Panx1 - pannexin 1 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 55991

Summary

Enables actin filament binding activity and channel activity. Acts upstream of or within several processes, including positive regulation of interleukin-1 production; response to ATP; and response to ischemia. Located in plasma membrane. Is expressed in several structures, including male reproductive gland or organ; metanephros; nervous system; sensory organ; and submandibular gland primordium. Orthologous to human PANX1 (pannexin 1). [provided by Alliance of Genome Resources, Apr 2022]

Panx1 Products (1)

mRNA Protein Name
NM_019482.2 NP_062355.2 pannexin-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin binding IPI
IPI: Inferred from physical interaction
20086016 MGI
enables actin filament binding IDA
IDA: Inferred from direct assay
20086016 MGI
enables monoatomic anion channel activity IDA
IDA: Inferred from direct assay
22311122 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19780818 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of interleukin-1 alpha production IMP
IMP: Inferred from mutant phenotype
18490713 MGI
acts upstream of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
18490713 MGI
acts upstream of macrophage cytokine production IMP
IMP: Inferred from mutant phenotype
18490713 MGI
involved in monoatomic anion transmembrane transport IDA
IDA: Inferred from direct assay
22311122 MGI
acts upstream of or within positive regulation of interleukin-1 alpha production IMP
IMP: Inferred from mutant phenotype
18490713 MGI
acts upstream of or within positive regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
18490713 MGI
acts upstream of or within positive regulation of macrophage cytokine production IMP
IMP: Inferred from mutant phenotype
18490713 MGI
acts upstream of or within response to ATP IMP
IMP: Inferred from mutant phenotype
18490713 MGI
acts upstream of or within response to ischemia IGI
IGI: Inferred from genetic interaction
22147915 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
20086016 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pannexin-1

Panx1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Panx1 Q9JIP4 Kcnab3 Mus musculus P97382
Anti Tag CoIP
19780818
Cross: Cross-species interaction Intra: Intraspecies interaction

Orthologs Information

Species Symbol Source ID
Homo sapiens Panx1 NCBI NCBI:24145