CWC25 - CWC25 spliceosome associated protein homolog Gene

Also Known as CCDC49

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54883

About CWC25

This gene has 7 transcripts (splice variants), 1 gene allele and 212 orthologues. Ubiquitous expression in bone marrow (RPKM 26.7), testis (RPKM 10.6) and 24 other tissues.

Summary

This gene encodes a factor that is part of the multi-protein C complex involved in pre-mRNA splicing. Alternatively spliced transcripts have been described for this gene. [provided by RefSeq, Nov 2012]

CWC25 Products (1)

mRNA Protein Name
NM_017748.5 NP_060218.1 pre-mRNA-splicing factor CWC25 homolog

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
29301961 GOA
Cellular Component GO Annotation Evidence References Source
part of U2-type catalytic step 1 spliceosome IDA
IDA: Inferred from direct assay
29301961 GOA
located in nucleus IDA
IDA: Inferred from direct assay
29301961 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CWC25 Protein Structure

Cir_N

Cir_N: N-terminal domain of CBF1 interacting co-repressor CIR (11 - 47)

CWC25

CWC25: Pre-mRNA splicing factor (64 - 157)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 425 a.a.
Protein Preferred Names Protein Names

pre-mRNA-splicing factor CWC25 homolog

  • coiled-coil domain-containing protein 49

CWC25 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CWC25 Q9NXE8 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
CWC25 Q9NXE8 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
CWC25 Q9NXE8 FMR1 Homo sapiens Q8IXW7
Y2H Prey Pooling
32296183
Intra
CWC25 Q9NXE8 FMR1 Homo sapiens Q8IXW7
Y2H Array
32296183
Intra
CWC25 Q9NXE8 TRIM21 Homo sapiens P19474
Y2H Prey Pooling
32296183
Intra
CWC25 Q9NXE8 TRIM21 Homo sapiens P19474
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03374 CWC25 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CWC25 VGNC VGNC:71582
Felis catus CWC25 VGNC VGNC:61292
Canis familiaris CWC25 VGNC VGNC:39742
Bos taurus CWC25 VGNC VGNC:27842
Mus musculus CWC25 MGD MGI:1914730
Rattus norvegicus CWC25 RGD RGD:1305258
Others CWC25 NCBI