PIGF - phosphatidylinositol glycan anchor biosynthesis class F Gene

Also Known as OORS

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5281

About PIGF

Cytogenetic location: 2p21 Genomic coordinates (GRCh38): 2:46,580,937-46,617,041 (from NCBI)

This gene has 7 transcripts (splice variants), 217 orthologues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 42.1), heart (RPKM 35.0) and 25 other tissues.

Summary

This gene encodes a protein involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor, a glycolipid containing three mannose molecules in its core backbone, is found on many blood cells where it serves to anchor proteins to the cell surface. The encoded protein and another GPI synthesis protein, PIGO, function in the transfer of ethanolaminephosphate to the third mannose in GPI. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

PIGF Products (2)

mRNA Protein Name
NM_002643.4 NP_002634.1 phosphatidylinositol-glycan biosynthesis class F protein isoform 1
NM_173074.3 NP_775097.1 phosphatidylinositol-glycan biosynthesis class F protein isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in GPI anchor biosynthetic process IMP
IMP: Inferred from mutant phenotype
33386993 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIGF Protein Structure

PIG-F

PIG-F: GPI biosynthesis protein family Pig-F (13 - 206)

  • 0
  • 100
  • 200
  • 219 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol-glycan biosynthesis class F protein

  • GPI11 homolog

PIGF Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PIGF Q07326 LYVE1 Homo sapiens Q9Y5Y7
Validated Y2H
32296183
Intra
PIGF Q07326 LYVE1 Homo sapiens Q9Y5Y7
Y2H Array
32296183
Intra
PIGF Q07326 LYVE1 Homo sapiens Q9Y5Y7
Y2H Prey Pooling
32296183
Intra
PIGF Q07326 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
PIGF Q07326 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
PIGF Q07326 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra
PIGF Q07326 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra
PIGF Q07326 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
PIGF Q07326 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
PIGF Q07326 TMEM130 Homo sapiens Q8N3G9
Y2H Prey Pooling
32296183
Intra
PIGF Q07326 TMEM130 Homo sapiens Q8N3G9
Y2H Array
32296183
Intra
PIGF Q07326 TMEM130 Homo sapiens Q8N3G9
Validated Y2H
32296183
Intra
PIGF Q07326 TMEM86B Homo sapiens Q8N661
Y2H Array
32296183
Intra
PIGF Q07326 TMEM86B Homo sapiens Q8N661
Validated Y2H
32296183
Intra
PIGF Q07326 TMEM86B Homo sapiens Q8N661
Y2H Prey Pooling
32296183
Intra
PIGF Q07326 MANBAL Homo sapiens Q9NQG1
Validated Y2H
32296183
Intra
PIGF Q07326 MANBAL Homo sapiens Q9NQG1
Y2H Array
32296183
Intra
PIGF Q07326 TIMMDC1 Homo sapiens Q9NPL8
Y2H Array
32296183
Intra
PIGF Q07326 TIMMDC1 Homo sapiens Q9NPL8
Validated Y2H
32296183
Intra
PIGF Q07326 TIMMDC1 Homo sapiens Q9NPL8
Y2H Prey Pooling
32296183
Intra
PIGF Q07326 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
PIGF Q07326 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra
PIGF Q07326 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Onychodystrophy, Osteodystrophy, Impaired Intellectual Development, And Seizures Syndrome

  • OORS

  • Oors Syndrome

  • Glycosylphosphatidylinositol Biosynthesis Defect 24

  • Gpibd24
Pre-Eclampsia

  • Preeclampsia

  • Gestational Hypertension

  • Hypertension Induced By Pregnancy

  • Pre-Eclamptic Toxaemia

  • Pregnancy Associated Hypertension

  • Proteinuric Hypertension Of Pregnancy

  • Hypertension, Pregnancy-Induced, Susceptibility To

  • Preeclampsia/Eclampsia

  • Pregnancy Toxemia

  • Toxaemia Of Pregnancy

  • Gestational Proteinuric Hypertension

  • Pregnancy-Induced Hypertension

  • Toxemia Of Pregnancy

  • Preeclampsia, Susceptibility To

  • Transient Hypertension Of Pregnancy

  • Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria

  • Gestational Hypertension Nos

  • Mild Proteinuric Hypertension Of Pregnancy

  • Pih - [Pregnancy-Induced Hypertension]

  • Pregnancy-Induced Hypertension Nos

  • Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria

  • Pe - [Pre-Eclampsia]

  • Pre-Eclampsia Nos

  • Pre-Eclamptic Nos

  • Pregnancy Pre-Eclampsia

  • Puerperal Pre-Eclampsia

  • Pre-Eclampsia Toxaemia

  • Toxaemia In Pregnancy

  • Pet - [Pre-Eclamptic Toxaemia]

  • Maternal Toxaemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10831 GNQWFI Antagonist 99.45% Unkown
HY-RS10381 PGF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10490 PIGF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18329 Pgf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20325 Pigf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26833 Pigf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PIGF MGD MGI:99462
Canis familiaris PIGF VGNC VGNC:44532
Bos taurus PIGF VGNC VGNC:32868
Felis catus PIGF VGNC VGNC:81148
Rattus norvegicus PIGF RGD RGD:1584658
Macaca mulatta PIGF VGNC VGNC:81499
Others PIGF NCBI