Reck - reversion-inducing-cysteine-rich protein with kazal motifs Gene

Also Known as St15; mRECK

Species: Mus musculus

Gene Type: protein coding

Gene ID: 53614

Summary

Enables Wnt-protein binding activity; coreceptor activity involved in canonical Wnt signaling pathway; and endopeptidase inhibitor activity. Involved in several processes, including negative regulation of metalloendopeptidase activity; positive regulation of canonical Wnt signaling pathway; and regulation of establishment of blood-brain barrier. Acts upstream of or within several processes, including blood vessel maturation; embryo implantation; and embryonic forelimb morphogenesis. Located in plasma membrane. Part of Wnt signalosome. Is expressed in diaphragm; genitourinary system; and skeletal musculature. Orthologous to human RECK (reversion inducing cysteine rich protein with kazal motifs). [provided by Alliance of Genome Resources, Apr 2022]

Reck Products (1)

mRNA	Protein	Name
NM_016678.2	NP_057887.2	reversion-inducing cysteine-rich protein with Kazal motifs precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables Wnt-protein binding	IPI IPI: Inferred from physical interaction	30026314	MGI
enables coreceptor activity	IDA IDA: Inferred from direct assay	30026314	MGI
enables endopeptidase inhibitor activity	IDA IDA: Inferred from direct assay	11747814	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	30026314	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within blood vessel maturation	IGI IGI: Inferred from genetic interaction	11747814	MGI
acts upstream of or within blood vessel maturation	IMP IMP: Inferred from mutant phenotype	11747814	MGI
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	30026314	MGI
acts upstream of or within embryo implantation	IDA IDA: Inferred from direct assay	18556655	MGI
acts upstream of or within embryonic forelimb morphogenesis	IMP IMP: Inferred from mutant phenotype	23213437	MGI
acts upstream of or within extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	11747814	MGI
involved in negative regulation of metalloendopeptidase activity	IMP IMP: Inferred from mutant phenotype	24812324	MGI
involved in positive regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	28803732	MGI
involved in regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	28803732	MGI
involved in regulation of establishment of blood-brain barrier	IMP IMP: Inferred from mutant phenotype	28803732	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of Wnt signalosome	IDA IDA: Inferred from direct assay	30026314	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	28803732	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
reversion-inducing cysteine-rich protein with Kazal motifs	Reversion-inducing cysteine-rich protein with Kazal motifs precursor (mRECK) membrane-anchored glycoprotein RECK suppression of tumorigenicity 15

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11809	RECK Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-124068	LQB-118		/	Unkown
HY-RS19944	Reck Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26446	Reck Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Reck	NCBI	NCBI:8434