Clec7a - C-type lectin domain family 7, member a Gene

Also Known as BGR; beta-GR; Clecsf12

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56644

Summary

Predicted to enable (1->3)-beta-D-glucan binding activity and pattern recognition receptor activity. Predicted to be involved in several processes, including phagocytosis, recognition; positive regulation of cytokine production involved in inflammatory response; and response to fungus. Predicted to be active in cell surface. Is expressed in brain; gut; limb; musculature; and ventral grey horn. Human ortholog(s) of this gene implicated in aspergillosis and chronic mucocutaneous candidiasis. Orthologous to human CLEC7A (C-type lectin domain containing 7A). [provided by Alliance of Genome Resources, Apr 2022]

Clec7a Products (2)

mRNA Protein Name
NM_001309637.2 NP_001296566.1 C-type lectin domain family 7 member A isoform 2
NM_020008.4 NP_064392.2 C-type lectin domain family 7 member A isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables (1->3)-beta-D-glucan binding IDA
IDA: Inferred from direct assay
12163569 MGI
enables (1->3)-beta-D-glucan immune receptor activity IDA
IDA: Inferred from direct assay
12719478 MGI
enables opsonin binding IDA
IDA: Inferred from direct assay
12163569 MGI
enables pattern recognition receptor activity IDA
IDA: Inferred from direct assay
19136564 MGI
enables pattern recognition receptor activity IMP
IMP: Inferred from mutant phenotype
15213161 MGI
enables polysaccharide binding IDA
IDA: Inferred from direct assay
12163569 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15845454 MGI
Biological Process GO Annotation Evidence References Source
involved in antifungal innate immune response IDA
IDA: Inferred from direct assay
19136564 MGI
involved in antifungal innate immune response IMP
IMP: Inferred from mutant phenotype
17159984 MGI
involved in cell activation IDA
IDA: Inferred from direct assay
19136564 MGI
acts upstream of or within cell surface pattern recognition receptor signaling pathway IDA
IDA: Inferred from direct assay
12719478 MGI
acts upstream of or within cell-cell adhesion IDA
IDA: Inferred from direct assay
14698225 MGI
involved in cellular response to molecule of fungal origin IDA
IDA: Inferred from direct assay
15845454 MGI
involved in detection of molecule of fungal origin IDA
IDA: Inferred from direct assay
15213161 MGI
acts upstream of or within detection of yeast IDA
IDA: Inferred from direct assay
14698225 MGI
involved in detection of yeast IDA
IDA: Inferred from direct assay
19136564 MGI
involved in innate immune response IDA
IDA: Inferred from direct assay
15845454 MGI
involved in leukocyte activation involved in immune response IDA
IDA: Inferred from direct assay
15845454 MGI
acts upstream of or within phagocytosis, engulfment IDA
IDA: Inferred from direct assay
14707091 MGI
acts upstream of or within phagocytosis, recognition IDA
IDA: Inferred from direct assay
14707091 MGI
acts upstream of or within positive regulation of DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
19136564 MGI
involved in positive regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
19136564 MGI
involved in positive regulation of T-helper 17 type immune response IMP
IMP: Inferred from mutant phenotype
32358020 MGI
acts upstream of positive regulation of calcium-mediated signaling IDA
IDA: Inferred from direct assay
19136564 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
15213161 MGI
involved in positive regulation of cytokine production involved in immune response IDA
IDA: Inferred from direct assay
27288407 MGI
involved in positive regulation of dendritic cell cytokine production IDA
IDA: Inferred from direct assay
27288407 MGI
involved in positive regulation of dendritic cell cytokine production IMP
IMP: Inferred from mutant phenotype
19136564 MGI
involved in positive regulation of interleukin-10 production IMP
IMP: Inferred from mutant phenotype
19136564 MGI
involved in positive regulation of interleukin-2 production IMP
IMP: Inferred from mutant phenotype
19136564 MGI
involved in positive regulation of interleukin-23 production IMP
IMP: Inferred from mutant phenotype
19136564 MGI
involved in positive regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
19136564 MGI
involved in positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
27288407 MGI
acts upstream of or within positive regulation of phagocytosis IDA
IDA: Inferred from direct assay
14707091 MGI
involved in positive regulation of stress-activated MAPK cascade IDA
IDA: Inferred from direct assay
27288407 MGI
acts upstream of or within positive regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
12719478 MGI
involved in positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
19136564 MGI
acts upstream of or within regulation of calcineurin-NFAT signaling cascade IMP
IMP: Inferred from mutant phenotype
19136564 MGI
involved in regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
19136564 MGI
acts upstream of or within response to molecule of fungal origin IDA
IDA: Inferred from direct assay
12719478 MGI
acts upstream of or within response to yeast IDA
IDA: Inferred from direct assay
12719478 MGI
involved in response to yeast IDA
IDA: Inferred from direct assay
19136564 MGI
involved in stimulatory C-type lectin receptor signaling pathway IDA
IDA: Inferred from direct assay
19136564 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
12163569 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

C-type lectin domain family 7 member A

  • C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12

  • C-type lectin superfamily member 12

  • DC-associated C-type lectin 1

  • beta-glucan receptor

  • dectin-1

  • dendritic cell-associated C-type lectin 1

Recombinant Clec7a Proteins

Cat. No. Product Name Accession Purity
HY-P75296 Dectin-1/CLEC7A Protein, Mouse (HEK293, His, solution) NP_064392.2 (F69-L244) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700694 Dectin-1/CLEC7A Protein, Mouse (HEK293, Fc) Q6QLQ4 (G71-L244) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-147295 Odetiglucan Agonist / Phase 3

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS17778 Clec7a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02800 CLEC7A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24245 Clec7a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990374 Anti-CLEC7A Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Clec7a NCBI NCBI:64581