2. Gene
  3. PBRM1 - polybromo 1 Gene

PBRM1 - polybromo 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
Homo sapiens

Also known as PB1; RCC; BAF180; SMARCH1

Gene ID: 55193 | Gene type: protein coding

About PBRM1

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:52,545,367-52,685,913 (from NCBI)

This gene has 20 transcripts (splice variants), 222 orthologues and is associated with 130 phenotypes. Ubiquitous expression in thyroid (RPKM 10.3), ovary (RPKM 8.8) and 25 other tissues.

Summary

This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma. [provided by RefSeq, Feb 2012]

PBRM1 Products(136)

mRNA Protein Name
NM_001350074.2 NP_001337003.1 protein polybromo-1 isoform 5
NM_001350075.2 NP_001337004.1 protein polybromo-1 isoform 6
NM_001350076.2 NP_001337005.1 protein polybromo-1 isoform 7
NM_001350077.2 NP_001337006.1 protein polybromo-1 isoform 8
NM_001350078.2 NP_001337007.1 protein polybromo-1 isoform 5
NM_001350079.2 NP_001337008.1 protein polybromo-1 isoform 9
NM_001366070.2 NP_001352999.1 protein polybromo-1 isoform 5
NM_001366071.2 NP_001353000.1 protein polybromo-1 isoform 10
NM_001366072.2 NP_001353001.1 protein polybromo-1 isoform 11
NM_001366073.2 NP_001353002.1 protein polybromo-1 isoform 12
NM_001366074.2 NP_001353003.1 protein polybromo-1 isoform 13
NM_001366075.2 NP_001353004.1 protein polybromo-1 isoform 14
NM_001366076.2 NP_001353005.1 protein polybromo-1 isoform 15
NM_001394867.1 NP_001381796.1 protein polybromo-1 isoform 16
NM_001394868.1 NP_001381797.1 protein polybromo-1 isoform 16
NM_001394869.1 NP_001381798.1 protein polybromo-1 isoform 16
NM_001394870.1 NP_001381799.1 protein polybromo-1 isoform 17
NM_001394871.1 NP_001381800.1 protein polybromo-1 isoform 18
NM_001394872.1 NP_001381801.1 protein polybromo-1 isoform 6
NM_001394873.1 NP_001381802.1 protein polybromo-1 isoform 20
NM_001394874.1 NP_001381803.1 protein polybromo-1 isoform 20
NM_001394875.1 NP_001381804.1 protein polybromo-1 isoform 4
NM_001394876.1 NP_001381805.1 protein polybromo-1 isoform 22
NM_001394877.1 NP_001381806.1 protein polybromo-1 isoform 22
NM_001394878.1 NP_001381807.1 protein polybromo-1 isoform 23
NM_001394879.1 NP_001381808.1 protein polybromo-1 isoform 24
NM_001394880.1 NP_001381809.1 protein polybromo-1 isoform 25
NM_001394881.1 NP_001381810.1 protein polybromo-1 isoform 26
NM_001400470.1 NP_001387399.1 protein polybromo-1 isoform 16
NM_001400471.1 NP_001387400.1 protein polybromo-1 isoform 27
NM_001400472.1 NP_001387401.1 protein polybromo-1 isoform 28
NM_001400473.1 NP_001387402.1 protein polybromo-1 isoform 29
NM_001400474.1 NP_001387403.1 protein polybromo-1 isoform 6
NM_001400475.1 NP_001387404.1 protein polybromo-1 isoform 6
NM_001400479.1 NP_001387408.1 protein polybromo-1 isoform 6
NM_001400481.1 NP_001387410.1 protein polybromo-1 isoform 20
NM_001400484.1 NP_001387413.1 protein polybromo-1 isoform 21
NM_001400487.1 NP_001387416.1 protein polybromo-1 isoform 30
