ERAP1 - endoplasmic reticulum aminopeptidase 1 Gene

Homo sapiens

Also known as ALAP; A-LAP; ARTS1; ERAAP; APPILS; ARTS-1; ERAAP1; PILSAP; PILS-AP

Gene ID: 51752 | Gene type: protein coding

About ERAP1

Cytogenetic location: 5q15 Genomic coordinates (GRCh38): 5:96,760,813-96,935,854 (from NCBI)

This gene has 9 transcripts (splice variants), 228 orthologues, 11 paralogues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 18.4), duodenum (RPKM 14.7) and 25 other tissues.

Summary

The protein encoded by this gene is an Aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]

ERAP1 Products(4)

mRNA	Protein	Name
NM_001040458.3	NP_001035548.1	endoplasmic reticulum aminopeptidase 1 isoform b precursor
NM_001198541.3	NP_001185470.1	endoplasmic reticulum aminopeptidase 1 isoform b precursor
NM_001349244.2	NP_001336173.1	endoplasmic reticulum aminopeptidase 1 isoform a precursor
NM_016442.5	NP_057526.3	endoplasmic reticulum aminopeptidase 1 isoform a precursor

ERAP1 Protein Structure

Peptidase_M1

ERAP1_C

0
200
400
600
800
941 a.a.

Protein Preferred Names

Protein Names

endoplasmic reticulum aminopeptidase 1

adipocyte-derived leucine aminopeptidase

Related Diseases

Diseases

Alias

Peeling Skin With Leukonychia, Acral Punctate Keratoses, Cheilitis, And Knuckle Pads

PLACK	Peeling Skin-Leukonychia-Acral Punctate Keratoses-Cheilitis-Knuckle Pads Syndrome
Plack Syndrome

Behcet Syndrome

Behcet Disease	Behcet'S Syndrome
Behcet'S Disease	Behçet Disease
Bd	Adamantiades-Behcet Disease
Triple Symptom Complex	Behçet'S Disease
Behet'S Syndrome	Bd Syndrome
Behçet Syndrome	Behçet'S Syndrome
Behcet Triple Symptom Complex	Malignant Aphthosis
Old Silk Route Disease	Adamantiades-Behçet Disease

Birdshot Chorioretinopathy

Birdshot Chorioretinitis	Bscr
Birdshot Retinochoroiditis	Birdshot Retinochoroidopathy
Vitiliginous Choroiditis	Multiple Small, Cream-Colored Lesions, Symmetrically Scattered Mainly Around The Optic Disk

Spondylitis

Juvenile Ankylosing Spondylitis

Anterior Uveitis

Iridocyclitis	Uveitis, Anterior
Acute Anterior Uveitis	Uveokeratitis
Keratouveitis	Cyclitis
Intraocular Inflammation	Kerato-Uveitis
Keratoiritis	Iritis
Uveitis Nos	Uveal Inflammation
Anterior Chamber Cell

Spondyloarthropathy

Spondylarthropathies	Spondarthropathy
Spondylarthrosis	Spondyloarthropathy, Susceptibility To
Spondylarthritis

Iritis

Enthesopathy

Rheumatism

Panuveitis

Diffuse Uveitis	Total Uveitis
Inflammation Of The Whole Uveal Tract

Posterior Uveitis

Uveitis, Posterior	Choroiditis
Uveitis Posterior

Spondyloarthropathy 1

Ankylosing Spondylitis	Spondyloarthropathy, Susceptibility To, 1
SPDA1	Marie-Strumpell Spondylitis
Bechterew Syndrome	Spa
Spondylarthritis Ankylopoietica	Reiter Syndrome
Ankylosing Spondylitis, Susceptibility To	Bekhterev Syndrome
Bekhterev'S Disease	Marie-Strumpell Disease
Axial Spondylarthritis	Bechterew Disease
Marie-Struempell Disease	Spondylitis Ankylopoietica
Spondyloarthritis	Spondyloarthritis Ankylopoietica
Spas	Ankylosing Spondylarthritis
Psoriatic Arthritis	Reactive Arthritis
Rheumatoid Spondylitis	Spondylitis Ankylosans
Spondylitis Ankylosing	Spondylitis, Ankylosing
Spondylarthropathies	Arthritis, Psoriatic
Arthritis, Reactive

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Autoimmune Disease Of Cardiovascular System

Psoriasis 2

PSORS2	Psoriasis
Psoriasis Vulgaris	Pv
Psoriasis, Susceptibility To, Type 2

Ankylosis

Reactive Arthritis

Postdysenteric Arthropathy	Reiter Disease
Pira	Reiter Syndrome
Reiters Syndrome	Arthritis, Reactive
Fiessinger Leroy Reiter Syndrome	Post-Bacterial Arthropathy
Reiter'S Disease	Post-Infectious Arthritis
Post-Infectious Reactive Arthropathy	Reiter'S Syndrome
Arthritis Urethritica	Fiessinger-Leroy Disease
Polyarthritis Enterica	Venereal Arthritis
Arthritis Reactive	Post-Dysenteric Arthropathy
Arthritis, Venereal

Iridocyclitis

Primary Iridocyclitis

Hypopyon

Uveal Disease

Uveal Diseases

Autoimmune Disease Of Skin And Connective Tissue

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-133125	ERAP1-IN-1	98.79%	Unkown
HY-139907	DG013A	/	Unkown
HY-RS04463	ERAP1 Human Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ERAP1	MGD	MGI:1933403
Canis familiaris	ERAP1	VGNC	VGNC:40433
Felis catus	ERAP1	VGNC	VGNC:61926
Bos taurus	ERAP1	VGNC	VGNC:28560
Macaca mulatta	ERAP1	VGNC	VGNC:72066
Rattus norvegicus	ERAP1	RGD	RGD:708542

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