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CCAR2 - cell cycle and apoptosis regulator 2 Gene

Also Known as DBC1; DBC-1; NET35; p30DBC; p30 DBC; KIAA1967

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57805

About CCAR2

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:22,604,757-22,621,514 (from NCBI)

This gene has 13 transcripts (splice variants), 137 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 30.7), brain (RPKM 20.0) and 25 other tissues.

Summary

Enables RNA polymerase II complex binding activity and enzyme inhibitor activity. Involved in several processes, including regulation of cellular protein metabolic process; regulation of signal transduction; and regulation of transcription, DNA-templated. Located in several cellular components, including mitochondrial matrix; nucleoplasm; and spindle. Part of DBIRD complex. [provided by Alliance of Genome Resources, Apr 2022]

CCAR2 Products (4)

mRNA	Protein	Name
NM_001363068.2	NP_001349997.1	cell cycle and apoptosis regulator protein 2 isoform 2
NM_001363069.2	NP_001349998.1	cell cycle and apoptosis regulator protein 2 isoform 2
NM_001393997.1	NP_001380926.1	cell cycle and apoptosis regulator protein 2 isoform 1
NM_021174.6	NP_066997.3	cell cycle and apoptosis regulator protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II complex binding	IDA IDA: Inferred from direct assay	22446626	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	18235501	GOA
enables enzyme inhibitor activity	IDA IDA: Inferred from direct assay	18235501	GOA
enables enzyme inhibitor activity	IMP IMP: Inferred from mutant phenotype	19218236	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17314511	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in RNA splicing	IMP IMP: Inferred from mutant phenotype	22446626	GOA
involved in mitochondrial fragmentation involved in apoptotic process	IDA IDA: Inferred from direct assay	15824730	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20160719	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20074560	GOA
involved in negative regulation of catalytic activity	IMP IMP: Inferred from mutant phenotype	21030595	GOA
involved in negative regulation of cell growth	IMP IMP: Inferred from mutant phenotype	25661920	GOA
involved in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IMP IMP: Inferred from mutant phenotype	23352644	GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	23398316	GOA
involved in positive regulation of DNA damage checkpoint	IMP IMP: Inferred from mutant phenotype	23352644	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18235501	GOA
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	24824780	GOA
involved in regulation of DNA-templated transcription elongation	IMP IMP: Inferred from mutant phenotype	22446626	GOA
involved in regulation of protein deacetylation	IDA IDA: Inferred from direct assay	21030595	GOA
involved in regulation of protein stability	IDA IDA: Inferred from direct assay	23398316	GOA
involved in response to UV	IMP IMP: Inferred from mutant phenotype	23352644	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of DBIRD complex	IDA IDA: Inferred from direct assay	22446626	GOA
located in chromatin	IDA IDA: Inferred from direct assay	23352644	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15824730	GOA
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	15824730	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15824730	GOA
located in spindle	IDA IDA: Inferred from direct assay	18445686	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCAR2 Protein Structure

S1-like

DBC1

0
200
400
600
800
923 a.a.

Protein Preferred Names	Protein Names
cell cycle and apoptosis regulator protein 2	cell division cycle and apoptosis regulator protein 2

CCAR2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CCAR2	Q8N163	ZNF335	Homo sapiens	Q9H4Z2	Anti Bait CoIP	19131338
Intra	CCAR2	Q8N163	ZNF335	Homo sapiens	Q9H4Z2	Y2H	19131338
Intra	CCAR2	Q8N163	MYC	Homo sapiens	P01106	Density Sedimentation	17314511
Intra	CCAR2	Q8N163	TTR	Homo sapiens	P02766	Validated Y2H	32814053
Intra	CCAR2	Q8N163	TTR	Homo sapiens	P02766	Y2H Array	32814053
Intra	CCAR2	Q8N163	TTR	Homo sapiens	P02766	Y2H Pooling	32814053
Intra	CCAR2	Q8N163	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	CCAR2	Q8N163	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	CCAR2	Q8N163	WFS1	Homo sapiens	O76024	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

CCAR2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81269	DBC 1 Antibody (YA955)	WB, ICC/IF, IP	Human, Mouse, Rat, Monkey
HY-P81269A	DBC 1 Antibody (YA956)	WB, IHC-F, IHC-P, ICC/IF, IP	Human
HY-P81269AA	DBC 1 Antibody (YA956)(PBS only)	WB, IHC-F, IHC-P, ICC/IF, IP	Human
HY-P85490	DBC 1 Antibody (YA5182)	WB, ICC/IF, IP	Human, Mouse, Rat, Monkey

Related Diseases

Diseases	Alias
Encephalopathy, Neonatal Severe, Due To Mecp2 Mutations	Severe Congenital Encephalopathy Due To Mecp2 Mutation Severe Neonatal-Onset Encephalopathy With Microcephaly Encephalopathy, Neonatal Severe Neonatal Severe Encephalopathy Due To Mecp2 Mutations Mecp2-Related Severe Neonatal Encephalopathy Methyl-Cytosine Phosphate Guanine Binding Protein 2 Related Severe Neonatal Encephalopathy Severe Neonatal Encephalopathy Due To Mecp2 Mutations ENS-MECP2 Encephalopathy, Neonatal, Severe
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02021	CCAR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CCAR2	RGD	RGD:1309922
Bos taurus	CCAR2	VGNC	VGNC:26827
Canis familiaris	CCAR2	VGNC	VGNC:38774
Mus musculus	CCAR2	MGD	MGI:2444228
Macaca mulatta	CCAR2	VGNC	VGNC:70611
Felis catus	CCAR2	VGNC	VGNC:60443
Others	CCAR2	NCBI