PSMG1 - proteasome assembly chaperone 1 Gene

Also Known as PAC1; DSCR2; PAC-1; C21LRP; LRPC21

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8624

About PSMG1

Cytogenetic location: 21q22.2 Genomic coordinates (GRCh38): 21:39,174,769-39,183,514 (from NCBI)

This gene has 5 transcripts (splice variants) and 193 orthologues. Broad expression in testis (RPKM 57.7), thyroid (RPKM 14.4) and 23 other tissues.

Summary

Enables molecular adaptor activity. Involved in chaperone-mediated protein complex assembly. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and nucleoplasm. Part of chaperone complex. [provided by Alliance of Genome Resources, Apr 2022]

PSMG1 Products (4)

mRNA Protein Name
NM_001261824.1 NP_001248753.1 proteasome assembly chaperone 1 isoform 3
NM_001320795.1 NP_001307724.1 proteasome assembly chaperone 1 isoform d
NM_003720.4 NP_003711.1 proteasome assembly chaperone 1 isoform a
NM_203433.2 NP_982257.1 proteasome assembly chaperone 1 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
16251969 GOA
enables molecular adaptor activity IGI
IGI: Inferred from genetic interaction
17189198 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16251969 GOA
Biological Process GO Annotation Evidence References Source
involved in chaperone-mediated protein complex assembly IDA
IDA: Inferred from direct assay
16251969 GOA
involved in chaperone-mediated protein complex assembly IGI
IGI: Inferred from genetic interaction
17189198 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15670775 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
15590417 GOA
part of protein folding chaperone complex IDA
IDA: Inferred from direct assay
16251969 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

proteasome assembly chaperone 1

  • Down syndrome critical region gene 2

PSMG1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PSMG1 O95456 PRKAR1B Homo sapiens P31321
Validated Y2H
32296183
Intra
PSMG1 O95456 PRKAR1B Homo sapiens P31321
Y2H Prey Pooling
32296183
Intra
PSMG1 O95456 PRKAR1B Homo sapiens P31321
Y2H Array
32296183
Intra
PSMG1 O95456 PSMG2 Homo sapiens Q969U7
Y2H Fragment Pooling
35914814
Intra
PSMG1 O95456 PSMG2 Homo sapiens Q969U7
Y2H Prey Pooling
32296183
Intra
PSMG1 O95456 PSMG2 Homo sapiens Q969U7
Validated Y2H
32296183
Intra
PSMG1 O95456 PSMG2 Homo sapiens Q969U7
Anti Tag CoIP
35271311
Intra
PSMG1 O95456 PSMG2 Homo sapiens Q969U7
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Down Syndrome

  • Trisomy 21

  • Complete Trisomy 21 Syndrome

  • Down'S Syndrome

  • Trisomy 21 Syndrome

  • Down'S Syndrome - Trisomy 21

  • Downs Syndrome

  • G Trisomy

  • 47,Xx,+21

  • 47,Xy,+21

  • Trisomy G

  • Down Syndrome, Susceptibility To

  • Chromosome 21 Trisomy

  • Trisomy 21 Nos

  • Abnormal Autosomes 21
Thrombasthenia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11336 PSMG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PSMG1 RGD RGD:1305454
Bos taurus PSMG1 VGNC VGNC:33478
Mus musculus PSMG1 MGD MGI:1860263
Macaca mulatta PSMG1 VGNC VGNC:76347
Canis familiaris PSMG1 VGNC VGNC:45121
Felis catus PSMG1 VGNC VGNC:102810
Others PSMG1 NCBI