PSMD11 - proteasome 26S subunit, non-ATPase 11 Gene

Also Known as S9; Rpn6; p44.5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5717

About PSMD11

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:32,444,510-32,483,319 (from NCBI)

This gene has 12 transcripts (splice variants), 288 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 16.9), placenta (RPKM 15.8) and 25 other tissues.

Summary

The 26S Proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the Proteasome subunit S9 family that functions as a non-ATPase subunit of the 19S regulator and is phosphorylated by AMP-activated protein kinase. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

PSMD11 Products (2)

mRNA	Protein	Name
NM_001270482.2	NP_001257411.1	26S proteasome non-ATPase regulatory subunit 11
NM_002815.4	NP_002806.2	26S proteasome non-ATPase regulatory subunit 11

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16990800	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in proteasome assembly	IMP IMP: Inferred from mutant phenotype	22972301	GOA
involved in stem cell differentiation	IMP IMP: Inferred from mutant phenotype	22972301	GOA
involved in ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	22972301	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of proteasome accessory complex	IDA IDA: Inferred from direct assay	22972301	GOA
part of proteasome complex	IDA IDA: Inferred from direct assay	17323924	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMD11 Protein Structure

PCI

0
100
200
300
400
422 a.a.

Protein Preferred Names	Protein Names
26S proteasome non-ATPase regulatory subunit 11	26S proteasome regulatory subunit 9

PSMD11 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PSMD11	O00231	COPS2	Homo sapiens	P61201	Validated Y2H	32296183
Intra	PSMD11	O00231	PRKAB2	Homo sapiens	O43741	Validated Y2H	32296183
Intra	PSMD11	O00231	PSMD4	Homo sapiens	P55036	3D-EM-Single	27342858
Intra	PSMD11	O00231	PRMT6	Homo sapiens	Q96LA8	Anti Tag CoIP	23455924
Intra	PSMD11	O00231	PRMT6	Homo sapiens	Q96LA8	Y2H	23455924

Cross: Cross-species interaction Intra: Intraspecies interaction

PSMD11 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P85893	PSMD11 Antibody (YA5585)	WB, ICC/IF, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11319	PSMD11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PSMD11	RGD	RGD:1306450
Macaca mulatta	PSMD11	VGNC	VGNC:76450
Canis familiaris	PSMD11	VGNC	VGNC:45107
Felis catus	PSMD11	VGNC	VGNC:69119
Bos taurus	PSMD11	VGNC	VGNC:33462
Mus musculus	PSMD11	MGD	MGI:1916327
Others	PSMD11	NCBI