CYRIB - CYFIP related Rac1 interactor B Gene

Also Known as L1; CYRI; BM-009; CYRI-B; FAM49B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51571

About CYRIB

Cytogenetic location: 8q24.21 Genomic coordinates (GRCh38): 8:129,839,593-130,017,129 (from NCBI)

This gene has 31 transcripts (splice variants), 274 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 26.7), appendix (RPKM 26.4) and 24 other tissues.

Summary

Enables small GTPase binding activity. Involved in several processes, including cellular response to molecule of Bacterial origin; negative regulation of small GTPase mediated signal transduction; and regulation of organelle organization. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

CYRIB Products (78)

mRNA Protein Name
NM_001256763.2 NP_001243692.1 CYFIP-related Rac1 interactor B isoform 1
NM_001330612.2 NP_001317541.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353242.2 NP_001340171.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353243.2 NP_001340172.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353244.2 NP_001340173.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353245.1 NP_001340174.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353246.1 NP_001340175.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353247.1 NP_001340176.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353248.2 NP_001340177.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353249.1 NP_001340178.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353250.1 NP_001340179.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353251.1 NP_001340180.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353252.1 NP_001340181.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353253.1 NP_001340182.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353254.2 NP_001340183.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353255.1 NP_001340184.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353256.2 NP_001340185.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353257.2 NP_001340186.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353258.2 NP_001340187.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353259.2 NP_001340188.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353260.2 NP_001340189.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353261.2 NP_001340190.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353262.2 NP_001340191.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353263.2 NP_001340192.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353264.2 NP_001340193.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353265.2 NP_001340194.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353266.2 NP_001340195.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353267.2 NP_001340196.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353268.2 NP_001340197.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353269.1 NP_001340198.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353270.1 NP_001340199.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353271.1 NP_001340200.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353272.1 NP_001340201.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353273.1 NP_001340202.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353274.1 NP_001340203.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353275.1 NP_001340204.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353276.2 NP_001340205.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353277.1 NP_001340206.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353278.1 NP_001340207.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353279.1 NP_001340208.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353280.1 NP_001340209.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353281.1 NP_001340210.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353282.2 NP_001340211.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353283.2 NP_001340212.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353284.2 NP_001340213.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353285.2 NP_001340214.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353286.2 NP_001340215.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353287.2 NP_001340216.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353288.2 NP_001340217.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353289.2 NP_001340218.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353290.2 NP_001340219.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353291.2 NP_001340220.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353292.2 NP_001340221.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353293.2 NP_001340222.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353294.2 NP_001340223.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353295.2 NP_001340224.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353296.2 NP_001340225.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353297.2 NP_001340226.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353298.2 NP_001340227.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353299.2 NP_001340228.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353300.2 NP_001340229.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353301.2 NP_001340230.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353302.1 NP_001340231.1 CYFIP-related Rac1 interactor B isoform 3
NM_001353303.1 NP_001340232.1 CYFIP-related Rac1 interactor B isoform 3
NM_001353304.1 NP_001340233.1 CYFIP-related Rac1 interactor B isoform 3
NM_001353305.1 NP_001340234.1 CYFIP-related Rac1 interactor B isoform 3
NM_001353306.2 NP_001340235.1 CYFIP-related Rac1 interactor B isoform 3
NM_001353307.2 NP_001340236.1 CYFIP-related Rac1 interactor B isoform 3
NM_001353308.1 NP_001340237.1 CYFIP-related Rac1 interactor B isoform 3
NM_001353309.1 NP_001340238.1 CYFIP-related Rac1 interactor B isoform 3
NM_001353310.2 NP_001340239.1 CYFIP-related Rac1 interactor B isoform 3
NM_001353311.2 NP_001340240.1 CYFIP-related Rac1 interactor B isoform 3
NM_001353312.2 NP_001340241.1 CYFIP-related Rac1 interactor B isoform 3
NM_001353313.2 NP_001340242.1 CYFIP-related Rac1 interactor B isoform 3
NM_001353314.2 NP_001340243.1 CYFIP-related Rac1 interactor B isoform 3
NM_001353315.2 NP_001340244.1 CYFIP-related Rac1 interactor B isoform 3
NM_001353316.2 NP_001340245.1 CYFIP-related Rac1 interactor B isoform 4
NM_016623.5 NP_057707.3 CYFIP-related Rac1 interactor B isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables small GTPase binding IPI
IPI: Inferred from physical interaction
30250061 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to molecule of bacterial origin IMP
IMP: Inferred from mutant phenotype
31285585 GOA
involved in negative regulation of actin filament polymerization IMP
IMP: Inferred from mutant phenotype
30250061 GOA
involved in negative regulation of small GTPase mediated signal transduction IMP
IMP: Inferred from mutant phenotype
30250061 GOA
involved in regulation of cell migration IMP
IMP: Inferred from mutant phenotype
30250061 GOA
involved in regulation of chemotaxis IMP
IMP: Inferred from mutant phenotype
30250061 GOA
involved in regulation of establishment of cell polarity IMP
IMP: Inferred from mutant phenotype
30250061 GOA
involved in regulation of mitochondrial fission IMP
IMP: Inferred from mutant phenotype
29059164 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
29059164 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYRIB Protein Structure

DUF1394

DUF1394: Protein of unknown function (DUF1394) (17 - 320)

  • 0
  • 100
  • 200
  • 300
  • 324 a.a.
Protein Preferred Names Protein Names

CYFIP-related Rac1 interactor B

  • FAM49B/JPH1 fusion

CYRIB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CYRIB Q9NUQ9 BAG6 Homo sapiens P46379-2
Y2H Pooling
32814053
Intra
CYRIB Q9NUQ9 BAG6 Homo sapiens P46379-2
Validated Y2H
32814053
Intra
CYRIB Q9NUQ9 BAG6 Homo sapiens P46379-2
Y2H Array
32814053
Intra
CYRIB Q9NUQ9 HIP1 Homo sapiens O00291
Y2H Prey Pooling
32296183
Intra
CYRIB Q9NUQ9 HIP1 Homo sapiens O00291
Y2H Array
32296183
Intra
CYRIB Q9NUQ9 NIF3L1 Homo sapiens Q9GZT8
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cardiomyopathy, Dilated, 3b

  • Dilated Cardiomyopathy 3b

  • CMD3B

  • X-Linked Dilated Cardiomyopathy

  • Xlcm

  • Dmd-Associated Dilated Cardiomyopathy

  • Cardiomyopathy, Dilated, X-Linked

  • Dmd-Related Dilated Cardiomyopathy

  • Xldc

  • Cardiomyopathy, Dilated, X-Linked 3b

  • Cardiomyopathy, Dilated, Type 3b
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03492 CYRIB Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CYRIB RGD RGD:1307697
Mus musculus CYRIB MGD MGI:1923520
Felis catus CYRIB VGNC VGNC:62115
Canis familiaris CYRIB VGNC VGNC:40686
Macaca mulatta CYRIB VGNC VGNC:72345
Bos taurus CYRIB VGNC VGNC:28819
Others CYRIB NCBI