ERAP1 - endoplasmic reticulum aminopeptidase 1 Gene

Also Known as ALAP; A-LAP; ARTS1; ERAAP; APPILS; ARTS-1; ERAAP1; PILSAP; PILS-AP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51752

About ERAP1

Cytogenetic location: 5q15 Genomic coordinates (GRCh38): 5:96,760,813-96,935,854 (from NCBI)

This gene has 9 transcripts (splice variants), 228 orthologues, 11 paralogues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 18.4), duodenum (RPKM 14.7) and 25 other tissues.

Summary

The protein encoded by this gene is an Aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]

ERAP1 Products (4)

mRNA	Protein	Name
NM_001040458.3	NP_001035548.1	endoplasmic reticulum aminopeptidase 1 isoform b precursor
NM_001198541.3	NP_001185470.1	endoplasmic reticulum aminopeptidase 1 isoform b precursor
NM_001349244.2	NP_001336173.1	endoplasmic reticulum aminopeptidase 1 isoform a precursor
NM_016442.5	NP_057526.3	endoplasmic reticulum aminopeptidase 1 isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables aminopeptidase activity	IDA IDA: Inferred from direct assay	10220586	GOA
enables endopeptidase activity	EXP EXP: Inferred from Experiment	12436109	GOA
enables interleukin-6 receptor binding	IPI IPI: Inferred from physical interaction	12748171	GOA
enables metalloexopeptidase activity	IDA IDA: Inferred from direct assay	10220586	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15908954	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in membrane protein ectodomain proteolysis	IDA IDA: Inferred from direct assay	12748171	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular region	IDA IDA: Inferred from direct assay	11056387	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ERAP1 Protein Structure

Peptidase_M1

ERAP1_C

0
200
400
600
800
941 a.a.

Protein Preferred Names	Protein Names
endoplasmic reticulum aminopeptidase 1	adipocyte-derived leucine aminopeptidase

ERAP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ERAP1	Q9NZ08	ERAP2	Homo sapiens	Q6P179	Confocal	15908954
Intra	ERAP1	Q9NZ08	ERAP2	Homo sapiens	Q6P179	Anti Bait CoIP	15908954

Cross: Cross-species interaction Intra: Intraspecies interaction

ERAP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82414	ERAP1 Antibody (YA2159)	WB, IHC-P	Human, Rat
HY-P82414A	ERAP1 Antibody (YA2159)(PBS only)	WB, IHC-P	Human, Rat

Related Diseases

Diseases	Alias
Peeling Skin With Leukonychia, Acral Punctate Keratoses, Cheilitis, And Knuckle Pads	PLACK Peeling Skin-Leukonychia-Acral Punctate Keratoses-Cheilitis-Knuckle Pads Syndrome Plack Syndrome
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behçet'S Disease Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease
Birdshot Chorioretinopathy	Birdshot Chorioretinitis Bscr Birdshot Retinochoroiditis Birdshot Retinochoroidopathy Vitiliginous Choroiditis Multiple Small, Cream-Colored Lesions, Symmetrically Scattered Mainly Around The Optic Disk
Spondylitis
Juvenile Ankylosing Spondylitis
Anterior Uveitis	Iridocyclitis Uveitis, Anterior Acute Anterior Uveitis Uveokeratitis Keratouveitis Cyclitis Intraocular Inflammation Kerato-Uveitis Keratoiritis Iritis Uveitis Nos Uveal Inflammation Anterior Chamber Cell
Spondyloarthropathy	Spondylarthropathies Spondarthropathy Spondylarthrosis Spondyloarthropathy, Susceptibility To Spondylarthritis
Iritis
Enthesopathy	Rheumatism
Panuveitis	Diffuse Uveitis Total Uveitis Inflammation Of The Whole Uveal Tract
Posterior Uveitis	Uveitis, Posterior Choroiditis Uveitis Posterior
Spondyloarthropathy 1	Ankylosing Spondylitis Spondyloarthropathy, Susceptibility To, 1 SPDA1 Marie-Strumpell Spondylitis Bechterew Syndrome Spa Spondylarthritis Ankylopoietica Reiter Syndrome Ankylosing Spondylitis, Susceptibility To Bekhterev Syndrome Bekhterev'S Disease Marie-Strumpell Disease Axial Spondylarthritis Bechterew Disease Marie-Struempell Disease Spondylitis Ankylopoietica Spondyloarthritis Spondyloarthritis Ankylopoietica Spas Ankylosing Spondylarthritis Psoriatic Arthritis Reactive Arthritis Rheumatoid Spondylitis Spondylitis Ankylosans Spondylitis Ankylosing Spondylitis, Ankylosing Spondylarthropathies Arthritis, Psoriatic Arthritis, Reactive
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Autoimmune Disease Of Cardiovascular System
Psoriasis 2	PSORS2 Psoriasis Psoriasis Vulgaris Pv Psoriasis, Susceptibility To, Type 2
Ankylosis
Reactive Arthritis	Postdysenteric Arthropathy Reiter Disease Pira Reiter Syndrome Reiters Syndrome Arthritis, Reactive Fiessinger Leroy Reiter Syndrome Post-Bacterial Arthropathy Reiter'S Disease Post-Infectious Arthritis Post-Infectious Reactive Arthropathy Reiter'S Syndrome Arthritis Urethritica Fiessinger-Leroy Disease Polyarthritis Enterica Venereal Arthritis Arthritis Reactive Post-Dysenteric Arthropathy Arthritis, Venereal
Iridocyclitis	Primary Iridocyclitis
Hypopyon
Uveal Disease	Uveal Diseases
Autoimmune Disease Of Skin And Connective Tissue

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-133125	ERAP1-IN-1	Inhibitor	98.77%	Unkown
HY-139907B	DG013A formate	Inhibitor	99.57%	Unkown
HY-169915	ERAP1 modulator-2	Inhibitor	98.93%	Unkown
HY-139907C	DG013B formate	Control	/	Unkown
HY-139907	DG013A	Inhibitor	/	Unkown
HY-169913	ERAP1 modulator-1	Modulator	/	Unkown
HY-169936	ERAP1-IN-3	Inhibitor	/	Unkown
HY-173022	BDM_92499	Inhibitor	/	Unkown
HY-179625	GSK235	Inhibitor	/	Unkown
HY-183267	ERAP1-IN-4	Inhibitor	/	Unkown
HY-RS04463	ERAP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-139907A	DG013B	Control	/	Unkown
HY-168181	ERAP1-IN-2	Inhibitor	/	Unkown
HY-RS17658	Erap1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24119	Erap1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ERAP1	MGD	MGI:1933403
Canis familiaris	ERAP1	VGNC	VGNC:40433
Felis catus	ERAP1	VGNC	VGNC:61926
Bos taurus	ERAP1	VGNC	VGNC:28560
Macaca mulatta	ERAP1	VGNC	VGNC:72066
Rattus norvegicus	ERAP1	RGD	RGD:708542
Others	ERAP1	NCBI