KLHDC8A - kelch domain containing 8A Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55220

About KLHDC8A

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:205,336,061-205,357,039 (from NCBI)

This gene has 12 transcripts (splice variants), 126 orthologues and 54 paralogues. Biased expression in ovary (RPKM 76.6) and adrenal (RPKM 7.3).

Summary

This gene encodes a kelch domain-containing protein which is upregulated in Cancer. Upregulated expression of the encoded protein may provide an alternative pathway for tumors to maintain aggressiveness in the absence of epidermal growth factor receptor dependence. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

KLHDC8A Products (4)

mRNA Protein Name
NM_001271863.2 NP_001258792.1 kelch domain-containing protein 8A
NM_001271864.2 NP_001258793.1 kelch domain-containing protein 8A
NM_001271865.2 NP_001258794.1 kelch domain-containing protein 8A
NM_018203.3 NP_060673.1 kelch domain-containing protein 8A

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
25036637 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLHDC8A Protein Structure

Kelch_1

Kelch_1: Kelch motif (20 - 66)

Kelch_1

Kelch_1: Kelch motif (68 - 111)

Kelch_6

Kelch_6: Kelch motif (165 - 212)

Kelch_6

Kelch_6: Kelch motif (269 - 316)

  • 0
  • 100
  • 200
  • 300
  • 350 a.a.
Protein Preferred Names Protein Names

kelch domain-containing protein 8A

  • S-delta-E1

KLHDC8A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
KLHDC8A Q8IYD2 NUDCD3 Homo sapiens Q8IVD9
Anti Tag CoIP
33961781
Intra
KLHDC8A Q8IYD2 NUDCD3 Homo sapiens Q8IVD9
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Astrocytoma, Idh-Mutant, Grade 4

  • Idh-Mutant Glioblastoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS07352 KLHDC8A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus KLHDC8A MGD MGI:2442630
Macaca mulatta KLHDC8A VGNC VGNC:74124
Felis catus KLHDC8A VGNC VGNC:63139
Bos taurus KLHDC8A VGNC VGNC:30639
Canis familiaris KLHDC8A VGNC VGNC:42443
Rattus norvegicus KLHDC8A RGD RGD:1305132
Others KLHDC8A NCBI