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  2. CCAR2 - cell cycle and apoptosis regulator 2 Gene

CCAR2 - cell cycle and apoptosis regulator 2 Gene

Homo sapiens

Also known as DBC1; DBC-1; NET35; p30DBC; p30 DBC; KIAA1967

Gene ID: 57805 | Gene type: protein coding

About CCAR2

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:22,604,757-22,621,514 (from NCBI)

This gene has 13 transcripts (splice variants), 137 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 30.7), brain (RPKM 20.0) and 25 other tissues.

Summary

Enables RNA polymerase II complex binding activity and Enzyme inhibitor activity. Involved in several processes, including regulation of cellular protein metabolic process; regulation of signal transduction; and regulation of transcription, DNA-templated. Located in several cellular components, including mitochondrial matrix; nucleoplasm; and spindle. Part of DBIRD complex. [provided by Alliance of Genome Resources, Apr 2022]

CCAR2 Products(4)

mRNA Protein Name
NM_001363068.2 NP_001349997.1 cell cycle and apoptosis regulator protein 2 isoform 2
NM_001363069.2 NP_001349998.1 cell cycle and apoptosis regulator protein 2 isoform 2
NM_001393997.1 NP_001380926.1 cell cycle and apoptosis regulator protein 2 isoform 1
NM_021174.6 NP_066997.3 cell cycle and apoptosis regulator protein 2 isoform 1

CCAR2 Protein Structure

S1-like

S1-like: S1-like (55 - 112)

DBC1

DBC1: DBC1 (340 - 461)

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  • 923 a.a.
Protein Preferred Names Protein Names

cell cycle and apoptosis regulator protein 2

cell division cycle and apoptosis regulator protein 2

Related Diseases

Diseases Alias
Encephalopathy, Neonatal Severe, Due To Mecp2 Mutations

Severe Congenital Encephalopathy Due To Mecp2 Mutation

Severe Neonatal-Onset Encephalopathy With Microcephaly

Encephalopathy, Neonatal Severe

Neonatal Severe Encephalopathy Due To Mecp2 Mutations

Mecp2-Related Severe Neonatal Encephalopathy

Methyl-Cytosine Phosphate Guanine Binding Protein 2 Related Severe Neonatal Encephalopathy

Severe Neonatal Encephalopathy Due To Mecp2 Mutations

ENS-MECP2

Encephalopathy, Neonatal, Severe

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CCAR2 RGD RGD:1309922
Bos taurus CCAR2 VGNC VGNC:26827
Canis familiaris CCAR2 VGNC VGNC:38774
Mus musculus CCAR2 MGD MGI:2444228
Macaca mulatta CCAR2 VGNC VGNC:70611
Felis catus CCAR2 VGNC VGNC:60443