ARID4B - AT-rich interaction domain 4B Gene

Also Known as BCAA; BRCAA1; RBP1L1; SAP180; RBBP1L1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51742

About ARID4B

Cytogenetic location: 1q42.3 Genomic coordinates (GRCh38): 1:235,166,902-235,328,179 (from NCBI)

This gene has 13 transcripts (splice variants), 218 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 12.1), lymph node (RPKM 11.3) and 25 other tissues.

Summary

This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, Apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast Cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]

ARID4B Products (3)

mRNA Protein Name
NM_001206794.2 NP_001193723.1 AT-rich interactive domain-containing protein 4B isoform 1
NM_016374.6 NP_057458.4 AT-rich interactive domain-containing protein 4B isoform 1
NM_031371.4 NP_112739.2 AT-rich interactive domain-containing protein 4B isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables DNA binding EXP
EXP: Inferred from Experiment
33675746 GOA
enables DNA binding IMP
IMP: Inferred from mutant phenotype
33675746 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20195357 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARID4B Protein Structure

RBB1NT

RBB1NT: RBB1NT (NUC162) domain (166 - 264)

ARID

ARID: ARID/BRIGHT DNA binding domain (307 - 394)

Tudor-knot

Tudor-knot: RNA binding activity-knot of a chromodomain (572 - 624)

  • 0
  • 300
  • 600
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  • 1200
  • 1312 a.a.
Protein Preferred Names Protein Names

AT-rich interactive domain-containing protein 4B

  • 180 kDa Sin3-associated polypeptide

ARID4B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ARID4B Q4LE39 ETS1 Homo sapiens P14921
TAP
20195357
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Retinoblastoma

  • RB

  • Trilateral Retinoblastoma

  • RB1

  • Retinoblastoma, Trilateral

  • Neuroblastoma Of Retina

  • Rb - Retinoblastoma

  • Eye Cancer, Retinoblastoma

  • Retinal Cancer

  • Retinal Tumor

  • Glioma, Retinal

  • Non-Hereditary Retinoblastoma

  • Childhood Cancer Retinoblastoma

  • Malignant Neoplasm Of Retina

  • Retinal Neoplasms
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00972 ARID4B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ARID4B VGNC VGNC:38099
Bos taurus ARID4B VGNC VGNC:26130
Rattus norvegicus ARID4B RGD RGD:619919
Mus musculus ARID4B MGD MGI:2137512
Felis catus ARID4B VGNC VGNC:59917
Macaca mulatta ARID4B VGNC VGNC:69831
Others ARID4B NCBI