HAUS2 - HAUS augmin like complex subunit 2 Gene

Also Known as CEP27; C15orf25; HsT17025

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55142

About HAUS2

Cytogenetic location: 15q15.2 Genomic coordinates (GRCh38): 15:42,548,838-42,569,994 (from NCBI)

This gene has 10 transcripts (splice variants) and 185 orthologues. Ubiquitous expression in bone marrow (RPKM 7.1), brain (RPKM 3.8) and 25 other tissues.

Summary

The protein encoded by this gene is a subunit of the augmin complex. The augmin complex plays a role in microtubule attachment to the kinetochore and central spindle formation. [provided by RefSeq, Apr 2016]

HAUS2 Products (6)

mRNA Protein Name
NM_001130447.2 NP_001123919.1 HAUS augmin-like complex subunit 2 isoform 2
NM_001323629.2 NP_001310558.1 HAUS augmin-like complex subunit 2 isoform 3
NM_001323630.2 NP_001310559.1 HAUS augmin-like complex subunit 2 isoform 4
NM_001323631.2 NP_001310560.1 HAUS augmin-like complex subunit 2 isoform 5
NM_001323632.2 NP_001310561.1 HAUS augmin-like complex subunit 2 isoform 5
NM_018097.3 NP_060567.1 HAUS augmin-like complex subunit 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19369198 GOA
Biological Process GO Annotation Evidence References Source
involved in centrosome cycle IMP
IMP: Inferred from mutant phenotype
19427217 GOA
involved in spindle assembly IMP
IMP: Inferred from mutant phenotype
19369198 GOA
Cellular Component GO Annotation Evidence References Source
part of HAUS complex IDA
IDA: Inferred from direct assay
19369198 GOA
part of HAUS complex IPI
IPI: Inferred from physical interaction
20360068 GOA
located in centrosome IDA
IDA: Inferred from direct assay
14654843 GOA
located in mitotic spindle microtubule IDA
IDA: Inferred from direct assay
30723163 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HAUS2 Protein Structure

HAUS2

HAUS2: HAUS augmin-like complex subunit 2 (4 - 213)

  • 0
  • 100
  • 200
  • 235 a.a.
Protein Preferred Names Protein Names

HAUS augmin-like complex subunit 2

  • centrosomal protein 27kDa

HAUS2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HAUS2 Q9NVX0 HAUS6 Homo sapiens Q7Z4H7
DLS
25173975
Intra
HAUS2 Q9NVX0 HAUS6 Homo sapiens Q7Z4H7
TEM
25173975
Intra
HAUS2 Q9NVX0 HAUS6 Homo sapiens Q7Z4H7
TAP
24981860
Intra
HAUS2 Q9NVX0 HAUS6 Homo sapiens Q7Z4H7
Anti Tag CoIP
26496610
Intra
HAUS2 Q9NVX0 HAUS6 Homo sapiens Q7Z4H7
TAP
20360068
Intra
HAUS2 Q9NVX0 HAUS6 Homo sapiens Q7Z4H7
GMS
25173975
Intra
HAUS2 Q9NVX0 HAUS6 Homo sapiens Q7Z4H7
SLS
25173975
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Patella, Chondromalacia Of

  • Chondromalacia Patellae

  • Chondromalacia Of Patella

  • Softening Of Articular Cartilage Of Patella

  • Patellofemoral Pain Syndrome

  • Patellofemoral Chondromalacia
Meckel Syndrome, Type 8

  • Meckel Syndrome 8

  • MKS8

  • Meckel-Gruber Syndrome, Type 8
Laryngeal Benign Neoplasm

  • Laryngeal Tumor

  • Larynx Neoplasm

  • Neoplasm Of Larynx

  • Laryngeal Cancer

  • Laryngeal Carcinoma

  • Cancer Of Larynx
Glycerol Kinase Deficiency

  • Hyperglycerolemia

  • GKD

  • Gk Deficiency

  • Gk1 Deficiency

  • Deficiency Of Glycerol Kinase

  • Isolated Glycerol Kinase Deficiency

  • Glycerol Kinase Deficiency, Adult Form

  • Glycerol Kinase Deficiency, Juvenile Form

  • Deficiency, Glycerol Kinase
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06014 HAUS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus HAUS2 VGNC VGNC:29758
Canis familiaris HAUS2 VGNC VGNC:41603
Felis catus HAUS2 VGNC VGNC:80958
Mus musculus HAUS2 MGD MGI:1913546
Rattus norvegicus HAUS2 RGD RGD:9250626
Macaca mulatta HAUS2 VGNC VGNC:73231
Others HAUS2 NCBI