INO80 - INO80 complex ATPase subunit Gene

Also Known as INOC1; INO80A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54617

About INO80

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:40,978,880-41,116,280 (from NCBI)

This gene has 17 transcripts (splice variants), 201 orthologues, 30 paralogues and is associated with 1 phenotype. Ubiquitous expression in bone marrow (RPKM 5.6), testis (RPKM 5.5) and 25 other tissues.

Summary

This gene encodes a subunit of the chromatin remodeling complex, which is classified into subfamilies depending on sequence features apart from the conserved ATPase domain. This protein is the catalytic ATPase subunit of the INO80 chromatin remodeling complex, which is characterized by a DNA-binding domain. This protein is proposed to bind DNA and be recruited by the YY1 transcription factor to activate certain genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

INO80 Products (1)

mRNA Protein Name
NM_017553.3 NP_060023.1 chromatin-remodeling ATPase INO80

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP-dependent activity, acting on DNA IDA
IDA: Inferred from direct assay
16298340 GOA
enables DNA binding IDA
IDA: Inferred from direct assay
16298340 GOA
enables alpha-tubulin binding IMP
IMP: Inferred from mutant phenotype
20237820 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18026119 GOA
Biological Process GO Annotation Evidence References Source
involved in UV-damage excision repair IMP
IMP: Inferred from mutant phenotype
20855601 GOA
involved in cellular response to UV IMP
IMP: Inferred from mutant phenotype
18026119 GOA
involved in cellular response to ionizing radiation IMP
IMP: Inferred from mutant phenotype
20687897 GOA
involved in chromatin remodeling IDA
IDA: Inferred from direct assay
21303910 GOA
involved in double-strand break repair IMP
IMP: Inferred from mutant phenotype
20687897 GOA
involved in double-strand break repair via homologous recombination IMP
IMP: Inferred from mutant phenotype
18026119 GOA
involved in mitotic sister chromatid segregation IMP
IMP: Inferred from mutant phenotype
20237820 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
27641337 GOA
involved in positive regulation of cell growth IMP
IMP: Inferred from mutant phenotype
20237820 GOA
involved in positive regulation of nuclear cell cycle DNA replication IMP
IMP: Inferred from mutant phenotype
20237820 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20687897 GOA
involved in regulation of DNA replication IMP
IMP: Inferred from mutant phenotype
25016522 GOA
involved in regulation of DNA strand elongation IMP
IMP: Inferred from mutant phenotype
25016522 GOA
involved in regulation of G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
20237820 GOA
involved in regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
26340092 GOA
involved in regulation of chromosome organization IMP
IMP: Inferred from mutant phenotype
26340092 GOA
involved in spindle assembly IMP
IMP: Inferred from mutant phenotype
20237820 GOA
Cellular Component GO Annotation Evidence References Source
part of Ino80 complex IDA
IDA: Inferred from direct assay
18026119 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16298340 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INO80 Protein Structure

DBINO

DBINO: DNA-binding domain (271 - 405)

SNF2_N

SNF2_N: SNF2 family N-terminal domain (521 - 822)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (1140 - 1214)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1556 a.a.
Protein Preferred Names Protein Names

chromatin-remodeling ATPase INO80

  • DNA helicase INO80

INO80 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
INO80 Q9ULG1 DDB1 Homo sapiens Q16531
Anti Bait CoIP
20855601
Intra
INO80 Q9ULG1 PLEKHF2 Homo sapiens Q9H8W4
Y2H Prey Pooling
32296183
Intra
INO80 Q9ULG1 PLEKHF2 Homo sapiens Q9H8W4
Y2H Array
32296183
Intra
INO80 Q9ULG1 YY1 Homo sapiens P25490
Anti Tag CoIP
33961781
Intra
INO80 Q9ULG1 ACTR5 Homo sapiens Q9H9F9
Anti Tag CoIP
33961781
Intra
INO80 Q9ULG1 ACTR5 Homo sapiens Q9H9F9
Anti Tag CoIP
35271311
Intra
INO80 Q9ULG1 ACTR5 Homo sapiens Q9H9F9
Anti Tag CoIP
19014934
Intra
INO80 Q9ULG1 ACTR5 Homo sapiens Q9H9F9
Anti Bait CoIP
20855601
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Combined Cellular And Humoral Immune Defects With Granulomas

  • Combined Immunodeficiency With Skin Granulomas

  • CCHIDG

  • Cid Due To Rag 1/2 Deficiency

  • Combined Immunodeficiency Due To Rag 1/2 Deficiency

  • Combined Immunodeficiency With Granulomatosis

  • CHIDG

  • Immune Defects, Combined Cellular And Humoral With Granulomas
Primary Microcephaly

  • True Microcephaly

  • Microcephaly, Primary
Grange Syndrome

  • Arterial Occlusive Disease, Progressive, With Hypertension, Heart Defects, Bone Fragility, And Brachysyndactyly

  • Grange Occlusive Arterial Syndrome

  • GRNG

  • Progressive Arterial Occlusive Disease-Hypertension-Heart Defects-Bone Fragility-Brachysyndactyly Syndrome
Fibromuscular Dysplasia
Floating-Harbor Syndrome

  • FLHS

  • Fhs

  • Pelletier-Leisti Syndrome

  • Short Stature With Delayed Bone Age, Expressive Language Delay, A Triangular Face With A Prominent Nose And Deep-Set Eyes

  • Leisti-Hollander-Rimoin Syndrome
Immunodeficiency 43

  • Hypoproteinemia, Hypercatabolic

  • IMD43

  • Beta-2-Microglobulin Deficiency

  • B2m Deficiency

  • Hypercatabolic Hypoproteinemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06821 INO80 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06822 INO80D Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06823 INO80E Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19697 Ino80 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26192 Ino80 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus INO80 VGNC VGNC:30205
Rattus norvegicus INO80 RGD RGD:1310969
Macaca mulatta INO80 VGNC VGNC:84358
Mus musculus INO80 MGD MGI:1915392
Felis catus INO80 VGNC VGNC:62926
Canis familiaris INO80 VGNC VGNC:42024
Others INO80 NCBI