Sstr2 - somatostatin receptor 2 Gene

Also Known as Smstr2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 54305

About Sstr2

Primary_assembly 10: 98,664,216-98,674,351 forward strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 264 orthologues, 14 paralogues and is associated with 7 phenotypes. Biased expression in Adrenal (RPKM 48.4), Brain (RPKM 31.2) and 3 other tissues.

Summary

Enables PDZ domain binding activity and Somatostatin Receptor activity. Involved in several processes, including brain development; cellular response to lipid; and peristalsis. Located in cytoplasm and plasma membrane. Orthologous to human SSTR2 (Somatostatin Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Sstr2 Products (1)

mRNA Protein Name
NM_019348.2 NP_062221.1 somatostatin receptor type 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
10551867 RGD
enables somatostatin receptor activity IDA
IDA: Inferred from direct assay
1374909 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to estradiol stimulus IEP
IEP: Inferred from expression pattern
9564833 RGD
involved in cellular response to glucocorticoid stimulus IEP
IEP: Inferred from expression pattern
14512709 RGD
involved in cerebellum development IEP
IEP: Inferred from expression pattern
9166718 RGD
involved in forebrain development IEP
IEP: Inferred from expression pattern
10805921 RGD
involved in peristalsis IMP
IMP: Inferred from mutant phenotype
12504886 RGD
involved in response to starvation IEP
IEP: Inferred from expression pattern
7956902 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
9421433 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sstr2 Protein Structure

7tmA_SSTR2

7tmA_SSTR2: cd15971 (43 - 322)

7tmA_SSTR2

7tmA_SSTR2: cd15971 (44 - 70)

7tmA_SSTR2

7tmA_SSTR2: cd15971 (77 - 103)

7tmA_SSTR2

7tmA_SSTR2: cd15971 (114 - 144)

7tmA_SSTR2

7tmA_SSTR2: cd15971 (156 - 178)

7tmA_SSTR2

7tmA_SSTR2: cd15971 (204 - 233)

7tmA_SSTR2

7tmA_SSTR2: cd15971 (248 - 278)

7tmA_SSTR2

7tmA_SSTR2: cd15971 (290 - 315)

  • 0
  • 100
  • 200
  • 300
  • 369 a.a.
Protein Preferred Names Protein Names

somatostatin receptor type 2

  • SRIF-1

  • SS-2-R

  • SS2-R

  • SS2R

  • somatostatin receptor subtype 2

  • somatotropin release-inhibiting factor receptor

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P0036 Octreotide Agonist 99.96% Unkown
HY-P0036B Octreotide pamoate Agonist / Unkown

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-P10137 Satoreotide Antagonist 98.80% Phase 2
HY-P5362 NODAGA-LM3 Antagonist 99.65% Phase 2
HY-P0024 Veldoreotide Activator / Phase 2
HY-106103 Seglitide Modulator 99.30% Phase 2
HY-P3294 Onzigolide Agonist / Phase 2

Pre-clinical Phase

Bioactive Molecules (22)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1932 Cortistatin-14 99.98% Unkown
HY-P1202 CYN 154806 Antagonist 99.96% Unkown
HY-P3124A BIM-23190 hydrochloride Agonist 99.33% Unkown
HY-P1202A CYN 154806 TFA Antagonist 98.30% Unkown
HY-P0024A Veldoreotide TFA Agonist 98.97% Unkown
HY-P4452 PRL 2915 Antagonist 99.92% Unkown
HY-P2090A Angiopeptin TFA Agonist 99.01% Unkown
HY-P3618 Cortistatin-29 (reduced) 98.12% Unkown
HY-P5362A NODAGA-LM3 TFA Antagonist / Unkown
HY-P4469 PRL 3195 Antagonist / Unkown
HY-P10239 Tyr3-Octreotate Ligand 99.76% Unkown
HY-P2545 [Tyr1]-Somatostatin-14 / Unkown
HY-P2150 Cortistatin-29 (rat) / Unkown
HY-P0042 BIM-23197 Agonist / Unkown
HY-P11485 JR11-PEG3-HBED-CC-PSMA-03 Antagonist / Unkown
HY-P11900 Ac-crown-TATE Agonist / Unkown
HY-P11488 JR11-PEG3-DOTA-PSMA-03 Ligand / Unkown
HY-P2434 AP102 / Unkown
HY-110161 sst2 Receptor agonist-1 Agonist / Unkown
HY-P3124 BIM-23190 Agonist / Unkown
HY-P2090 Angiopeptin Agonist / Unkown
HY-P11924 TATE-DA-I Ligand / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sstr2 NCBI NCBI:6752