NM_001400490.1 NP_001387419.1 protein polybromo-1 isoform 31
NM_001400496.1 NP_001387425.1 protein polybromo-1 isoform 4
NM_001400500.1 NP_001387429.1 protein polybromo-1 isoform 4
NM_001400501.1 NP_001387430.1 protein polybromo-1 isoform 4
NM_001400504.1 NP_001387433.1 protein polybromo-1 isoform 31
NM_001405552.1 NP_001392481.1 protein polybromo-1 isoform 52
NM_001405553.1 NP_001392482.1 protein polybromo-1 isoform 55
NM_001405554.1 NP_001392483.1 protein polybromo-1 isoform 53
NM_001405555.1 NP_001392484.1 protein polybromo-1 isoform 4
NM_001405556.1 NP_001392485.1 protein polybromo-1 isoform 6
NM_001405557.1 NP_001392486.1 protein polybromo-1 isoform 6
NM_001405558.1 NP_001392487.1 protein polybromo-1 isoform 21
NM_001405559.1 NP_001392488.1 protein polybromo-1 isoform 54
NM_001405560.1 NP_001392489.1 protein polybromo-1 isoform 71
NM_001405561.1 NP_001392490.1 protein polybromo-1 isoform 20
NM_001405563.1 NP_001392492.1 protein polybromo-1 isoform 22
NM_001405564.1 NP_001392493.1 protein polybromo-1 isoform 64
NM_001405565.1 NP_001392494.1 protein polybromo-1 isoform 21
NM_001405566.1 NP_001392495.1 protein polybromo-1 isoform 78
NM_001405567.1 NP_001392496.1 protein polybromo-1 isoform 51
NM_001405568.1 NP_001392497.1 protein polybromo-1 isoform 58
NM_001405569.1 NP_001392498.1 protein polybromo-1 isoform 59
NM_001405570.1 NP_001392499.1 protein polybromo-1 isoform 50
NM_001405571.1 NP_001392500.1 protein polybromo-1 isoform 57
NM_001405572.1 NP_001392501.1 protein polybromo-1 isoform 67
NM_001405573.1 NP_001392502.1 protein polybromo-1 isoform 68
NM_001405574.1 NP_001392503.1 protein polybromo-1 isoform 56
NM_001405575.1 NP_001392504.1 protein polybromo-1 isoform 20
NM_001405576.1 NP_001392505.1 protein polybromo-1 isoform 70
NM_001405577.1 NP_001392506.1 protein polybromo-1 isoform 4
NM_001405578.1 NP_001392507.1 protein polybromo-1 isoform 20
NM_001405579.1 NP_001392508.1 protein polybromo-1 isoform 29
NM_001405580.1 NP_001392509.1 protein polybromo-1 isoform 69
NM_001405581.1 NP_001392510.1 protein polybromo-1 isoform 16
NM_001405582.1 NP_001392511.1 protein polybromo-1 isoform 30
NM_001405583.1 NP_001392512.1 protein polybromo-1 isoform 18
NM_001405584.1 NP_001392513.1 protein polybromo-1 isoform 18
NM_001405585.1 NP_001392514.1 protein polybromo-1 isoform 20
NM_001405586.1 NP_001392515.1 protein polybromo-1 isoform 83
NM_001405587.1 NP_001392516.1 protein polybromo-1 isoform 65
NM_001405588.1 NP_001392517.1 protein polybromo-1 isoform 54
NM_001405589.1 NP_001392518.1 protein polybromo-1 isoform 51
NM_001405590.1 NP_001392519.1 protein polybromo-1 isoform 20
NM_001405591.1 NP_001392520.1 protein polybromo-1 isoform 61
NM_001405592.1 NP_001392521.1 protein polybromo-1 isoform 31
NM_001405593.1 NP_001392522.1 protein polybromo-1 isoform 4
NM_001405594.1 NP_001392523.1 protein polybromo-1 isoform 16
NM_001405595.1 NP_001392524.1 protein polybromo-1 isoform 62
NM_001405596.1 NP_001392525.1 protein polybromo-1 isoform 77
