Jmy - junction-mediating and regulatory protein Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 57748

Summary

Enables transcription coactivator activity. Involved in several processes, including actin nucleation; actin polymerization-dependent cell motility; and positive regulation of DNA-binding transcription factor activity. Acts upstream of or within intrinsic apoptotic signaling pathway by p53 class mediator and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in skeletal muscle. Orthologous to human JMY (junction mediating and regulatory protein, p53 cofactor). [provided by Alliance of Genome Resources, Apr 2022]

Jmy Products (1)

mRNA Protein Name
NM_021310.3 NP_067285.2 junction-mediating and -regulatory protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10518217 MGI
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
10518217 MGI
Biological Process GO Annotation Evidence References Source
involved in 'de novo' actin filament nucleation IDA
IDA: Inferred from direct assay
19287377 MGI
involved in Arp2/3 complex-mediated actin nucleation IDA
IDA: Inferred from direct assay
19287377 MGI
involved in actin polymerization-dependent cell motility IDA
IDA: Inferred from direct assay
19287377 MGI
acts upstream of or within intrinsic apoptotic signaling pathway by p53 class mediator IDA
IDA: Inferred from direct assay
10518217 MGI
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
10518217 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10518217 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
19287377 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

junction-mediating and -regulatory protein

  • p300 transcriptional cofactor JMY

Jmy Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Jmy Q9QXM1 EP300 Homo sapiens Q09472
Anti Bait CoIP
10518217
Cross
Jmy Q9QXM1 EP300 Homo sapiens Q09472
Y2H
10518217
Cross
Jmy Q9QXM1 EP300 Homo sapiens Q09472
Pull Down
10518217
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07042 JMY Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Jmy NCBI NCBI:133746