orthologues and 14 paralogues. Ubiquitous expression in fat (RPKM 12.4), colon (RPKM 6.8) and 22 other tissues.

Summary

This gene is a member of the Kruppel-like zinc finger gene family. The encoded protein functions as a transcriptional repressor of the high mobility group nucleosome binding domain 1 protein, which is associated with transcriptionally active chromatin. [provided by RefSeq, Apr 2017]

ZNF219 Products (3)

mRNA Protein Name
NM_001101672.2 NP_001095142.1 zinc finger protein 219
NM_001102454.2 NP_001095924.1 zinc finger protein 219
NM_016423.3 NP_057507.2 zinc finger protein 219

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
14621294 GOA
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
14621294 GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
14621294 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
14621294 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19549071 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
14621294 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
14621294 GOA
involved in regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
19549071 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
10819330 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF219 Protein Structure

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (57 - 79)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (85 - 107)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (163 - 186)

zf-H2C2_5

zf-H2C2_5: C2H2-type zinc-finger domain (190 - 213)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (274 - 296)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (302 - 324)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (512 - 535)

zf-H2C2_5

zf-H2C2_5: C2H2-type zinc-finger domain (646 - 669)

  • 0
  • 200
  • 400
  • 600
  • 722 a.a.
Protein Preferred Names Protein Names

zinc finger protein 219

ZNF219 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZNF219 Q9P2Y4 DR1 Homo sapiens Q01658
Validated Y2H
32814053
Intra
ZNF219 Q9P2Y4 DR1 Homo sapiens Q01658
Y2H Pooling
32814053
Intra
ZNF219 Q9P2Y4 DR1 Homo sapiens Q01658
Y2H Array
32814053
Intra
ZNF219 Q9P2Y4 LMO1 Homo sapiens P25800
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Frontonasal Dysplasia 1

  • Frontorhiny

  • Frontonasal Dysplasia

  • Fnd

  • Frontonasal Malformation

  • Fnm

  • Median Facial Cleft Syndrome

  • Midline Facial Cleft

  • FND1

  • Median Cleft Face Syndrome

  • Median Cleft Syndrome

  • Frontonasal Dysplasia Sequence

  • Median Facial Cleft

  • Tessier Number 0-14 And 30 Facial Cleft

  • Alx3-Related Frontonasal Dysplasia

  • Frontonasal Dysplasia Type 1

  • Isolated Median Cleft Face Syndrome

  • Doid:0081044

  • Doid:0081045

  • Dysplasia, Frontonasal, Type
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16111 ZNF219 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ZNF219 MGD MGI:1917140
Bos taurus ZNF219 VGNC VGNC:37229
Macaca mulatta ZNF219 VGNC VGNC:78876
Rattus norvegicus ZNF219 RGD RGD:1359259
Canis familiaris ZNF219 VGNC VGNC:48675
Felis catus ZNF219 VGNC VGNC:67279
Others ZNF219 NCBI