NM_001405597.1 NP_001392526.1 protein polybromo-1 isoform 63
NM_001405598.1 NP_001392527.1 protein polybromo-1 isoform 49
NM_001405599.1 NP_001392528.1 protein polybromo-1 isoform 30
NM_001405600.1 NP_001392529.1 protein polybromo-1 isoform 17
NM_001405601.1 NP_001392530.1 protein polybromo-1 isoform 48
NM_001405602.1 NP_001392531.1 protein polybromo-1 isoform 84
NM_001405603.1 NP_001392532.1 protein polybromo-1 isoform 16
NM_001405604.1 NP_001392533.1 protein polybromo-1 isoform 54
NM_001405605.1 NP_001392534.1 protein polybromo-1 isoform 31
NM_001405606.1 NP_001392535.1 protein polybromo-1 isoform 30
NM_001405607.1 NP_001392536.1 protein polybromo-1 isoform 48
NM_001405608.1 NP_001392537.1 protein polybromo-1 isoform 74
NM_001405609.1 NP_001392538.1 protein polybromo-1 isoform 66
NM_001405610.1 NP_001392539.1 protein polybromo-1 isoform 72
NM_001405611.1 NP_001392540.1 protein polybromo-1 isoform 73
NM_001405612.1 NP_001392541.1 protein polybromo-1 isoform 76
NM_001405613.1 NP_001392542.1 protein polybromo-1 isoform 80
NM_001405614.1 NP_001392543.1 protein polybromo-1 isoform 26
NM_001405615.1 NP_001392544.1 protein polybromo-1 isoform 26
NM_001405616.1 NP_001392545.1 protein polybromo-1 isoform 26
NM_001405617.1 NP_001392546.1 protein polybromo-1 isoform 81
NM_001405618.1 NP_001392547.1 protein polybromo-1 isoform 81
NM_001405619.1 NP_001392548.1 protein polybromo-1 isoform 79
NM_001405620.1 NP_001392549.1 protein polybromo-1 isoform 81
NM_001405621.1 NP_001392550.1 protein polybromo-1 isoform 79
NM_001405622.1 NP_001392551.1 protein polybromo-1 isoform 55
NM_001405623.1 NP_001392552.1 protein polybromo-1 isoform 6
NM_001405624.1 NP_001392553.1 protein polybromo-1 isoform 22
NM_001405625.1 NP_001392554.1 protein polybromo-1 isoform 75
NM_001405626.1 NP_001392555.1 protein polybromo-1 isoform 4
NM_001405627.1 NP_001392556.1 protein polybromo-1 isoform 4
NM_001405628.1 NP_001392557.1 protein polybromo-1 isoform 6
NM_001405629.1 NP_001392558.1 protein polybromo-1 isoform 51
NM_001405630.1 NP_001392559.1 protein polybromo-1 isoform 6
NM_001405631.1 NP_001392560.1 protein polybromo-1 isoform 6
NM_001405632.1 NP_001392561.1 protein polybromo-1 isoform 20
NM_001405633.1 NP_001392562.1 protein polybromo-1 isoform 21
NM_001405634.1 NP_001392563.1 protein polybromo-1 isoform 31
NM_001405635.1 NP_001392564.1 protein polybromo-1 isoform 21
NM_001405636.1 NP_001392565.1 protein polybromo-1 isoform 64
NM_001405637.1 NP_001392566.1 protein polybromo-1 isoform 60
NM_001405638.1 NP_001392567.1 protein polybromo-1 isoform 30
NM_001405639.1 NP_001392568.1 protein polybromo-1 isoform 82
NM_001405640.1 NP_001392569.1 protein polybromo-1 isoform 4
NM_001405641.1 NP_001392570.1 protein polybromo-1 isoform 18
NM_001405642.1 NP_001392571.1 protein polybromo-1 isoform 71
NM_001405643.1 NP_001392572.1 protein polybromo-1 isoform 18
NM_018313.5 NP_060783.3 protein polybromo-1 isoform 2
NM_181042.5 NP_851385.1 protein polybromo-1 isoform 4

