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YTHDF2 - YTH N6-methyladenosine RNA binding protein 2 Gene

Also Known as DF2; CAHL; HGRG8; NY-REN-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51441

About YTHDF2

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:28,736,624-28,769,775 (from NCBI)

This gene has 9 transcripts (splice variants), 214 orthologues and 3 paralogues. Ubiquitous expression in bone marrow (RPKM 23.8), testis (RPKM 20.2) and 25 other tissues.

Summary

This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in Plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012]

YTHDF2 Products (3)

mRNA	Protein	Name
NM_001172828.2	NP_001166299.1	YTH domain-containing family protein 2 isoform 2
NM_001173128.2	NP_001166599.1	YTH domain-containing family protein 2 isoform 1
NM_016258.3	NP_057342.2	YTH domain-containing family protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables C5-methylcytidine-containing RNA reader activity	IDA IDA: Inferred from direct assay	31815440	GOA
enables N6-methyladenosine-containing RNA reader activity	IDA IDA: Inferred from direct assay	22575960	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24965446	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mRNA catabolic process	IDA IDA: Inferred from direct assay	27558897	GOA
involved in mRNA destabilization	IDA IDA: Inferred from direct assay	27558897	GOA
involved in mRNA destabilization	IMP IMP: Inferred from mutant phenotype	28106072	GOA
involved in negative regulation of stem cell differentiation	IMP IMP: Inferred from mutant phenotype	32169943	GOA
involved in negative regulation of type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	30559377	GOA
involved in organelle assembly	IDA IDA: Inferred from direct assay	31292544	GOA
involved in positive regulation of cap-independent translational initiation	IDA IDA: Inferred from direct assay	26458103	GOA
NOT involved in positive regulation of translational initiation	IDA IDA: Inferred from direct assay	32492408	GOA
involved in regulation of mRNA stability	IDA IDA: Inferred from direct assay	32492408	GOA
involved in regulation of mRNA stability	IMP IMP: Inferred from mutant phenotype	24284625	GOA
involved in regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	32169943	GOA
involved in regulation of rRNA processing	IMP IMP: Inferred from mutant phenotype	31815440	GOA
involved in stress granule assembly	IDA IDA: Inferred from direct assay	32451507	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in P-body	IDA IDA: Inferred from direct assay	24284625	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	32492408	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	31292544	GOA
located in cytosol	IDA IDA: Inferred from direct assay	26458103	GOA
located in nucleus	IDA IDA: Inferred from direct assay	26458103	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

YTHDF2 Protein Structure

YTH

0
100
200
300
400
500
579 a.a.

Protein Preferred Names	Protein Names
YTH domain-containing family protein 2	9430020E02Rik

YTHDF2 Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P86454	YTHDF2 Antibody (YA6146)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Myeloid Leukemia	Myeloid Leukaemia Leukaemia Myelogenous Leukemia Myelogenous Myeloid Granulocytic Leukaemia Myeloid Granulocytic Leukemia Non-Lymphocytic Leukemia Leukemia, Myeloid Granulocytic Leukaemia Myelogenous Leukaemia Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Ocular Melanoma	Intraocular Melanoma Uveal Melanoma Eye Melanoma Melanoma Of Eye Melanoma Of The Uvea Malignant Melanoma Of Eye
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-154919	DC-Y13-27	Inhibitor	99.52%	Unkown
HY-137341	SK-3-91	Degrader	98.33%	Unkown
HY-173008	YTHDF2-IN-1	Inhibitor	99.42%	Unkown
HY-169396	TAE648	Inhibitor	99.50%	Unkown
HY-176848	SKLB-Y13	Inhibitor	98.44%	Unkown
HY-174982	YTHDF2 ligand-1	Ligand	98.83%	Unkown
HY-168610	YTH-IN-1	Inhibitor	98.66%	Unkown
HY-RS15938	YTHDF2 Human Pre-designed siRNA Set A	Inhibitor	/	Unkown
HY-175885	PROTAC FTO degrader 1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	YTHDF2	VGNC	VGNC:37042
Mus musculus	YTHDF2	MGD	MGI:2444233
Felis catus	YTHDF2	VGNC	VGNC:67152
Macaca mulatta	YTHDF2	VGNC	VGNC:79912
Rattus norvegicus	YTHDF2	RGD	RGD:1311321
Canis familiaris	YTHDF2	VGNC	VGNC:48506
Others	YTHDF2	NCBI