YTHDF2 ligand-1
Based on 1 Customer Validation
YTHDF2 ligand-1 (Compound 23) is a competitive, selective, and high-affinity YTHDF2 ligand with an IC50 of 11 μM and a Kd of 1.3 μM. YTHDF2 ligand-1 competes with m6A-RNA for binding to YTHDF2. YTHDF2 ligand-1 is applicable for cancer research.
For research use only. We do not sell to patients.
- Purity : 98.83%
- CAS No.: 3093182-34-1
- Formula: C14H12N4O2S2
- Molecular Weight:332.40
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
YTHDF2 11 μM (IC50) |
YTHDF2 1.3 μM (Kd) |
In Vitro
YTHDF2 ligand-1 binds strongly to YTHDF2 with an IC50 of 11 μM, and exhibits high selectivity for YTHDF1 and YTHDF3[1].
YTHDF2 ligand-1 (1 h) binds to YTHDF2 with a Kd value of 1.3 μM and exhibits high selectivity, showing approximately 100-fold lower affinity for YTHDC1 and approximately 350-fold lower affinity for YTHDC2[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 3093182-34-1
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Appearance Solid
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Molecular Weight 332.40
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Formula C14H12N4O2S2
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Color White to off-white
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SMILES
CC1=C(SC2=C1C(NC(N2)=S)=O)C(NCC3=CN=CC=C3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
YTHDF2 ligand-1 Related Classifications
HY-174982 Related Classifications
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