2. Gene
  3. BIN2 - bridging integrator 2 Gene

BIN2 - bridging integrator 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as BRAP-1

Gene ID: 51411 | Gene type: protein coding

About BIN2

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:51,281,038-51,324,668 (from NCBI)

This gene has 10 transcripts (splice variants), 267 orthologues and 3 paralogues. Broad expression in bone marrow (RPKM 30.2), spleen (RPKM 24.4) and 15 other tissues.

Summary

Enables phospholipid binding activity. Involved in several processes, including phagocytosis, engulfment; plasma membrane tubulation; and podosome assembly. Located in plasma membrane and podosome. Colocalizes with phagocytic cup. [provided by Alliance of Genome Resources, Apr 2022]

BIN2 Products(7)

mRNA Protein Name
NM_001290007.2 NP_001276936.1 bridging integrator 2 isoform 2
NM_001290008.2 NP_001276937.2 bridging integrator 2 isoform 3
NM_001290009.2 NP_001276938.1 bridging integrator 2 isoform 4
NM_001364779.1 NP_001351708.1 bridging integrator 2 isoform 5
NM_001364780.1 NP_001351709.1 bridging integrator 2 isoform 6
NM_001364781.1 NP_001351710.1 bridging integrator 2 isoform 7
NM_016293.4 NP_057377.4 bridging integrator 2 isoform 1

BIN2 Protein Structure

BAR

BAR: BAR domain (18 - 236)

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  • 565 a.a.
Protein Preferred Names Protein Names

bridging integrator 2

breast cancer associated protein BRAP1

Recombinant BIN2 Proteins

Cat. No. Product Name Accession Purity
HY-P7677 BIN2 Protein, Human (His) Q9UBW5 (M1-N244) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100462 PTP1B-IN-2 Inhibitor 99.80% Unkown
HY-139561 KDM2B-IN-2 99.60% Unkown
HY-115687 PDE4B-IN-2 Inhibitor 99.21% Unkown
HY-145894 NaPi2b-IN-2 98.93% Unkown
HY-155007 DNA gyrase B-IN-2 / Unkown
HY-137175A CDC25B-IN-2 Inhibitor 97.01% Unkown
HY-144636 Atg4B-IN-2 Inhibitor 98.03% Unkown
HY-145708 Dual AChE-MAO B-IN-2 Inhibitor / Unkown
HY-147604 Factor B-IN-2 Inhibitor / Unkown
HY-RS01505 BIN2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus BIN2 VGNC VGNC:60117
Macaca mulatta BIN2 VGNC VGNC:99898
Rattus norvegicus BIN2 RGD RGD:1306789
Bos taurus BIN2 VGNC VGNC:26498
Canis familiaris BIN2 VGNC VGNC:38459
Mus musculus BIN2 MGD MGI:3611448
Others BIN2 NCBI