Irf7 - interferon regulatory factor 7 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 54123

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Involved in defense response to Other organism; positive regulation of transcription, DNA-templated; and regulation of Toll-like Receptor signaling pathway. Acts upstream of or within immunoglobulin mediated immune response; positive regulation of type I interferon production; and positive regulation of type I interferon-mediated signaling pathway. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in apical ectodermal ridge; embryo; liver; and ureter. Human ortholog(s) of this gene implicated in immunodeficiency 39. Orthologous to human IRF7 (interferon regulatory factor 7). [provided by Alliance of Genome Resources, Apr 2022]

Irf7 Products (3)

mRNA Protein Name
NM_001252600.1 NP_001239529.1 interferon regulatory factor 7 isoform 2
NM_001252601.1 NP_001239530.1 interferon regulatory factor 7 isoform 3
NM_016850.3 NP_058546.1 interferon regulatory factor 7 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
22095711 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
27129230 MGI
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
27129230 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16236719 MGI
Biological Process GO Annotation Evidence References Source
involved in defense response to virus IMP
IMP: Inferred from mutant phenotype
27129230 MGI
acts upstream of or within immunoglobulin mediated immune response IMP
IMP: Inferred from mutant phenotype
15800576 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
27129230 MGI
involved in positive regulation of type I interferon production IDA
IDA: Inferred from direct assay
22095711 MGI
acts upstream of or within positive regulation of type I interferon production IGI
IGI: Inferred from genetic interaction
23956435 MGI
acts upstream of or within positive regulation of type I interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
17618271 MGI
involved in regulation of MyD88-dependent toll-like receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15800576 MGI
involved in regulation of MyD88-independent toll-like receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15800576 MGI
acts upstream of or within regulation of gene expression IGI
IGI: Inferred from genetic interaction
23160154 MGI
acts upstream of or within type I interferon production IMP
IMP: Inferred from mutant phenotype
15800576 MGI
involved in type I interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
27129230 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interferon regulatory factor 7

  • IRF-7

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-176426 Subquinocin 99.83% Phase 4

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-146244 Agatolimod 98.84% Unkown
HY-150741C ODN 2216 sodium Agonist 98.57% Unkown
HY-150741 ODN 2216 98.57% Unkown
HY-160229 ssRNA40 sodium 98.34% Unkown
HY-P11072 IRF5-CPP5 Inhibitor 99.23% Unkown
HY-150750A ODN M362 sodium 97.02% Unkown
HY-117066 CL075 Agonist 99.18% Unkown
HY-122891 SB02024 99.70% Unkown
HY-RS06911 IRF7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-162465 BDW568 Agonist 99.4% Unkown
HY-RS16952 Irf7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-184488 AT-1965 Inhibitor / Unkown
HY-178690 MyD88-IN-4 Inhibitor / Unkown
HY-174663 Human IFNE mRNA / Unkown
HY-RS23395 Irf7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Irf7 NCBI NCBI:3665