DNAAF2 - dynein axonemal assembly factor 2 Gene

Also Known as KTU; PF13; CILD10; C14orf104

Species: Homo sapiens (human)

Gene Type: protein coding
Gene ID: 55172

Summary

This gene encodes a highly conserved protein involved in the preassembly of dynein arm complexes which power cilia. These complexes are found in some cilia and are assembled in the cytoplasm prior to transport for cilia formation. Mutations in this gene have been associated with primary ciliary dyskinesia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

DNAAF2 Products (1)

mRNA Protein Name
NM_018139.3 NP_060609.2 protein kintoun isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23872636 GOA
Biological Process GO Annotation Evidence References Source
involved in axonemal dynein complex assembly IMP
IMP: Inferred from mutant phenotype
19052621 GOA
involved in cilium-dependent cell motility IMP
IMP: Inferred from mutant phenotype
19052621 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19052621 GOA
part of protein folding chaperone complex IPI
IPI: Inferred from physical interaction
29844425 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein kintoun

  • dynein assembly factor 2, axonemal

  • kintoun

DNAAF2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DNAAF2 Q9NVR5 UBE3D Homo sapiens Q7Z6J8
TAP
27173435
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03839 DNAAF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03840 DNAAF3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03841 DNAAF5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown