PSMG2 - proteasome assembly chaperone 2 Gene

Also Known as PAC2; HCCA3; CLAST3; MDS003; PRAAS4; HsT1707; TNFSF5IP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56984

About PSMG2

Cytogenetic location: 18p11.21 Genomic coordinates (GRCh38): 18:12,658,738-12,725,740 (from NCBI)

This gene has 23 transcripts (splice variants), 218 orthologues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 46.4), bone marrow (RPKM 28.3) and 25 other tissues.

Summary

Enables molecular adaptor activity. Involved in chaperone-mediated protein complex assembly. Located in nucleus. Part of chaperone complex. [provided by Alliance of Genome Resources, Apr 2022]

PSMG2 Products (2)

mRNA Protein Name
NM_020232.5 NP_064617.2 proteasome assembly chaperone 2 isoform 1
NM_147163.2 NP_671692.1 proteasome assembly chaperone 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables molecular adaptor activity IGI
IGI: Inferred from genetic interaction
17189198 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16251969 GOA
Biological Process GO Annotation Evidence References Source
involved in chaperone-mediated protein complex assembly IDA
IDA: Inferred from direct assay
16251969 GOA
involved in chaperone-mediated protein complex assembly IGI
IGI: Inferred from genetic interaction
17189198 GOA
Cellular Component GO Annotation Evidence References Source
part of protein folding chaperone complex IDA
IDA: Inferred from direct assay
16251969 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMG2 Protein Structure

PAC2

PAC2: PAC2 family (17 - 226)

  • 0
  • 100
  • 200
  • 264 a.a.
Protein Preferred Names Protein Names

proteasome assembly chaperone 2

  • CD40 ligand-activated specific transcript 3

PSMG2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PSMG2 Q969U7 TCF4 Homo sapiens P15884
Validated Y2H
25416956
Intra
PSMG2 Q969U7 TCF4 Homo sapiens P15884
Y2H Prey Pooling
25416956
Intra
PSMG2 Q969U7 PSMG1 Homo sapiens O95456
Anti Tag CoIP
33961781
Intra
PSMG2 Q969U7 PSMG1 Homo sapiens O95456
Y2H Prey Pooling
32296183
Intra
PSMG2 Q969U7 PSMG1 Homo sapiens O95456
Anti Tag CoIP
35271311
Intra
PSMG2 Q969U7 PSMG1 Homo sapiens O95456
Y2H Array
32296183
Intra
PSMG2 Q969U7 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
Intra
PSMG2 Q969U7 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
Intra
PSMG2 Q969U7 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
PSMG2 Q969U7 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
25416956
Intra
PSMG2 Q969U7 KRT31 Homo sapiens Q15323
Y2H Array
25416956
Intra
PSMG2 Q969U7 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Proteasome-Associated Autoinflammatory Syndrome 4

  • PRAAS4
Panniculitis

  • Nodular Panniculitis
Proteasome-Associated Autoinflammatory Syndrome

  • Aldd Syndrome

  • Autoinflammation-Lipodystrophy-Dermatosis Syndrome

  • Praas

  • Proteasome Disability Syndrome
Solitary Median Maxillary Central Incisor

  • SMMCI

  • Fused Incisors

  • Single Upper Central Incisor

  • Single Central Maxillary Incisor

  • Single Median Maxillary Central Incisor

  • Solitary Median Maxillary Central Incisor Syndrome

  • Incisors Fused

  • Incisors, Fused
Hemolytic Anemia

  • Anemia, Hemolytic

  • Anemia Hemolytic

  • Anaemia Due To Other Disorders Of Glutathione Metabolism

  • Chronic Non Spherocytic Anaemia

  • G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia

  • Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency

  • Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia

  • Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia

  • Favism Anaemia

  • Haemolytic Anaemia Due Tog6pd Deficiency

  • Favism

  • Pentose Phosphate Pathway Disorder Anaemia

  • Anaemia Due To Pentose Phosphate Pathway Defect
Basal Ganglia Calcification

  • Fahr'S Syndrome

  • Fahr'S Disease

  • Fahr Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11337 PSMG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PSMG2 VGNC VGNC:33479
Rattus norvegicus PSMG2 RGD RGD:1304867
Mus musculus PSMG2 MGD MGI:1922901
Felis catus PSMG2 VGNC VGNC:107719
Canis familiaris PSMG2 VGNC VGNC:45122
Others PSMG2 NCBI