2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. (D)-PPA 1 TFA

(D)-PPA 1 TFA is a hydrolysisresistant d-peptide antagonist. (D)-PPA 1 TFA serves as a potent PD-1/PD-L1 inhibitor. (D)-PPA 1 TFA binds to PD-1 with the affinity 0f 0.51 μM with in vitro and in vivo efficacy.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

(D)-PPA 1 TFA Chemical Structure

(D)-PPA 1 TFA Chemical Structure

Size Price Stock Quantity
1 mg USD 220 In-stock
5 mg USD 550 In-stock
10 mg USD 820 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of (D)-PPA 1 TFA:

(D)-PPA 1 TFA Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

(D)-PPA 1 TFA is a hydrolysisresistant d-peptide antagonist. (D)-PPA 1 TFA serves as a potent PD-1/PD-L1 inhibitor. (D)-PPA 1 TFA binds to PD-1 with the affinity 0f 0.51 μM with in vitro and in vivo efficacy[1].

In Vitro

(D)-PPA 1 TFA (0.2 mg/mL, 1.0 mg/mL) blocks the interaction between PD-1/PD-L1 at 1.0 mg/mL[1].
(D)-PPA 1 TFA (3.125-100 μM; 24 h, 48 h) doesn’t kill tumor cells directly with no affect on CT26 cells growth[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(D)-PPA 1 TFA Related Antibodies
In Vivo

(D)-PPA 1 TFA (2 mg/kg; s.c. or i.p.; once daily for 7 d) inhibits CT26 tumor growth in vivo in mice[1].
(D)-PPA 1 TFA (40 μg/mouse in 200 μL; i.v.; single dose) has the ability to target to tumor tissue in CT26-tumor-bearing mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

1669.67

Formula

C72H99F3N20O23
Appearance

Solid

Color

White to off-white

Sequence

D-{Asn-Tyr-Ser-Lys-Pro-Thr-Asp-Arg-Gln-Tyr-His-Phe}
Sequence Shortening

D-{NYSKPTDRQYHF}
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (59.89 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5989 mL 2.9946 mL 5.9892 mL
5 mM 0.1198 mL 0.5989 mL 1.1978 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.5989 mL 2.9946 mL 5.9892 mL 14.9730 mL
5 mM 0.1198 mL 0.5989 mL 1.1978 mL 2.9946 mL
10 mM 0.0599 mL 0.2995 mL 0.5989 mL 1.4973 mL
15 mM 0.0399 mL 0.1996 mL 0.3993 mL 0.9982 mL
20 mM 0.0299 mL 0.1497 mL 0.2995 mL 0.7487 mL
25 mM 0.0240 mL 0.1198 mL 0.2396 mL 0.5989 mL
30 mM 0.0200 mL 0.0998 mL 0.1996 mL 0.4991 mL
40 mM 0.0150 mL 0.0749 mL 0.1497 mL 0.3743 mL
50 mM 0.0120 mL 0.0599 mL 0.1198 mL 0.2995 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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(D)-PPA 1 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(D)-PPA 1PD-1/PD-L1PD-1/Programmed death-ligand 1Inhibitorinhibitorinhibit

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