BIN2 - bridging integrator 2 Gene

Also Known as BRAP-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51411

About BIN2

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:51,281,038-51,324,668 (from NCBI)

This gene has 10 transcripts (splice variants), 267 orthologues and 3 paralogues. Broad expression in bone marrow (RPKM 30.2), spleen (RPKM 24.4) and 15 other tissues.

Summary

Enables phospholipid binding activity. Involved in several processes, including phagocytosis, engulfment; plasma membrane tubulation; and podosome assembly. Located in plasma membrane and podosome. Colocalizes with phagocytic cup. [provided by Alliance of Genome Resources, Apr 2022]

BIN2 Products (7)

mRNA Protein Name
NM_001290007.2 NP_001276936.1 bridging integrator 2 isoform 2
NM_001290008.2 NP_001276937.2 bridging integrator 2 isoform 3
NM_001290009.2 NP_001276938.1 bridging integrator 2 isoform 4
NM_001364779.1 NP_001351708.1 bridging integrator 2 isoform 5
NM_001364780.1 NP_001351709.1 bridging integrator 2 isoform 6
NM_001364781.1 NP_001351710.1 bridging integrator 2 isoform 7
NM_016293.4 NP_057377.4 bridging integrator 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phospholipid binding IDA
IDA: Inferred from direct assay
23285027 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10903846 GOA
Biological Process GO Annotation Evidence References Source
involved in cell chemotaxis IMP
IMP: Inferred from mutant phenotype
23285027 GOA
involved in phagocytosis, engulfment IMP
IMP: Inferred from mutant phenotype
23285027 GOA
involved in plasma membrane tubulation IDA
IDA: Inferred from direct assay
23285027 GOA
involved in podosome assembly IMP
IMP: Inferred from mutant phenotype
23285027 GOA
Cellular Component GO Annotation Evidence References Source
colocalizes with phagocytic cup IDA
IDA: Inferred from direct assay
23285027 GOA
located in podosome IDA
IDA: Inferred from direct assay
23285027 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BIN2 Protein Structure

BAR

BAR: BAR domain (18 - 236)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 565 a.a.
Protein Preferred Names Protein Names

bridging integrator 2

  • breast cancer associated protein BRAP1

BIN2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BIN2 Q9UBW5 BIN1 Homo sapiens O00499
Anti Tag CoIP
33961781
Intra
BIN2 Q9UBW5 BIN1 Homo sapiens O00499
Anti Bait CoIP
10903846
Intra
BIN2 Q9UBW5 APPBP2 Homo sapiens Q92624
Y2H Array
32296183
Intra
BIN2 Q9UBW5 APPBP2 Homo sapiens Q92624
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BIN2 Proteins

Cat. No. Product Name Accession Purity
HY-P7677 BIN2 Protein, Human (His) Q9UBW5-1 (M1-N244) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100462 PTP1B-IN-2 Inhibitor 99.88% Unkown
HY-145894 NaPi2b-IN-2 Inhibitor 99.02% Unkown
HY-115687 PDE4B-IN-2 Inhibitor 99.59% Unkown
HY-137175A CDC25B-IN-2 Inhibitor 97.02% Unkown
HY-144636 Atg4B-IN-2 Inhibitor 98.03% Unkown
HY-155007 DNA gyrase B-IN-2 99.77% Unkown
HY-145708 Dual AChE-MAO B-IN-2 Inhibitor / Unkown
HY-147604 Factor B-IN-2 Inhibitor / Unkown
HY-RS01505 BIN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-162574 CYP11B2-IN-2 Inhibitor / Unkown
HY-RS19309 Bin2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25800 Bin2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus BIN2 VGNC VGNC:60117
Macaca mulatta BIN2 VGNC VGNC:99898
Rattus norvegicus BIN2 RGD RGD:1306789
Bos taurus BIN2 VGNC VGNC:26498
Canis familiaris BIN2 VGNC VGNC:38459
Mus musculus BIN2 MGD MGI:3611448
Others BIN2 NCBI