NSMCE4A - NSE4A component of SMC5/6 complex Gene

Also Known as NS4EA; NSE4A; C10orf86

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54780

Summary

Involved in DNA damage response. Located in nucleoplasm. Part of Smc5-Smc6 complex. [provided by Alliance of Genome Resources, Jun 2026]
Ubiquitous expression in prostate (RPKM 10.0), fat (RPKM 9.2) and 25 other tissues.

NSMCE4A Products (3)

mRNA Protein Name
NM_001167865.2 NP_001161337.1 non-structural maintenance of chromosomes element 4 homolog A isoform 2
NM_001411073.1 NP_001398002.1 non-structural maintenance of chromosomes element 4 homolog A isoform 3
NM_017615.3 NP_060085.2 non-structural maintenance of chromosomes element 4 homolog A isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
20864041 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
18086888 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of Smc5-Smc6 complex IDA
IDA: Inferred from direct assay
18086888 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NSMCE4A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
NSMCE4A Q9NXX6 NSMCE3 Homo sapiens Q96MG7
Anti Tag CoIP
33961781
Intra
NSMCE4A Q9NXX6 NSMCE3 Homo sapiens Q96MG7
Y2H
27427983
Intra
NSMCE4A Q9NXX6 NSMCE3 Homo sapiens Q96MG7
Anti Tag CoIP
28514442
Intra
NSMCE4A Q9NXX6 NSMCE3 Homo sapiens Q96MG7
Anti Tag CoIP
21364888
Cross: Cross-species interaction Intra: Intraspecies interaction