ZFYVE1 - zinc finger FYVE-type containing 1 Gene

Also Known as SR3; DFCP1; TAFF1; ZNFN2A1; PPP1R172

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 53349

About ZFYVE1

Cytogenetic location: 14q24.2 Genomic coordinates (GRCh38): 14:72,969,445-73,027,106 (from NCBI)

This gene has 9 transcripts (splice variants), 263 orthologues and 13 paralogues. Ubiquitous expression in thyroid (RPKM 7.4), kidney (RPKM 6.4) and 25 other tissues.

Summary

The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

ZFYVE1 Products (4)

mRNA	Protein	Name
NM_001281734.2	NP_001268663.1	zinc finger FYVE domain-containing protein 1 isoform 3
NM_001281735.1	NP_001268664.1	zinc finger FYVE domain-containing protein 1 isoform 2
NM_021260.4	NP_067083.1	zinc finger FYVE domain-containing protein 1 isoform 1
NM_178441.2	NP_848535.1	zinc finger FYVE domain-containing protein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 1-phosphatidylinositol binding	IDA IDA: Inferred from direct assay	11256955	GOA
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA IDA: Inferred from direct assay	11804589	GOA
enables phosphatidylinositol-3,4-bisphosphate binding	IDA IDA: Inferred from direct assay	11804589	GOA
enables phosphatidylinositol-3-phosphate binding	IDA IDA: Inferred from direct assay	31293035	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19389623	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to starvation	IDA IDA: Inferred from direct assay	25578879	GOA
involved in lipid droplet formation	IMP IMP: Inferred from mutant phenotype	30970241	GOA
involved in macroautophagy	IDA IDA: Inferred from direct assay	25578879	GOA
involved in positive regulation by host of viral genome replication	IDA IDA: Inferred from direct assay	35551511	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	25876663	GOA
located in Golgi stack	IDA IDA: Inferred from direct assay	11256955	GOA
located in autophagosome	IDA IDA: Inferred from direct assay	22456507	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	11739631	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	30970241	GOA
located in extrinsic component of omegasome membrane	IDA IDA: Inferred from direct assay	19898463	GOA
located in lipid droplet	IDA IDA: Inferred from direct assay	30970241	GOA
colocalizes with membrane	IDA IDA: Inferred from direct assay	25578879	GOA
located in mitochondria-associated endoplasmic reticulum membrane contact site	IDA IDA: Inferred from direct assay	23455425	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	25876663	GOA
located in omegasome	IDA IDA: Inferred from direct assay	24954904	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	11739631	GOA
located in phagophore assembly site	IDA IDA: Inferred from direct assay	23455425	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZFYVE1 Protein Structure

FYVE

0
200
400
600
777 a.a.

Protein Preferred Names	Protein Names
zinc finger FYVE domain-containing protein 1	double FYVE-containing protein 1

ZFYVE1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ZFYVE1	Q9HBF4	PPP1CA	Homo sapiens	P62136	Far-WB	19389623

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Argyll Robertson Pupil	Atypical Argyll-Robertson Pupil Argyll Robertson Phenomenon Or Pupil, Nonsyphilitic Argyll Robertson Pupil, Atypical
Abnormal Pupillary Function
Pupil Disease	Pupil Disorders Pupillary Disorder
Diamond-Blackfan Anemia 5	DBA5 Rpl35a-Related Diamond-Blackfan Anemia Anemia, Diamond-Blackfan, Type 5
Retinitis Pigmentosa 7	Leber Congenital Amaurosis 18 RP7 Retinitis Pigmentosa 7, Digenic Form Retinitis Pigmentosa 7 And Digenic Form Retinitis Pigmentosa 7, Digenic LCA18 Retinitis Pigmentosa 7 Digenic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16055	ZFYVE1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ZFYVE1	VGNC	VGNC:78911
Mus musculus	ZFYVE1	MGD	MGI:3026685
Bos taurus	ZFYVE1	VGNC	VGNC:37173
Rattus norvegicus	ZFYVE1	RGD	RGD:1307795
Canis familiaris	ZFYVE1	VGNC	VGNC:48622
Felis catus	ZFYVE1	VGNC	VGNC:67237
Others	ZFYVE1	NCBI