PBRM1 Protein Structure

Bromodomain

Bromodomain: Bromodomain (65 - 137)

Bromodomain

Bromodomain: Bromodomain (198 - 274)

Bromodomain

Bromodomain: Bromodomain (400 - 472)

Bromodomain

Bromodomain: Bromodomain (541 - 612)

Bromodomain

Bromodomain: Bromodomain (676 - 749)

Bromodomain

Bromodomain: Bromodomain (804 - 866)

BAH

BAH: BAH domain (989 - 1049)

BAH

BAH: BAH domain (1133 - 1247)

HMG_box

HMG_box: HMG (high mobility group) box (1330 - 1379)

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  • 1582 a.a.
Protein Preferred Names Protein Names

protein polybromo-1

BRG1-associated factor 180

Recombinant PBRM1 Proteins

Cat. No. Product Name Accession Purity
HY-P7983 PB1 Protein, Human (His) Q86U86 ≥95%

Related Diseases

Diseases Alias
Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal Carcinoma, Chromophobe, Somatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell Carcinoma, Somatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

Carcinoma, Renal Cell

Renal Cell Carcinoma, Clear Cell, Somatic

Renal Cell Carcinoma, Clear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

Carcinoma, Renal Cell, Nonpapillary
Clear Cell Papillary Renal Cell Carcinoma
Collecting Duct Carcinoma

