G2E3 - G2/M-phase specific E3 ubiquitin protein ligase Gene

Also Known as PHF7B; KIAA1333

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55632

About G2E3

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:30,559,158-30,620,064 (from NCBI)

This gene has 15 transcripts (splice variants), 213 orthologues and 3 paralogues. Broad expression in testis (RPKM 10.5), lymph node (RPKM 4.4) and 24 other tissues.

Summary

Predicted to enable ubiquitin protein Ligase activity. Predicted to be involved in apoptotic process and protein ubiquitination. Predicted to act upstream of or within blastocyst development; negative regulation of intrinsic apoptotic signaling pathway; and protein polyubiquitination. Located in Golgi apparatus and cytosol. [provided by Alliance of Genome Resources, Apr 2022]

G2E3 Products (2)

mRNA	Protein	Name
NM_001308097.2	NP_001295026.1	G2/M phase-specific E3 ubiquitin-protein ligase isoform 2
NM_017769.5	NP_060239.2	G2/M phase-specific E3 ubiquitin-protein ligase isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

G2E3 Protein Structure

zf-HC5HC2H

HECT

0
200
400
600
706 a.a.

Protein Preferred Names	Protein Names
G2/M phase-specific E3 ubiquitin-protein ligase	G2/M phase-specific HECT-type E3 ubiquitin transferase

G2E3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	G2E3	Q7L622	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	G2E3	Q7L622	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	G2E3	Q7L622	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	G2E3	Q7L622	SPECC1L	Homo sapiens	Q69YQ0	Anti Tag CoIP	28514442
Intra	G2E3	Q7L622	SPECC1L	Homo sapiens	Q69YQ0	Anti Tag CoIP	33961781
Intra	G2E3	Q7L622	RPS15	Homo sapiens	P62841	Validated Y2H	25416956
Intra	G2E3	Q7L622	RPS15	Homo sapiens	P62841	Y2H Prey Pooling	25416956
Intra	G2E3	Q7L622	NEFL	Homo sapiens	P07196	Validated Y2H	32814053
Intra	G2E3	Q7L622	NEFL	Homo sapiens	P07196	Y2H Array	32814053
Intra	G2E3	Q7L622	NEFL	Homo sapiens	P07196	Y2H Pooling	32814053
Intra	G2E3	Q7L622	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	G2E3	Q7L622	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	G2E3	Q7L622	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	G2E3	Q7L622	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	G2E3	Q7L622	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	G2E3	Q7L622	WFS1	Homo sapiens	O76024	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Achondrogenesis, Type Ia	Achondrogenesis Type Ia Achondrogenesis Type 1a ACG1A Achondrogenesis, Houston-Harris Type Achondrogenesis Houston-Harris Type Achondrogenesis 1a Acg-Ia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05188	G2E3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	G2E3	VGNC	VGNC:29175
Mus musculus	G2E3	MGD	MGI:2444298
Felis catus	G2E3	VGNC	VGNC:80969
Canis familiaris	G2E3	VGNC	VGNC:41037
Rattus norvegicus	G2E3	RGD	RGD:1310263
Macaca mulatta	G2E3	VGNC	VGNC:72753
Others	G2E3	NCBI