COMMD8 - COMM domain containing 8 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54951

Summary

The protein encoded by this gene binds coiled-coil domain-containing protein 22 (CCDC22), and this complex can regulate the turnover of I-kappa-B and the activation of NF-kappa-B. [provided by RefSeq, Jul 2016]
Ubiquitous expression in kidney (RPKM 8.5), testis (RPKM 8.1) and 25 other tissues.

COMMD8 Products (2)

mRNA Protein Name
NM_001329668.2 NP_001316597.1 COMM domain-containing protein 8 isoform 2
NM_017845.5 NP_060315.1 COMM domain-containing protein 8 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15799966 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COMMD8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
COMMD8 Q9NX08 CCDC93 Homo sapiens Q567U6
Anti Tag CoIP
33961781
Intra
COMMD8 Q9NX08 CCDC93 Homo sapiens Q567U6
Anti Tag CoIP
28514442
Intra
COMMD8 Q9NX08 CCDC93 Homo sapiens Q567U6
Pull Down
25355947
Intra
COMMD8 Q9NX08 COMMD4 Homo sapiens Q9H0A8
Y2H Prey Pooling
32296183
Intra
COMMD8 Q9NX08 COMMD4 Homo sapiens Q9H0A8
Anti Tag CoIP
37172566
Intra
COMMD8 Q9NX08 COMMD4 Homo sapiens Q9H0A8
Anti Tag CoIP
28514442
Intra
COMMD8 Q9NX08 COMMD4 Homo sapiens Q9H0A8
Y2H Array
32296183
Intra
COMMD8 Q9NX08 COMMD4 Homo sapiens Q9H0A8
Anti Tag CoIP
33961781
Intra
COMMD8 Q9NX08 COMMD1 Homo sapiens Q8N668
Anti Tag CoIP
37172566
Intra
COMMD8 Q9NX08 COMMD1 Homo sapiens Q8N668
Anti Tag CoIP
33961781
Intra
COMMD8 Q9NX08 COMMD1 Homo sapiens Q8N668
Pull Down
23563313
Intra
COMMD8 Q9NX08 ZNF474 Homo sapiens Q6S9Z5
Y2H Array
32296183
Intra
COMMD8 Q9NX08 ZNF474 Homo sapiens Q6S9Z5
Y2H Prey Pooling
32296183
Intra
COMMD8 Q9NX08 CCDC22 Homo sapiens O60826
Anti Tag CoIP
33961781
Intra
COMMD8 Q9NX08 CCDC22 Homo sapiens O60826
Anti Tag CoIP
28514442
Intra
COMMD8 Q9NX08 COMMD3 Homo sapiens Q9UBI1
Anti Tag CoIP
33961781
Intra
COMMD8 Q9NX08 COMMD3 Homo sapiens Q9UBI1
Anti Tag CoIP
28514442
Intra
COMMD8 Q9NX08 COMMD3 Homo sapiens Q9UBI1
Anti Tag CoIP
37172566
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant COMMD8 Proteins

Cat. No. Product Name Accession Purity
HY-P78555 COMMD8 Protein, Human (N-His) AAH19826 (M1-K183) ≥ 90%, as determined by reducing SDS-PAGE.