SLC50A1 - solute carrier family 50 member 1 Gene

Also Known as SCP; slv; SWEET1; RAG1AP1; HsSWEET1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55974

About SLC50A1

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:155,135,375-155,138,853 (from NCBI)

This gene has 15 transcripts (splice variants) and 211 orthologues. Ubiquitous expression in colon (RPKM 17.3), stomach (RPKM 15.0) and 25 other tissues.

Summary

Enables glucoside transmembrane transporter activity. Predicted to be involved in carbohydrate transport. Located in Golgi apparatus and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC50A1 Products (10)

mRNA Protein Name
NM_001122837.2 NP_001116309.1 sugar transporter SWEET1 isoform b
NM_001122839.2 NP_001116311.1 sugar transporter SWEET1 isoform c
NM_001287586.2 NP_001274515.1 sugar transporter SWEET1 isoform d
NM_001287587.2 NP_001274516.1 sugar transporter SWEET1 isoform e
NM_001287588.2 NP_001274517.1 sugar transporter SWEET1 isoform f
NM_001287589.2 NP_001274518.1 sugar transporter SWEET1 isoform g
NM_001287590.2 NP_001274519.1 sugar transporter SWEET1 isoform h
NM_001287591.2 NP_001274520.1 sugar transporter SWEET1 isoform i
NM_001287592.2 NP_001274521.1 sugar transporter SWEET1 isoform j
NM_018845.4 NP_061333.2 sugar transporter SWEET1 isoform a

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glucoside transmembrane transporter activity IDA
IDA: Inferred from direct assay
21107422 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
21107422 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
21107422 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC50A1 Protein Structure

MtN3_slv

MtN3_slv: Sugar efflux transporter for intercellular exchange (10 - 95)

MtN3_slv

MtN3_slv: Sugar efflux transporter for intercellular exchange (127 - 212)

  • 0
  • 100
  • 200
  • 221 a.a.
Protein Preferred Names Protein Names

sugar transporter SWEET1

  • RAG1-activating protein 1

SLC50A1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SLC50A1 Q9BRV3 SMG9 Homo sapiens Q9H0W8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Bladder Transitional Cell Papilloma

  • Bladder Papilloma

  • Transitional Cell Papilloma Of Bladder

  • Urinary Bladder Urothelial Papilloma

  • Urothelial Papilloma

  • Bladder Urothelial Papilloma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13275 SLC50A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SLC50A1 VGNC VGNC:46439
Felis catus SLC50A1 VGNC VGNC:65394
Rattus norvegicus SLC50A1 RGD RGD:1308478
Macaca mulatta SLC50A1 VGNC VGNC:77799
Bos taurus SLC50A1 VGNC VGNC:34899
Mus musculus SLC50A1 MGD MGI:107417
Others SLC50A1 NCBI