CDK17 - cyclin dependent kinase 17 Gene

Also Known as PCTK2; PCTAIRE2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5128

About CDK17

Cytogenetic location: 12q23.1 Genomic coordinates (GRCh38): 12:96,278,225-96,400,439 (from NCBI)

This gene has 12 transcripts (splice variants), 268 orthologues and 26 paralogues. Ubiquitous expression in brain (RPKM 21.3), testis (RPKM 15.1) and 24 other tissues.

Summary

The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jul 2010]

CDK17 Products (2)

mRNA	Protein	Name
NM_001170464.4	NP_001163935.1	cyclin-dependent kinase 17 isoform 2
NM_002595.5	NP_002586.2	cyclin-dependent kinase 17 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15161933	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDK17 Protein Structure

Pkinase

0
100
200
300
400
500
523 a.a.

Protein Preferred Names	Protein Names
cyclin-dependent kinase 17	PCTAIRE-motif protein kinase 2

CDK17 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDK17	Q00537	BICDL2	Homo sapiens	A1A5D9	Y2H Array	32296183
Intra	CDK17	Q00537	BICDL2	Homo sapiens	A1A5D9	Y2H Prey Pooling	32296183
Intra	CDK17	Q00537	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	33961781
Intra	CDK17	Q00537	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	CDK17	Q00537	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	CDK17	Q00537	CDK16	Homo sapiens	Q00536	Anti Tag CoIP	33961781
Intra	CDK17	Q00537	DPY30	Homo sapiens	Q9C005	Y2H Prey Pooling	32296183
Intra	CDK17	Q00537	DPY30	Homo sapiens	Q9C005	Validated Y2H	32296183
Intra	CDK17	Q00537	DPY30	Homo sapiens	Q9C005	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spastic Paraplegia 16, X-Linked	SPG16 Hereditary Spastic Paraplegia 16 X-Linked Spastic Paraplegia Type 16 Spastic Paraplegia 16, X-Linked, Complicated X-Linked Spastic Paraplegia 16 Spastic Paraplegia 16 Spastic Paraplegia-16, X-Linked, Complicated
Spastic Paraplegia 12, Autosomal Dominant	SPG12 Hereditary Spastic Paraplegia 12 Autosomal Dominant Spastic Paraplegia Type 12 Autosomal Dominant Spastic Paraplegia 12 Spastic Paraplegia 12 Spastic Paraplegia-12 Paraplegia, Spastic, Autosomal Dominant, Type 12

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14660	Dabrafenib	Degrader	99.94%	Yes

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-137346	DD-03-156		99.90%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CDK17	VGNC	VGNC:108225
Felis catus	CDK17	VGNC	VGNC:68736
Macaca mulatta	CDK17	VGNC	VGNC:71161
Rattus norvegicus	CDK17	RGD	RGD:1565593
Mus musculus	CDK17	MGD	MGI:97517
Bos taurus	CDK17	VGNC	VGNC:27120
Others	CDK17	NCBI