G2E3 - G2/M-phase specific E3 ubiquitin protein ligase Gene

Homo sapiens

Also known as PHF7B; KIAA1333

Gene ID: 55632 | Gene type: protein coding

About G2E3

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:30,559,158-30,620,064 (from NCBI)

This gene has 15 transcripts (splice variants), 213 orthologues and 3 paralogues. Broad expression in testis (RPKM 10.5), lymph node (RPKM 4.4) and 24 other tissues.

Summary

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in apoptotic process and protein ubiquitination. Predicted to act upstream of or within blastocyst development; negative regulation of intrinsic apoptotic signaling pathway; and protein polyubiquitination. Located in Golgi apparatus and cytosol. [provided by Alliance of Genome Resources, Apr 2022]

G2E3 Products(2)

mRNA	Protein	Name
NM_001308097.2	NP_001295026.1	G2/M phase-specific E3 ubiquitin-protein ligase isoform 2
NM_017769.5	NP_060239.2	G2/M phase-specific E3 ubiquitin-protein ligase isoform 1

G2E3 Protein Structure

zf-HC5HC2H

HECT

0
200
400
600
706 a.a.

Protein Preferred Names

Protein Names

G2/M phase-specific E3 ubiquitin-protein ligase

G2/M phase-specific HECT-type E3 ubiquitin transferase

Related Diseases

Diseases

Alias

Achondrogenesis, Type Ia

Achondrogenesis Type Ia	Achondrogenesis Type 1a
ACG1A	Achondrogenesis, Houston-Harris Type
Achondrogenesis Houston-Harris Type	Achondrogenesis 1a
Acg-Ia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05188	G2E3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	G2E3	VGNC	VGNC:29175
Mus musculus	G2E3	MGD	MGI:2444298
Felis catus	G2E3	VGNC	VGNC:80969
Canis familiaris	G2E3	VGNC	VGNC:41037
Rattus norvegicus	G2E3	RGD	RGD:1310263
Macaca mulatta	G2E3	VGNC	VGNC:72753