PPA1 - inorganic pyrophosphatase 1 Gene

Also Known as PP; PP1; IOPPP; HEL-S-66p; SID6-8061

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5464

About PPA1

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:70,202,835-70,233,429 (from NCBI)

This gene has 6 transcripts (splice variants), 284 orthologues and 1 paralogue. Ubiquitous expression in adrenal (RPKM 81.3), colon (RPKM 70.8) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the inorganic pyrophosphatase (PPase) family. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Studies of a similar protein in bovine suggested a cytoplasmic localization of this enzyme. [provided by RefSeq, Jul 2008]

PPA1 Products (1)

mRNA Protein Name
NM_021129.4 NP_066952.1 inorganic pyrophosphatase

PPA1 Protein Structure

Pyrophosphatase

Pyrophosphatase: Inorganic pyrophosphatase (45 - 228)

  • 0
  • 100
  • 200
  • 289 a.a.
Protein Preferred Names Protein Names

inorganic pyrophosphatase

  • PPase

PPA1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82041 Pyrophosphatase 1 Antibody (YA1786) WB, FC, IP Human, Mouse, Rat
HY-P82041A Pyrophosphatase 1 Antibody (YA1786)(PBS only) WB, FC, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Baylisascariasis

  • Infection By Baylisascaris
Hypophosphatasia, Adult

  • Adult Hypophosphatasia

  • Odontohypophosphatasia

  • Hypophosphatasia, Mild

  • HPPA

  • Hypophosphatasia

  • Mild Hypophosphatasia

  • Adult Rathbun Disease

  • Adult Phosphoethanolaminuria

  • HOPS
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P4072A (D)-PPA 1 TFA Inhibitor 99.11% Unkown
HY-P4072 (D)-PPA 1 Inhibitor / Unkown
HY-RS10914 PPA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-23201 A1-Phytoprostane-I / Unkown
HY-RS20798 Ppa1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27312 Ppa1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PPA1 VGNC VGNC:55992
Macaca mulatta PPA1 VGNC VGNC:103845
Canis familiaris PPA1 VGNC VGNC:81244
Felis catus PPA1 VGNC VGNC:96709
Mus musculus PPA1 MGD MGI:97831
Rattus norvegicus PPA1 RGD RGD:1589773
Others PPA1 NCBI