NMUR2 - neuromedin U receptor 2 Gene

Also Known as FM4; FM-4; TGR1; NMU2R; TGR-1; NMU-R2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56923

About NMUR2

Cytogenetic location: 5q33.1 Genomic coordinates (GRCh38): 5:152,391,546-152,405,279 (from NCBI)

This gene has 2 transcripts (splice variants), 131 orthologues and 15 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a protein from the G-protein coupled receptor 1 family. This protein is a receptor for neuromedin U, which is a neuropeptide that is widely distributed in the gut and central nervous system. This receptor plays an important role in the regulation of food intake and body weight. [provided by RefSeq, Jul 2008]

NMUR2 Products (1)

mRNA Protein Name
NM_020167.5 NP_064552.3 neuromedin-U receptor 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTP binding IDA
IDA: Inferred from direct assay
10899166 GOA
enables intracellularly calcium-gated chloride channel activity IDA
IDA: Inferred from direct assay
10899166 GOA
enables neuromedin U binding IDA
IDA: Inferred from direct assay
10894543 GOA
enables neuromedin U receptor activity IDA
IDA: Inferred from direct assay
10887190 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in arachidonate secretion IDA
IDA: Inferred from direct assay
10887190 GOA
involved in neuropeptide signaling pathway IDA
IDA: Inferred from direct assay
10894543 GOA
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
10899166 GOA
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
10899166 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NMUR2 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (62 - 327)

  • 0
  • 100
  • 200
  • 300
  • 415 a.a.
Protein Preferred Names Protein Names

neuromedin-U receptor 2

  • G-protein coupled receptor FM-4

NMUR2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NMUR2 Q9GZQ4 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
25416956
Intra
NMUR2 Q9GZQ4 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
25416956
Intra
NMUR2 Q9GZQ4 TRAF2 Homo sapiens Q12933
Y2H Array
25416956
Intra
NMUR2 Q9GZQ4 TCF4 Homo sapiens P15884
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P3030 CPN-219 Agonist 99.08% Unkown
HY-P3135 CPN-116 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris NMUR2 VGNC VGNC:43867
Felis catus NMUR2 VGNC VGNC:63842
Bos taurus NMUR2 VGNC VGNC:32141
Rattus norvegicus NMUR2 RGD RGD:621155
Mus musculus NMUR2 MGD MGI:2441765
Macaca mulatta NMUR2 VGNC VGNC:75189
Others NMUR2 NCBI