PPP1R10 - protein phosphatase 1 regulatory subunit 10 Gene

Also Known as p99; FB19; R111; CAT53; PNUTS; PP1R10

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5514

About PPP1R10

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:30,600,413-30,617,243 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 196 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 17.1), adrenal (RPKM 16.4) and 25 other tissues.

Summary

This gene encodes a protein Phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and Apoptosis by regulating the activity of protein Phosphatase 1. This gene lies within the major histocompatibility complex class I region on chromosome 6, and alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

PPP1R10 Products (2)

mRNA	Protein	Name
NM_001376195.1	NP_001363124.1	serine/threonine-protein phosphatase 1 regulatory subunit 10
NM_002714.4	NP_002705.2	serine/threonine-protein phosphatase 1 regulatory subunit 10

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15231748	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of cardiac muscle cell apoptotic process	IDA IDA: Inferred from direct assay	23426265	GOA
involved in negative regulation of mitotic DNA damage checkpoint	IGI IGI: Inferred from genetic interaction	23426265	GOA
involved in positive regulation of telomere maintenance	IMP IMP: Inferred from mutant phenotype	23426265	GOA

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with chromosome, telomeric region	IDA IDA: Inferred from direct assay	24270157	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP1R10 Protein Structure

Med26

zf-CCCH

0
200
400
600
800
940 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein phosphatase 1 regulatory subunit 10	HLA-C associated transcript 53

PPP1R10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PPP1R10	Q96QC0	PPP1CA	Homo sapiens	P62136	Y2H	15231748

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Adrenal Gland Pheochromocytoma	Pheochromocytoma
Hypermethioninemia Due To Adenosine Kinase Deficiency	Adk Hypermethioninemia Hypermethioninemia Encephalopathy Due To Adenosine Kinase Deficiency Hypermethioninemia Encephalopathy Due To Adk Deficiency Mrt8 Mental Retardation, Autosomal Recessive 8, Formerly Mrt8, Formerly HMAKD Mental Retardation, Autosomal Recessive 8

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10976	PPP1R10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PPP1R10	VGNC	VGNC:33221
Rattus norvegicus	PPP1R10	RGD	RGD:620079
Mus musculus	PPP1R10	MGD	MGI:1289273
Canis familiaris	PPP1R10	VGNC	VGNC:44876
Macaca mulatta	PPP1R10	VGNC	VGNC:76367
Felis catus	PPP1R10	VGNC	VGNC:68999
Others	PPP1R10	NCBI