Kidney Medullary Carcinoma

Renal Medullary Carcinoma

Bdc

Bellini Carcinoma

Bellini Duct Carcinoma

Cdc

Collecting Duct Carcinoma Of The Kidney

Renal Cell Adenocarcinoma

Carcinoma Of Renal Collecting Duct

Renal Carcinoma, Collecting Duct Type

Renal Cell Carcinoma

Bellini'S Duct Carcinoma

Renal Collecting Duct Carcinoma

Adenocarcinoma Of Kidney
Papillary Carcinoma

Carcinoma, Papillary

Carcinoma Papillary
Chromophobe Renal Cell Carcinoma

Chromophobe Adenocarcinoma

Chromophobe Carcinoma Of Kidney

Kidney Chromophobe

Renal Cell Carcinoma, Chromophobe Cell

Crcc

Chrcc

Chromophobe Renal Cell Adenocarcinoma

Chromophobe Renal Carcinoma

Chromophobe Carcinoma
Uterine Corpus Endometrial Carcinoma
Cholangiocarcinoma

Cholangiocarcinoma, Susceptibility To

Extrahepatic Cholangiocarcinoma

Intrahepatic Cholangiocarcinoma

Chlc

Chlc, Susceptibility To

Cc

Cholangiocarcinoma Of Biliary Tract

Cholangiocellular Carcinoma

Distal Cholangiocarcinoma

Perihilar Cholangiocarcinoma

Bile Duct Cancer

Cca

Adult Primary Cholangiocellular Carcinoma

Bile Duct Carcinoma
Deafness, Autosomal Recessive 51

DFNB51

Autosomal Recessive Nonsyndromic Deafness 51

Autosomal Recessive Deafness 51
Chordoma

CHDM

Notochordoma

Notochordal Sarcoma

Chordoma, Susceptibility To

Chordocarcinoma

Chordoepithelioma
Sarcomatoid Renal Cell Carcinoma

Renal Cell Carcinoma, Spindle Cell
Trichothiodystrophy 4, Nonphotosensitive

Amish Brittle Hair Brain Syndrome

TTD4

Trichothiodystrophy, Nonphotosensitive 1

Hair-Brain Syndrome

Bids Syndrome

Ttdn1

Abhs

Pollitt Syndrome

Trichothiodystrophy-Neurocutaneous Syndrome

Nonphotosensitive Trichothiodystrophy 4

Trichorrhexis Nodosa Syndrome

Trichothiodystrophy 4, Non-Photosensitive

Trichothiodystrophy Non-Photosensitive 1
Ovarian Clear Cell Carcinoma

Clear-Cell Ovarian Carcinoma
Chromophil Adenoma Of The Kidney

Papillary Adenoma Of The Kidney
Rhabdoid Cancer

Rhabdoid Tumor

Malignant Rhabdoid Tumor

Malignant Rhabdoid Tumour

Rhabdoid Sarcoma

Rhabdoid Tumor Predisposition Syndrome 1

Rhabdoid Tumor Predisposition Syndrome 2

Atypical Teratoid Rhabdoid Tumor

Brain Tumor, Posterior Fossa, Of Infancy, Familial

Atypical Teratoid/Rhabdoid Tumor
Ovarian Small Cell Carcinoma

Small Cell Carcinoma Of The Ovary

Scco

Small Cell Ovarian Carcinoma
Clear Cell Adenofibroma

Cystadenofibroma
Clear Cell Meningioma
Renal Pelvis Carcinoma

Malignant Neoplasm Of Renal Pelvis

Malignant Tumor Of Renal Pelvis

Carcinoma Of Kidney Pelvis

Malignant Renal Pelvis Neoplasm

Renal Pelvis Cancer
Hereditary Renal Cell Carcinoma
Spinal Meningioma

Spinal Cord Meningioma

Meningioma, Spine

Meningioma

Meningioma, Benign, No Icd-O Subtype
Spinal Canal And Spinal Cord Meningioma
Intrahepatic Cholangiocarcinoma

Cholangiocarcinoma

Intrahepatic Bile Duct Carcinoma

Peripheral Cholangiocarcinoma

Peripheral Intrahepatic Cholangiocarcinoma

Adenocarcinoma Of Intra-Hepatic Bile Ducts

Cholangiocarcinoma, Unspecified Site

Cholangiocarcinoma Of Liver
Renal Cell Carcinoma, Papillary, 1

Papillary Renal Cell Carcinoma

Hereditary Papillary Renal Cell Carcinoma

Papillary Renal Cell Carcinoma, Sporadic

Papillary Renal Cell Adenocarcinoma

RCCP

RCCP1

Renal Cell Carcinoma, Papillary

Renal Cell Carcinoma, Papillary, 1, Familial And Somatic

Chromophil Carcinoma Of Kidney

Papillary Kidney Carcinoma

Sporadic Papillary Renal Cell Carcinoma

Chromophil Renal Cell Carcinoma

Papillary Renal Carcinoma, Malignant -

Papillary Renal Cell Carcinoma, Bilateral -

Papillary Renal Cell Carcinoma, Familial -

Papillary Renal Cell Carcinoma, Multiple -

Papillary Renal Cell Carcinoma, Sporadic -

Renal Adenocarcinoma

Chromophil Rcc

Hprcc

Renal Cell Carcinoma Papillary

Chromophilic Renal Cell Carcinoma

Prcc

Carcinoma, Renal Cell, Papillary, Type 1

Type 1 Papillary Renal Cell Carcinoma

Renal Cell Carcinoma

Hereditary Papillary Renal Carcinoma
Neurilemmomatosis

Schwannomatosis

Neurofibromatosis Type 3

Nf3

Neurilemmomatosis Congenital Cutaneous

Neurinomatosis

Congenital Cutaneous Neurilemmomatosis

Multiple Neurilemmomas

Multiple Schwannomas

Neurilemmomatosis, Congenital Cutaneous

Schwannomatosis 1

Neurofibromatosis 3

Mixed Central And Peripheral Neurofibromatosis

Nf3 - [Neurofibromatosis Type 3]
Melanoma, Uveal

Uveal Melanoma

Choroidal Melanoma

Melanoma Of Uvea

Iris Melanoma

Malignant Melanoma Of Choroid

Malignant Melanoma Of Iris
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-128359 ACBI1 98.83% Unkown
HY-149026 GNE-064 Inhibitor 99.75% Unkown
HY-151532 PBRM1-BD2-IN-5 Inhibitor 99.55% Unkown
HY-151538 PBRM1-BD2-IN-8 Inhibitor 99.48% Unkown
HY-150289 GNE-235 98.45% Unkown
HY-163410 AU-24118 Degrader / Unkown
HY-151528 PBRM1-BD2-IN-1 Inhibitor / Unkown
HY-151529 PBRM1-BD2-IN-2 Inhibitor / Unkown
HY-151530 PBRM1-BD2-IN-3 Inhibitor / Unkown
HY-151531 PBRM1-BD2-IN-4 Inhibitor / Unkown
HY-151533 PBRM1-BD2-IN-6 Inhibitor / Unkown
HY-151534 PBRM1-BD2-IN-7 Inhibitor / Unkown
HY-RS10105 PBRM1 Human Pre-designed siRNA Set A / Unkown