KLHDC8A - kelch domain containing 8A Gene

Homo sapiens

Gene ID: 55220 | Gene type: protein coding

About KLHDC8A

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:205,336,061-205,357,039 (from NCBI)

This gene has 12 transcripts (splice variants), 126 orthologues and 54 paralogues. Biased expression in ovary (RPKM 76.6) and adrenal (RPKM 7.3).

Summary

This gene encodes a kelch domain-containing protein which is upregulated in Cancer. Upregulated expression of the encoded protein may provide an alternative pathway for tumors to maintain aggressiveness in the absence of epidermal growth factor receptor dependence. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

KLHDC8A Products(4)

mRNA	Protein	Name
NM_001271863.2	NP_001258792.1	kelch domain-containing protein 8A
NM_001271864.2	NP_001258793.1	kelch domain-containing protein 8A
NM_001271865.2	NP_001258794.1	kelch domain-containing protein 8A
NM_018203.3	NP_060673.1	kelch domain-containing protein 8A

KLHDC8A Protein Structure

Kelch_1

Kelch_6

0
100
200
300
350 a.a.

Protein Preferred Names

Protein Names

kelch domain-containing protein 8A

S-delta-E1

Related Diseases

Diseases

Alias

Astrocytoma, Idh-Mutant, Grade 4

Idh-Mutant Glioblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07352	KLHDC8A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KLHDC8A	MGD	MGI:2442630
Macaca mulatta	KLHDC8A	VGNC	VGNC:74124
Felis catus	KLHDC8A	VGNC	VGNC:63139
Bos taurus	KLHDC8A	VGNC	VGNC:30639
Canis familiaris	KLHDC8A	VGNC	VGNC:42443
Rattus norvegicus	KLHDC8A	RGD	RGD:1305132

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